FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159867898> ?p ?o ?g. }

• W3159867898 endingPage "1149" @default.
• W3159867898 startingPage "1148" @default.
• W3159867898 abstract "Acinetobacter baumannii has emerged as a challenging pathogen for many institutions globally. While its recognition as a multidrug-resistant organism is growing, there remains limited literature documenting the disease burden in patients with cystic fibrosis (CF).1 An analysis of isolates referred to by the Burkholderia cepacia Research Laboratory and Repository (University of Michigan) identified A. baumannii in specimens from only five US CF patients between 2004 and 2008.2 The analysis did not provide details on whether these were adult or paediatric patients, thus highlighting the paucity of literature describing the clinical course of A. baumannii isolation in CF patients. In light of the paucity of literature, we write to illustrate the clinical impact of A. baumannii infection in a paediatric patient with CF. The patient, who is heterozygous for G27X/2622 + 1G > A mutation, attended a routine clinic in June 2018 with weight loss, ppFEV1 below baseline and an increased Lung Clearance Index (LCI). A cough swab was positive for A. baumannii. Despite efforts to establish an appropriate eradication regime, there was mounting evidence that infection with A. baumannii was having a negative impact on our patient's clinical status, with a persistent cough and poor weight gain (Fig. 1). In addition, analysis of data from multiple breath washouts showed that there were variations in the LCI values at multiple time points (Fig. 1). LCI values are produced from multiple breath washouts detecting subtle changes in the small airways.3 Following a third, more prolonged eradication regime (ciprofloxacin (20 mg/kg per dose given twice daily orally) for 4 weeks and tobramycin for inhalation (300 mg nebulised twice daily) for 4 weeks), there was a resolution of the cough, an eradication of organism on swab and an improvement in measured clinical parameters (Fig. 1). It is therefore reasonable to assume that A. baumannii has an occult, pathogen-mediated, impact on the small airways resulting in clinical symptoms and reduced ventilation homogeneity in paediatric patients with CF. This clinical course suggests that when A. baumannii becomes established in the CF airway it can act as a pathogen, rather than coloniser, warranting aggressive treatment to eradicate. This information is of value to paediatric physicians caring for children with CF world-wide. Written informed consent was obtained from the patient's mother to publish this case." @default.
• W3159867898 created "2021-05-10" @default.
• W3159867898 creator A5004156344 @default.
• W3159867898 creator A5036075632 @default.
• W3159867898 creator A5037143692 @default.
• W3159867898 creator A5054345394 @default.
• W3159867898 creator A5054538584 @default.
• W3159867898 creator A5064879905 @default.
• W3159867898 creator A5078319056 @default.
• W3159867898 creator A5091495398 @default.
• W3159867898 date "2021-04-30" @default.
• W3159867898 modified "2023-09-26" @default.
• W3159867898 title "Acinetobacter baumannii Infection in a Child with Cystic Fibrosis" @default.
• W3159867898 cites W2116388403 @default.
• W3159867898 cites W2793361402 @default.
• W3159867898 doi "https://doi.org/10.1111/jpc.15536" @default.
• W3159867898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33929764" @default.
• W3159867898 hasPublicationYear "2021" @default.
• W3159867898 type Work @default.
• W3159867898 sameAs 3159867898 @default.
• W3159867898 citedByCount "0" @default.
• W3159867898 crossrefType "journal-article" @default.
• W3159867898 hasAuthorship W3159867898A5004156344 @default.
• W3159867898 hasAuthorship W3159867898A5036075632 @default.
• W3159867898 hasAuthorship W3159867898A5037143692 @default.
• W3159867898 hasAuthorship W3159867898A5054345394 @default.
• W3159867898 hasAuthorship W3159867898A5054538584 @default.
• W3159867898 hasAuthorship W3159867898A5064879905 @default.
• W3159867898 hasAuthorship W3159867898A5078319056 @default.
• W3159867898 hasAuthorship W3159867898A5091495398 @default.
• W3159867898 hasBestOaLocation W31598678981 @default.
• W3159867898 hasConcept C126322002 @default.
• W3159867898 hasConcept C177713679 @default.
• W3159867898 hasConcept C187212893 @default.
• W3159867898 hasConcept C2775941552 @default.
• W3159867898 hasConcept C2776315533 @default.
• W3159867898 hasConcept C2776938444 @default.
• W3159867898 hasConcept C2777637488 @default.
• W3159867898 hasConcept C2777756538 @default.
• W3159867898 hasConcept C2778512257 @default.
• W3159867898 hasConcept C2780855054 @default.
• W3159867898 hasConcept C501593827 @default.
• W3159867898 hasConcept C523546767 @default.
• W3159867898 hasConcept C54355233 @default.
• W3159867898 hasConcept C71924100 @default.
• W3159867898 hasConcept C86803240 @default.
• W3159867898 hasConcept C89423630 @default.
• W3159867898 hasConceptScore W3159867898C126322002 @default.
• W3159867898 hasConceptScore W3159867898C177713679 @default.
• W3159867898 hasConceptScore W3159867898C187212893 @default.
• W3159867898 hasConceptScore W3159867898C2775941552 @default.
• W3159867898 hasConceptScore W3159867898C2776315533 @default.
• W3159867898 hasConceptScore W3159867898C2776938444 @default.
• W3159867898 hasConceptScore W3159867898C2777637488 @default.
• W3159867898 hasConceptScore W3159867898C2777756538 @default.
• W3159867898 hasConceptScore W3159867898C2778512257 @default.
• W3159867898 hasConceptScore W3159867898C2780855054 @default.
• W3159867898 hasConceptScore W3159867898C501593827 @default.
• W3159867898 hasConceptScore W3159867898C523546767 @default.
• W3159867898 hasConceptScore W3159867898C54355233 @default.
• W3159867898 hasConceptScore W3159867898C71924100 @default.
• W3159867898 hasConceptScore W3159867898C86803240 @default.
• W3159867898 hasConceptScore W3159867898C89423630 @default.
• W3159867898 hasIssue "7" @default.
• W3159867898 hasLocation W31598678981 @default.
• W3159867898 hasOpenAccess W3159867898 @default.
• W3159867898 hasPrimaryLocation W31598678981 @default.
• W3159867898 hasRelatedWork W1924976901 @default.
• W3159867898 hasRelatedWork W2028927886 @default.
• W3159867898 hasRelatedWork W2041736386 @default.
• W3159867898 hasRelatedWork W2121259425 @default.
• W3159867898 hasRelatedWork W2150232178 @default.
• W3159867898 hasRelatedWork W2167865153 @default.
• W3159867898 hasRelatedWork W2169270251 @default.
• W3159867898 hasRelatedWork W2470343393 @default.
• W3159867898 hasRelatedWork W2891813746 @default.
• W3159867898 hasRelatedWork W778071727 @default.
• W3159867898 hasVolume "57" @default.
• W3159867898 isParatext "false" @default.
• W3159867898 isRetracted "false" @default.
• W3159867898 magId "3159867898" @default.
• W3159867898 workType "article" @default.