Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159684865> ?p ?o ?g. }
- W3159684865 endingPage "442" @default.
- W3159684865 startingPage "442" @default.
- W3159684865 abstract "Combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads, antibody-drug conjugates (ADCs) have emerged in recent years as an efficient therapeutic approach for the treatment of various cancers. Besides a number of approved drugs already on the market, there is a formidable follow-up of ADC candidates in clinical development. While selection of the appropriate antibody (A) and drug payload (D) is dictated by the pharmacology of the targeted disease, one has a broader choice of the conjugating linker (C). In the present paper, we review the chemistry of ADCs with a particular emphasis on the medicinal chemistry perspective, focusing on the chemical methods that enable the efficient assembly of the ADC from its three components and the controlled release of the drug payload." @default.
- W3159684865 created "2021-05-10" @default.
- W3159684865 creator A5025409839 @default.
- W3159684865 creator A5029798223 @default.
- W3159684865 creator A5038039905 @default.
- W3159684865 creator A5079274761 @default.
- W3159684865 date "2021-05-07" @default.
- W3159684865 modified "2023-10-09" @default.
- W3159684865 title "The Chemistry Behind ADCs" @default.
- W3159684865 cites W1263616324 @default.
- W3159684865 cites W1524815067 @default.
- W3159684865 cites W1555361166 @default.
- W3159684865 cites W1670498114 @default.
- W3159684865 cites W1905077449 @default.
- W3159684865 cites W1965931924 @default.
- W3159684865 cites W1966390946 @default.
- W3159684865 cites W1972189514 @default.
- W3159684865 cites W1974375788 @default.
- W3159684865 cites W1979230226 @default.
- W3159684865 cites W1979415145 @default.
- W3159684865 cites W1992175481 @default.
- W3159684865 cites W1992376269 @default.
- W3159684865 cites W1993966288 @default.
- W3159684865 cites W1994935137 @default.
- W3159684865 cites W1995431674 @default.
- W3159684865 cites W1995839837 @default.
- W3159684865 cites W1997537633 @default.
- W3159684865 cites W1998210183 @default.
- W3159684865 cites W1999416521 @default.
- W3159684865 cites W2000568282 @default.
- W3159684865 cites W2005684277 @default.
- W3159684865 cites W2008652440 @default.
- W3159684865 cites W2010363872 @default.
- W3159684865 cites W2010442254 @default.
- W3159684865 cites W2021099471 @default.
- W3159684865 cites W2021273725 @default.
- W3159684865 cites W2023546757 @default.
- W3159684865 cites W2024023279 @default.
- W3159684865 cites W2024520647 @default.
- W3159684865 cites W2031831504 @default.
- W3159684865 cites W2038002999 @default.
- W3159684865 cites W2039921716 @default.
- W3159684865 cites W2053800409 @default.
- W3159684865 cites W2055991021 @default.
- W3159684865 cites W2057316268 @default.
- W3159684865 cites W2065455501 @default.
- W3159684865 cites W2073087279 @default.
- W3159684865 cites W2073429992 @default.
- W3159684865 cites W2075071285 @default.
- W3159684865 cites W2076131977 @default.
- W3159684865 cites W2077248326 @default.
- W3159684865 cites W2079154601 @default.
- W3159684865 cites W2086353181 @default.
- W3159684865 cites W2086878176 @default.
- W3159684865 cites W2088964247 @default.
- W3159684865 cites W2090057677 @default.
- W3159684865 cites W2103498669 @default.
- W3159684865 cites W2104933395 @default.
- W3159684865 cites W2116150122 @default.
- W3159684865 cites W2123201918 @default.
- W3159684865 cites W2139761471 @default.
- W3159684865 cites W2145493440 @default.
- W3159684865 cites W2148127139 @default.
- W3159684865 cites W2148558870 @default.
- W3159684865 cites W2153699864 @default.
- W3159684865 cites W2163235231 @default.
- W3159684865 cites W2170257687 @default.
- W3159684865 cites W2171368669 @default.
- W3159684865 cites W2203423087 @default.
- W3159684865 cites W2225535431 @default.
- W3159684865 cites W2290649187 @default.
- W3159684865 cites W2292831572 @default.
- W3159684865 cites W2299463172 @default.
- W3159684865 cites W2307272104 @default.
- W3159684865 cites W2314772071 @default.
- W3159684865 cites W2323666809 @default.
- W3159684865 cites W2327088034 @default.
- W3159684865 cites W2387397851 @default.
- W3159684865 cites W2405513271 @default.
- W3159684865 cites W2419639370 @default.
- W3159684865 cites W2464202230 @default.
- W3159684865 cites W2465697235 @default.
- W3159684865 cites W2481540272 @default.
- W3159684865 cites W2493415560 @default.
- W3159684865 cites W2533801509 @default.
- W3159684865 cites W2549780925 @default.
- W3159684865 cites W2582255747 @default.
- W3159684865 cites W2593197196 @default.
- W3159684865 cites W2594015009 @default.
- W3159684865 cites W2595120106 @default.
- W3159684865 cites W2607719113 @default.
- W3159684865 cites W2612068032 @default.
- W3159684865 cites W2634968827 @default.
- W3159684865 cites W2732511611 @default.
- W3159684865 cites W2743893901 @default.
- W3159684865 cites W2746257012 @default.
- W3159684865 cites W2750012732 @default.
- W3159684865 cites W2767488985 @default.