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- W3159677655 endingPage "2877.e22" @default.
- W3159677655 startingPage "2860" @default.
- W3159677655 abstract "Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their nucleoli at the pronuclear interface are thought to be more likely to develop into healthy euploid embryos. Here, we show that the parental genomes cluster with nucleoli in each pronucleus within human and bovine zygotes, and clustering is required for the reliable unification of the parental genomes after fertilization. During migration of intact pronuclei, the parental genomes polarize toward each other in a process driven by centrosomes, dynein, microtubules, and nuclear pore complexes. The maternal and paternal chromosomes eventually cluster at the pronuclear interface, in direct proximity to each other, yet separated. Parental genome clustering ensures the rapid unification of the parental genomes on nuclear envelope breakdown. However, clustering often fails, leading to chromosome segregation errors and micronuclei, incompatible with healthy embryo development." @default.
- W3159677655 created "2021-05-10" @default.
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- W3159677655 date "2021-05-01" @default.
- W3159677655 modified "2023-10-14" @default.
- W3159677655 title "Parental genome unification is highly error-prone in mammalian embryos" @default.
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