FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159765955> ?p ?o ?g. }

• W3159765955 endingPage "2547" @default.
• W3159765955 startingPage "2547" @default.
• W3159765955 abstract "Patients with hematologic malignancies require intensive therapies, including high-dose chemotherapy. Antimetabolite–methotrexate (MTX) has been used for many years in the treatment of leukemia and in lymphoma patients. However, the lack of MTX specificity causes a significant risk of morbidity, mortality, and severe side effects that impairs the quality of patients’ life. Therefore, novel targeted therapies based on the malignant cells’ common traits have become an essential treatment strategy. Glucose transporters have been found to be overexpressed in neoplastic cells, including hematologic malignancies. In this study, we biologically evaluated a novel glucose–methotrexate conjugate (Glu–MTX) in comparison to a free MTX. The research aimed to assess the effectiveness of Glu–MTX on chosen human lymphoma and leukemia cell lines. Cell cytotoxicity was verified by MTT viability test and flow cytometry. Moreover, the cell cycle and cellular uptake of Glu–MTX were evaluated. Our study reveals that conjugation of methotrexate with glucose significantly increases drug uptake and results in similar cytotoxicity of the synthesized compound. Although the finding has been confined to in vitro studies, our observations shed light on a potential therapeutic approach that increases the selectivity of chemotherapeutics and can improve leukemia and lymphoma patients’ outcomes." @default.
• W3159765955 created "2021-05-10" @default.
• W3159765955 creator A5001059339 @default.
• W3159765955 creator A5010960730 @default.
• W3159765955 creator A5019277451 @default.
• W3159765955 creator A5021583161 @default.
• W3159765955 creator A5036314996 @default.
• W3159765955 creator A5042402358 @default.
• W3159765955 creator A5059415729 @default.
• W3159765955 creator A5084147491 @default.
• W3159765955 date "2021-04-27" @default.
• W3159765955 modified "2023-10-01" @default.
• W3159765955 title "The Effect of a New Glucose–Methotrexate Conjugate on Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Cell Lines" @default.
• W3159765955 cites W1968963363 @default.
• W3159765955 cites W1981019211 @default.
• W3159765955 cites W2018107585 @default.
• W3159765955 cites W2026411130 @default.
• W3159765955 cites W2056650132 @default.
• W3159765955 cites W2077605453 @default.
• W3159765955 cites W2097259163 @default.
• W3159765955 cites W2162586071 @default.
• W3159765955 cites W2223344044 @default.
• W3159765955 cites W2606476040 @default.
• W3159765955 cites W2704695716 @default.
• W3159765955 cites W2761079385 @default.
• W3159765955 cites W2807291844 @default.
• W3159765955 cites W2808391024 @default.
• W3159765955 cites W2946651253 @default.
• W3159765955 cites W2948672499 @default.
• W3159765955 cites W3000120095 @default.
• W3159765955 cites W3024378081 @default.
• W3159765955 cites W3095221736 @default.
• W3159765955 cites W3099180033 @default.
• W3159765955 cites W3127110395 @default.
• W3159765955 cites W744713846 @default.
• W3159765955 doi "https://doi.org/10.3390/molecules26092547" @default.
• W3159765955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8123764" @default.
• W3159765955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33925555" @default.
• W3159765955 hasPublicationYear "2021" @default.
• W3159765955 type Work @default.
• W3159765955 sameAs 3159765955 @default.
• W3159765955 citedByCount "2" @default.
• W3159765955 countsByYear W31597659552023 @default.
• W3159765955 crossrefType "journal-article" @default.
• W3159765955 hasAuthorship W3159765955A5001059339 @default.
• W3159765955 hasAuthorship W3159765955A5010960730 @default.
• W3159765955 hasAuthorship W3159765955A5019277451 @default.
• W3159765955 hasAuthorship W3159765955A5021583161 @default.
• W3159765955 hasAuthorship W3159765955A5036314996 @default.
• W3159765955 hasAuthorship W3159765955A5042402358 @default.
• W3159765955 hasAuthorship W3159765955A5059415729 @default.
• W3159765955 hasAuthorship W3159765955A5084147491 @default.
• W3159765955 hasBestOaLocation W31597659551 @default.
• W3159765955 hasConcept C109316439 @default.
• W3159765955 hasConcept C126322002 @default.
• W3159765955 hasConcept C134306372 @default.
• W3159765955 hasConcept C143998085 @default.
• W3159765955 hasConcept C197336794 @default.
• W3159765955 hasConcept C202751555 @default.
• W3159765955 hasConcept C203014093 @default.
• W3159765955 hasConcept C2776090121 @default.
• W3159765955 hasConcept C2776694085 @default.
• W3159765955 hasConcept C2777478502 @default.
• W3159765955 hasConcept C2778397455 @default.
• W3159765955 hasConcept C2778461978 @default.
• W3159765955 hasConcept C2779338263 @default.
• W3159765955 hasConcept C2781059491 @default.
• W3159765955 hasConcept C2781382166 @default.
• W3159765955 hasConcept C33923547 @default.
• W3159765955 hasConcept C502942594 @default.
• W3159765955 hasConcept C55493867 @default.
• W3159765955 hasConcept C71924100 @default.
• W3159765955 hasConcept C86803240 @default.
• W3159765955 hasConcept C8891405 @default.
• W3159765955 hasConcept C98274493 @default.
• W3159765955 hasConceptScore W3159765955C109316439 @default.
• W3159765955 hasConceptScore W3159765955C126322002 @default.
• W3159765955 hasConceptScore W3159765955C134306372 @default.
• W3159765955 hasConceptScore W3159765955C143998085 @default.
• W3159765955 hasConceptScore W3159765955C197336794 @default.
• W3159765955 hasConceptScore W3159765955C202751555 @default.
• W3159765955 hasConceptScore W3159765955C203014093 @default.
• W3159765955 hasConceptScore W3159765955C2776090121 @default.
• W3159765955 hasConceptScore W3159765955C2776694085 @default.
• W3159765955 hasConceptScore W3159765955C2777478502 @default.
• W3159765955 hasConceptScore W3159765955C2778397455 @default.
• W3159765955 hasConceptScore W3159765955C2778461978 @default.
• W3159765955 hasConceptScore W3159765955C2779338263 @default.
• W3159765955 hasConceptScore W3159765955C2781059491 @default.
• W3159765955 hasConceptScore W3159765955C2781382166 @default.
• W3159765955 hasConceptScore W3159765955C33923547 @default.
• W3159765955 hasConceptScore W3159765955C502942594 @default.
• W3159765955 hasConceptScore W3159765955C55493867 @default.
• W3159765955 hasConceptScore W3159765955C71924100 @default.
• W3159765955 hasConceptScore W3159765955C86803240 @default.
• W3159765955 hasConceptScore W3159765955C8891405 @default.
• W3159765955 hasConceptScore W3159765955C98274493 @default.
• W3159765955 hasFunder F4320325938 @default.

• next