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- W3159895194 abstract "Abstract Background: Down syndrome (DS) is characterised by a series of immune dysregulations, of which interferon hyperreactivity is a key one as it is responsible for surging antiviral responses and probable initiation of an amplified cytokine storm. This biological condition is attributed to immune regulators encoded in chromosome 21. Moreover, DS is characterised by the coexistence of cardiovascular and respiratory anomalies as well as obesity, which constitutes a risk factor for SARS-CoV-2 respiratory disease (COVID-19). Case presentation: Of the total number of children 55 admitted to paediatric wards in Bergamo in the period between February to May 2020 for COVID-19 infection, we present 2 children with DS and confirmed COVID-19 diagnosis that had a severe course. In addition, both cases had one or more comorbidities, being cardiovascular anomalies, obesity, and/or OSA. Conclusions: Our observations indicate the need to consider children with DS a population at a risk of severe COVID-19." @default.
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- W3159895194 date "2020-07-17" @default.
- W3159895194 modified "2023-10-03" @default.
- W3159895194 title "COVID-19 and Children With Down Syndrome: is There Any Real Reason to Worry? Case Report" @default.
- W3159895194 doi "https://doi.org/10.21203/rs.3.rs-44432/v1" @default.
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