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- W3159796955 abstract "Abstract Amongst the numerous genes associated with intellectual disability, SYNGAP1 stands out for its frequency and penetrance of loss-of-function variants found in patients, as well as the wide range of co-morbid disorders associated with its mutation. Most studies exploring the pathophysiological alterations caused by Syngap1 haploinsufficiency in mouse models have focused on cognitive problems and epilepsy, however whether and to what extent sensory perception and processing are altered by Syngap1 haploinsufficiency is less clear. By performing EEG recordings in awake mice, we identified specific alterations in multiple aspects of auditory and visual processing, including increased baseline gamma oscillation power, increased theta/gamma phase amplitude coupling following stimulus presentation and abnormal neural entrainment in response to different sensory modality-specific frequencies. We also report lack of habituation to repetitive auditory stimuli and abnormal deviant sound detection. Interestingly, we found that most of these alterations are present in human patients as well, thus making them strong candidates as translational biomarkers of sensory-processing alterations associated with SYNGAP1/Syngap1 haploinsufficiency." @default.
- W3159796955 created "2021-05-10" @default.
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- W3159796955 date "2021-04-29" @default.
- W3159796955 modified "2023-10-17" @default.
- W3159796955 title "Sensory processing dysregulations as reliable translational biomarkers in <i>SYNGAP1</i> haploinsufficiency" @default.
- W3159796955 cites W1129581376 @default.
- W3159796955 cites W1544607115 @default.
- W3159796955 cites W1921449796 @default.
- W3159796955 cites W1978389345 @default.
- W3159796955 cites W1987095365 @default.
- W3159796955 cites W1989666886 @default.
- W3159796955 cites W1989879415 @default.
- W3159796955 cites W2001896608 @default.
- W3159796955 cites W2005847560 @default.
- W3159796955 cites W2006079595 @default.
- W3159796955 cites W2033509631 @default.
- W3159796955 cites W2033669724 @default.
- W3159796955 cites W2033759150 @default.
- W3159796955 cites W2067058552 @default.
- W3159796955 cites W2077548264 @default.
- W3159796955 cites W2082905404 @default.
- W3159796955 cites W2087216143 @default.
- W3159796955 cites W2087622664 @default.
- W3159796955 cites W2090643466 @default.
- W3159796955 cites W2090717981 @default.
- W3159796955 cites W2093196811 @default.
- W3159796955 cites W2101644199 @default.
- W3159796955 cites W2104049715 @default.
- W3159796955 cites W2105350975 @default.
- W3159796955 cites W2109256677 @default.
- W3159796955 cites W2114350859 @default.
- W3159796955 cites W2115810652 @default.
- W3159796955 cites W2120768649 @default.
- W3159796955 cites W2128495200 @default.
- W3159796955 cites W2132278635 @default.
- W3159796955 cites W2149561999 @default.
- W3159796955 cites W2152511855 @default.
- W3159796955 cites W2159814214 @default.
- W3159796955 cites W2162013747 @default.
- W3159796955 cites W2163119252 @default.
- W3159796955 cites W2165730296 @default.
- W3159796955 cites W2166073443 @default.
- W3159796955 cites W2170397258 @default.
- W3159796955 cites W2171668474 @default.
- W3159796955 cites W2177522049 @default.
- W3159796955 cites W2190199438 @default.
- W3159796955 cites W2197716869 @default.
- W3159796955 cites W2288238997 @default.
- W3159796955 cites W2330883635 @default.
- W3159796955 cites W2336680935 @default.
- W3159796955 cites W2338176068 @default.
- W3159796955 cites W2343346357 @default.
- W3159796955 cites W2396439512 @default.
- W3159796955 cites W2413631243 @default.
- W3159796955 cites W2461298255 @default.
- W3159796955 cites W2528781707 @default.
- W3159796955 cites W2531263448 @default.
- W3159796955 cites W2553225945 @default.
- W3159796955 cites W2581649032 @default.
- W3159796955 cites W2596913176 @default.
- W3159796955 cites W2613476512 @default.
- W3159796955 cites W2621535055 @default.
- W3159796955 cites W2725689694 @default.
- W3159796955 cites W2735621804 @default.
- W3159796955 cites W2754885897 @default.
- W3159796955 cites W2756126749 @default.
- W3159796955 cites W2758053316 @default.
- W3159796955 cites W2768807341 @default.
- W3159796955 cites W2778754068 @default.
- W3159796955 cites W2790710383 @default.
- W3159796955 cites W2793466044 @default.
- W3159796955 cites W2794978048 @default.
- W3159796955 cites W2892897550 @default.
- W3159796955 cites W2904696555 @default.
- W3159796955 cites W2941342380 @default.
- W3159796955 cites W2944145362 @default.
- W3159796955 cites W2966987820 @default.
- W3159796955 cites W2969566072 @default.
- W3159796955 cites W2972335424 @default.
- W3159796955 cites W2980177172 @default.
- W3159796955 cites W2998765876 @default.
- W3159796955 cites W3007964422 @default.
- W3159796955 cites W3038681662 @default.
- W3159796955 cites W3080966968 @default.
- W3159796955 cites W3100165853 @default.
- W3159796955 cites W3127291680 @default.
- W3159796955 cites W4248139563 @default.
- W3159796955 doi "https://doi.org/10.1101/2021.04.28.441866" @default.
- W3159796955 hasPublicationYear "2021" @default.
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