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• W3159679933 endingPage "1636" @default.
• W3159679933 startingPage "1623" @default.
• W3159679933 abstract "Advances in neuromyelitis optica spectrum disorder pathogenesis have allowed the development of targeted drugs. These treatments act on core elements of the disease, including the pro-inflammatory IL-6 pathway (tocilizumab and satralizumab), B cells (rituximab and inebilizumab), and complement (eculizumab). According to recent phase II–III trials, biologics significantly reduced the risk of relapses in aquaporin-4-seropositive patients, whereas results were less striking in the small cohorts of aquaporin-4-seronegative patients. Most adverse events were mild to moderate, with systemic symptoms (headache, arthralgia) or infections (upper respiratory and urinary tracts) being most commonly reported." @default.
• W3159679933 created "2021-05-10" @default.
• W3159679933 creator A5003010065 @default.
• W3159679933 creator A5029999073 @default.
• W3159679933 creator A5032331162 @default.
• W3159679933 creator A5069531403 @default.
• W3159679933 date "2021-04-28" @default.
• W3159679933 modified "2023-09-23" @default.
• W3159679933 title "Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics" @default.
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