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• W3159768014 abstract "Nuclear receptors (NRs) are a family of transcription factors that are regulated endogenously by small lipophilic ligands. Recently, liquid-liquid phase separation (LLPS) has appeared as a new aspect of NR function. In the human retinoid X receptor γ (hRXRγ), the inherently disordered AB region undergoes LLPS via homotypic multivalent interactions. To better understand the functions of liquid condensates, a clear view of the molecular interactions underlying the LLPS are required. The phase separation propensity of the AB region of hRXRγ (AB_hRXG) at a high NaCl concentration, a lower critical solution temperature behavior, and also sensitivity to kosmotropic salts and 1,6-hexanediol, which all indicate the importance of hydrophobic interactions in the formation of AB_hRXG liquid condensates, is presented in the paper. Additionally, molecular crowding agents and TMAO shift the equilibrium, in turn enabling phase transition at lower AB_hRXG concentrations. Although the LLPS of the proteins can lead to aggregation, AB_hRXG liquid condensates are not aggregation prone. Interestingly, the formation of AB_hRXG liquid condensates has an impact on the rest of the receptor, as AB_hRXG liquid condensates recruit the remaining fragment of hRXRγ into the droplets. The ability of AB_hRXG to undergo LLPS might be important for gene expression regulation." @default.
• W3159768014 created "2021-05-10" @default.
• W3159768014 creator A5065871816 @default.
• W3159768014 creator A5078125259 @default.
• W3159768014 creator A5079271200 @default.
• W3159768014 date "2021-07-01" @default.
• W3159768014 modified "2023-10-01" @default.
• W3159768014 title "Liquid-liquid phase separation of the intrinsically disordered AB region of hRXRγ is driven by hydrophobic interactions" @default.
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• W3159768014 doi "https://doi.org/10.1016/j.ijbiomac.2021.05.035" @default.
• W3159768014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33971237" @default.
• W3159768014 hasPublicationYear "2021" @default.
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