FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159839169> ?p ?o ?g. }

• W3159839169 abstract "Abstract An evaluation of the APPswe/PS1dE9 transgenic AD mouse, presenting with the toxic Aβ1-42 deposition found in human AD, allowed us to characterize time-dependent changes in inflammatory and cholinergic markers present in AD. Astrogliosis was observed in cortex and hippocampus, with cellular loss occurring in the same areas in which Aβ plaques were present. In this setting, we found early significantly elevated levels of IL-1β and TNFα gene expression; with the hippocampus showing the highest IL-1β expression. To investigate the cholinergic anti-inflammatory pathway, the expression of nicotinic receptors (nAChRs) and cholinesterase enzymes also was evaluated. The anti-inflammatory nAChRα7, α4, and β2 were particularly increased at 6 months of age in the hippocampus, potentially as a strategy to counteract Aβ deposition and the ensuing inflammatory state. A time-dependent subunit switch to the α3β4 type occurred. Whether α3, β4 subunits have a pro-inflammatory or an inhibitory effect on ACh stimulation remains speculative. Aβ1-42 deposition, neuronal loss and increased astrocytes were detected, and a time-dependent change in components of the cholinergic anti-inflammatory pathway were observed. A greater understanding of time-dependent Aβ/nAChRs interactions may aid in defining new therapeutic strategies and novel molecular targets." @default.
• W3159839169 created "2021-05-10" @default.
• W3159839169 creator A5027259290 @default.
• W3159839169 creator A5034168009 @default.
• W3159839169 creator A5037842162 @default.
• W3159839169 creator A5038929286 @default.
• W3159839169 creator A5053476405 @default.
• W3159839169 creator A5056649584 @default.
• W3159839169 creator A5083012734 @default.
• W3159839169 date "2021-05-06" @default.
• W3159839169 modified "2023-09-23" @default.
• W3159839169 title "nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse" @default.
• W3159839169 cites W1149434589 @default.
• W3159839169 cites W1430758748 @default.
• W3159839169 cites W1494195172 @default.
• W3159839169 cites W1537745645 @default.
• W3159839169 cites W1587164985 @default.
• W3159839169 cites W1598962518 @default.
• W3159839169 cites W1612456855 @default.
• W3159839169 cites W1841850981 @default.
• W3159839169 cites W1903705656 @default.
• W3159839169 cites W1975141413 @default.
• W3159839169 cites W1979480311 @default.
• W3159839169 cites W1982706802 @default.
• W3159839169 cites W1982932429 @default.
• W3159839169 cites W1983166842 @default.
• W3159839169 cites W1986529601 @default.
• W3159839169 cites W1989964812 @default.
• W3159839169 cites W1991435932 @default.
• W3159839169 cites W1994067502 @default.
• W3159839169 cites W2004739315 @default.
• W3159839169 cites W2007143131 @default.
• W3159839169 cites W2009725468 @default.
• W3159839169 cites W2016148530 @default.
• W3159839169 cites W2027131229 @default.
• W3159839169 cites W2030223062 @default.
• W3159839169 cites W2033154101 @default.
• W3159839169 cites W2039402692 @default.
• W3159839169 cites W2043163613 @default.
• W3159839169 cites W2050668497 @default.
• W3159839169 cites W2054366648 @default.
• W3159839169 cites W2061164005 @default.
• W3159839169 cites W2062705501 @default.
• W3159839169 cites W2068225545 @default.
• W3159839169 cites W2069368135 @default.
• W3159839169 cites W2070264071 @default.
• W3159839169 cites W2070484780 @default.
• W3159839169 cites W2076749095 @default.
• W3159839169 cites W2080946103 @default.
• W3159839169 cites W2082152407 @default.
• W3159839169 cites W2084972185 @default.
• W3159839169 cites W2087243986 @default.
• W3159839169 cites W2089963291 @default.
• W3159839169 cites W2091102323 @default.
• W3159839169 cites W2095536623 @default.
• W3159839169 cites W2097391583 @default.
• W3159839169 cites W2100899787 @default.
• W3159839169 cites W2103440561 @default.
• W3159839169 cites W2104156437 @default.
• W3159839169 cites W2104838343 @default.
• W3159839169 cites W2108244474 @default.
• W3159839169 cites W2109779185 @default.
• W3159839169 cites W2111863354 @default.
• W3159839169 cites W2116488337 @default.
• W3159839169 cites W2116784956 @default.
• W3159839169 cites W2120003285 @default.
• W3159839169 cites W2126800086 @default.
• W3159839169 cites W2130009335 @default.
• W3159839169 cites W2134631162 @default.
• W3159839169 cites W2135490042 @default.
• W3159839169 cites W2161605623 @default.
• W3159839169 cites W2163048761 @default.
• W3159839169 cites W2185500845 @default.
• W3159839169 cites W2298946842 @default.
• W3159839169 cites W2326153453 @default.
• W3159839169 cites W2343501588 @default.
• W3159839169 cites W2427261560 @default.
• W3159839169 cites W2468810680 @default.
• W3159839169 cites W2479999044 @default.
• W3159839169 cites W2550283848 @default.
• W3159839169 cites W2558506950 @default.
• W3159839169 cites W257908771 @default.
• W3159839169 cites W2607980041 @default.
• W3159839169 cites W2613121599 @default.
• W3159839169 cites W2738888781 @default.
• W3159839169 cites W2753006146 @default.
• W3159839169 cites W2783200078 @default.
• W3159839169 cites W2787750161 @default.
• W3159839169 cites W2805257646 @default.
• W3159839169 cites W2910284224 @default.
• W3159839169 cites W2922895976 @default.
• W3159839169 cites W2964111426 @default.
• W3159839169 cites W2968595378 @default.
• W3159839169 cites W2989784968 @default.
• W3159839169 cites W3018541302 @default.
• W3159839169 cites W4241113024 @default.
• W3159839169 cites W962937402 @default.
• W3159839169 doi "https://doi.org/10.1038/s41598-021-89139-x" @default.
• W3159839169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8102527" @default.
• W3159839169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33958667" @default.

• next