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- W3159721848 endingPage "2002227" @default.
- W3159721848 startingPage "2002227" @default.
- W3159721848 abstract "The role of hydrogel properties in regulating the phenotype of triple negative metastatic breast cancer is investigated using four cell lines: the MDA-MB-231 parental line and three organotropic sublines BoM-1833 (bone-tropic), LM2-4175 (lung-tropic), and BrM2a-831 (brain-tropic). Each line is encapsulated and cultured for 15 days in three poly(ethylene glycol) (PEG)-based hydrogel formulations composed of proteolytically degradable PEG, integrin-ligating RGDS, and the non-degradable crosslinker N-vinyl pyrrolidone. Dormancy-associated metrics including viable cell density, proliferation, metabolism, apoptosis, chemoresistance, phosphorylated-ERK and -p38, and morphological characteristics are quantified. A multimetric classification approach is implemented to categorize each hydrogel-induced phenotype as: 1) growth, 2) balanced tumor dormancy, 3) balanced cellular dormancy, or 4) restricted survival, cellular dormancy. Hydrogels with high adhesivity and degradability promote growth. Hydrogels with no adhesivity, but high degradability, induce restricted survival, cellular dormancy in the parental line and balanced cellular dormancy in the organotropic lines. Hydrogels with reduced adhesivity and degradability induce balanced cellular dormancy in the parental and lung-tropic lines and balanced tumor mass dormancy in bone- and brain-tropic lines. The ability to induce escape from dormancy via dynamic incorporation of RGDS is also presented. These results demonstrate that ECM properties and organ-tropism synergistically regulate cancer cell phenotype and dormancy." @default.
- W3159721848 created "2021-05-10" @default.
- W3159721848 creator A5029729155 @default.
- W3159721848 creator A5071221768 @default.
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- W3159721848 date "2021-04-30" @default.
- W3159721848 modified "2023-09-29" @default.
- W3159721848 title "The Influence of Ligand Density and Degradability on Hydrogel Induced Breast Cancer Dormancy and Reactivation" @default.
- W3159721848 cites W1495945591 @default.
- W3159721848 cites W1585581387 @default.
- W3159721848 cites W1862989971 @default.
- W3159721848 cites W1971481045 @default.
- W3159721848 cites W1974335003 @default.
- W3159721848 cites W1980299983 @default.
- W3159721848 cites W1986471913 @default.
- W3159721848 cites W1990956934 @default.
- W3159721848 cites W1993497779 @default.
- W3159721848 cites W1995075648 @default.
- W3159721848 cites W2004682512 @default.
- W3159721848 cites W2007897263 @default.
- W3159721848 cites W2017746705 @default.
- W3159721848 cites W2028672331 @default.
- W3159721848 cites W2043166238 @default.
- W3159721848 cites W2044702943 @default.
- W3159721848 cites W2057151160 @default.
- W3159721848 cites W2060420126 @default.
- W3159721848 cites W2062265555 @default.
- W3159721848 cites W2067897176 @default.
- W3159721848 cites W2076679216 @default.
- W3159721848 cites W2080183018 @default.
- W3159721848 cites W2080232352 @default.
- W3159721848 cites W2081721488 @default.
- W3159721848 cites W2082833890 @default.
- W3159721848 cites W2088035579 @default.
- W3159721848 cites W2089370460 @default.
- W3159721848 cites W2090399120 @default.
- W3159721848 cites W2106263242 @default.
- W3159721848 cites W2115436106 @default.
- W3159721848 cites W2119419588 @default.
- W3159721848 cites W2130202974 @default.
- W3159721848 cites W2132966617 @default.
- W3159721848 cites W2134557975 @default.
- W3159721848 cites W2150902592 @default.
- W3159721848 cites W2152678130 @default.
- W3159721848 cites W2167378116 @default.
- W3159721848 cites W2169855644 @default.
- W3159721848 cites W2171298396 @default.
- W3159721848 cites W2189311214 @default.
- W3159721848 cites W2263461267 @default.
- W3159721848 cites W2271721498 @default.
- W3159721848 cites W2490923018 @default.
- W3159721848 cites W2500320361 @default.
- W3159721848 cites W2524806147 @default.
- W3159721848 cites W2527723445 @default.
- W3159721848 cites W2581605534 @default.
- W3159721848 cites W2612653435 @default.
- W3159721848 cites W2622035685 @default.
- W3159721848 cites W2729738977 @default.
- W3159721848 cites W2781664750 @default.
- W3159721848 cites W2782691474 @default.
- W3159721848 cites W2789533631 @default.
- W3159721848 cites W2807221590 @default.
- W3159721848 cites W2884814314 @default.
- W3159721848 cites W2885845888 @default.
- W3159721848 cites W2891651490 @default.
- W3159721848 cites W2894117338 @default.
- W3159721848 cites W2898068044 @default.
- W3159721848 cites W2907979437 @default.
- W3159721848 cites W2910716398 @default.
- W3159721848 cites W2916356553 @default.
- W3159721848 cites W2942689039 @default.
- W3159721848 cites W2944159463 @default.
- W3159721848 cites W2950471142 @default.
- W3159721848 cites W2986614206 @default.
- W3159721848 cites W2995322453 @default.
- W3159721848 cites W2996295883 @default.
- W3159721848 cites W3003806434 @default.
- W3159721848 cites W3008956909 @default.
- W3159721848 cites W3009285779 @default.
- W3159721848 cites W3011961818 @default.
- W3159721848 cites W3015450697 @default.
- W3159721848 cites W3016522056 @default.
- W3159721848 cites W3019462331 @default.
- W3159721848 cites W3031826692 @default.
- W3159721848 cites W3036924294 @default.
- W3159721848 cites W3037787783 @default.
- W3159721848 cites W3038262479 @default.
- W3159721848 cites W3040396580 @default.
- W3159721848 cites W3047847475 @default.
- W3159721848 cites W3090731162 @default.
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- W3159721848 doi "https://doi.org/10.1002/adhm.202002227" @default.
- W3159721848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8555704" @default.
- W3159721848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33929776" @default.
- W3159721848 hasPublicationYear "2021" @default.
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