Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159625688> ?p ?o ?g. }
- W3159625688 endingPage "530" @default.
- W3159625688 startingPage "519" @default.
- W3159625688 abstract "Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. PC were present in all (100%) of the pleomorphic adenomas (PAs), basal cell adenomas (BCAs), adenoid cystic carcinomas (AdCCs), and basal cell adenocarcinomas (BCAcs) examined, but absent in all (0%) of the Warthin tumours, salivary duct carcinomas, mucoepidermoid carcinomas, and acinic cell carcinomas examined. PC were also detected by electron-microscopic analysis using the NanoSuit method. It is worthy of note that the former category and latter category of tumours contained and did not contain a basaloid/myoepithelial differentiation component, respectively. The four types of PC-positive SGTs showed longer PC than normal and exhibited a characteristic distribution pattern of the PC in the ductal and basaloid/neoplastic myoepithelial components. Two PC-positive carcinomas (AdCC and BCAc) still possessed PC in their recurrent/metastatic sites. Interestingly, activation of the Hedgehog signalling pathway, shown by predominantly nuclear GLI1 expression, was significantly more frequently observed in PC-positive SGTs. Finally, we identified tau tubulin kinase 2 (TTBK2) as being possibly involved in the production of PC in SGTs. Taken together, our findings indicate that SGTs that exhibit basaloid/myoepithelial differentiation (PA, BCA, AdCC, and BCAc) are ciliated, and their PC exhibit tumour-specific characteristics, are involved in activation of the Hedgehog pathway, and are associated with TTBK2 upregulation, providing a significant and important link between SGT tumourigenesis and PC. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W3159625688 created "2021-05-10" @default.
- W3159625688 creator A5000601994 @default.
- W3159625688 creator A5017557720 @default.
- W3159625688 creator A5021451590 @default.
- W3159625688 creator A5027967276 @default.
- W3159625688 creator A5032598140 @default.
- W3159625688 creator A5044097329 @default.
- W3159625688 creator A5073008503 @default.
- W3159625688 creator A5073137752 @default.
- W3159625688 creator A5073574588 @default.
- W3159625688 creator A5080915116 @default.
- W3159625688 creator A5089153788 @default.
- W3159625688 date "2021-05-29" @default.
- W3159625688 modified "2023-10-16" @default.
- W3159625688 title "Identification and characterization of primary cilia‐positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation" @default.
- W3159625688 cites W1543890504 @default.
- W3159625688 cites W1966752179 @default.
- W3159625688 cites W1970915933 @default.
- W3159625688 cites W1971642804 @default.
- W3159625688 cites W1982833361 @default.
- W3159625688 cites W1982845946 @default.
- W3159625688 cites W1993416164 @default.
- W3159625688 cites W1995574906 @default.
- W3159625688 cites W1996628115 @default.
- W3159625688 cites W2032792789 @default.
- W3159625688 cites W2046199803 @default.
- W3159625688 cites W2055884152 @default.
- W3159625688 cites W2066480724 @default.
- W3159625688 cites W2070761767 @default.
- W3159625688 cites W2075026349 @default.
- W3159625688 cites W2100416170 @default.
- W3159625688 cites W2107394975 @default.
- W3159625688 cites W2114819889 @default.
- W3159625688 cites W2122114473 @default.
- W3159625688 cites W2140899176 @default.
- W3159625688 cites W2141640690 @default.
- W3159625688 cites W2145278939 @default.
- W3159625688 cites W2146325470 @default.
- W3159625688 cites W2153635433 @default.
- W3159625688 cites W2156531210 @default.
- W3159625688 cites W2300600264 @default.
- W3159625688 cites W2516679593 @default.
- W3159625688 cites W2549998959 @default.
- W3159625688 cites W2551346241 @default.
- W3159625688 cites W2554199252 @default.
- W3159625688 cites W2593682539 @default.
- W3159625688 cites W2620374753 @default.
- W3159625688 cites W2734540391 @default.
- W3159625688 cites W2785279167 @default.
- W3159625688 cites W2789417502 @default.
- W3159625688 cites W2896746371 @default.
- W3159625688 cites W2898200323 @default.
- W3159625688 cites W2901588773 @default.
- W3159625688 cites W2904013141 @default.
- W3159625688 cites W2904304803 @default.
- W3159625688 cites W2912975418 @default.
- W3159625688 cites W2934377443 @default.
- W3159625688 cites W2938245193 @default.
- W3159625688 cites W2949971983 @default.
- W3159625688 cites W2955683352 @default.
- W3159625688 cites W2971258452 @default.
- W3159625688 cites W2971331470 @default.
- W3159625688 cites W2995988256 @default.
- W3159625688 cites W3010310618 @default.
- W3159625688 cites W3084734383 @default.
- W3159625688 doi "https://doi.org/10.1002/path.5688" @default.
- W3159625688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33931860" @default.
- W3159625688 hasPublicationYear "2021" @default.
- W3159625688 type Work @default.
- W3159625688 sameAs 3159625688 @default.
- W3159625688 citedByCount "8" @default.
- W3159625688 countsByYear W31596256882021 @default.
- W3159625688 countsByYear W31596256882022 @default.
- W3159625688 countsByYear W31596256882023 @default.
- W3159625688 crossrefType "journal-article" @default.
- W3159625688 hasAuthorship W3159625688A5000601994 @default.
- W3159625688 hasAuthorship W3159625688A5017557720 @default.
- W3159625688 hasAuthorship W3159625688A5021451590 @default.
- W3159625688 hasAuthorship W3159625688A5027967276 @default.
- W3159625688 hasAuthorship W3159625688A5032598140 @default.
- W3159625688 hasAuthorship W3159625688A5044097329 @default.
- W3159625688 hasAuthorship W3159625688A5073008503 @default.
- W3159625688 hasAuthorship W3159625688A5073137752 @default.
- W3159625688 hasAuthorship W3159625688A5073574588 @default.
- W3159625688 hasAuthorship W3159625688A5080915116 @default.
- W3159625688 hasAuthorship W3159625688A5089153788 @default.
- W3159625688 hasConcept C104317684 @default.
- W3159625688 hasConcept C140884156 @default.
- W3159625688 hasConcept C142724271 @default.
- W3159625688 hasConcept C148738053 @default.
- W3159625688 hasConcept C204232928 @default.
- W3159625688 hasConcept C2778148616 @default.
- W3159625688 hasConcept C2778539099 @default.
- W3159625688 hasConcept C2778937882 @default.
- W3159625688 hasConcept C2780859518 @default.
- W3159625688 hasConcept C2781437628 @default.
- W3159625688 hasConcept C2908838615 @default.