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- W3159736435 abstract "Abstract Breast cancer is a common malignancy that is highly lethal. Due to the poor prognosis, more effective and efficient treatment methods are urgently needed. Rutin (RUT) is a traditional Chinese medicine reported to have a variety of pharmacological properties, including anticancer properties. However, the effects of RUT on breast cancer and its underlying molecular mechanism of action remain unclear. In the present study, we observed a significant downregulation of microRNA (miR)−129‐1‐3p in mouse breast cancer cells (4T1) compared with the expression in mouse normal breast epithelial cells (HC11). We also found that RUT could increase the expression of miR‐129‐1‐3p in 4T1 cells and suppress cell proliferation. To elucidate the molecular mechanism of action of RUT, miR‐129‐1‐3p mimics and its inhibitor were transfected into 4T1 cells. miR‐129‐1‐3p overexpression could inhibit the proliferation, invasion, migration, and calcium overload of mouse breast cancer cells and also enhance apoptosis, whereas miR‐129‐1‐3p knockdown had the opposite effects. Taken together, cell‐based experiments indicated that RUT restrains the growth of mouse breast cancer cells by regulating the miR‐129‐1‐3p/Ca 2+ signaling pathway. This study also revealed the inhibitory effect of RUT on breast cancer cells at the noncoding RNA level and provided a theoretical foundation for the application of RUT as a drug to inhibit tumor growth." @default.
- W3159736435 created "2021-05-10" @default.
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- W3159736435 date "2021-04-29" @default.
- W3159736435 modified "2023-10-02" @default.
- W3159736435 title "Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA‐129‐1‐3p‐mediated calcium signaling pathway" @default.
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- W3159736435 doi "https://doi.org/10.1002/jbt.22794" @default.
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