Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159898178> ?p ?o ?g. }
- W3159898178 endingPage "921" @default.
- W3159898178 startingPage "907" @default.
- W3159898178 abstract "Soil-transmitted helminths (Ascaris lumbricoides, hookworm and Trichuris trichiura) infect about one-fifth of the world’s population. The currently available drugs are all highly efficacious against A. lumbricoides. However, they are only moderately efficacious against hookworm and poorly efficacious against T. trichiura. Oxantel, a tetrahydropyrimidine derivative discovered in the 1970s, has recently been brought back to our attention given its high efficacy against T. trichiura infections (estimated 76% cure rate and 85% egg reduction rate at a 20 mg/kg dose). This review summarizes the current knowledge on oxantel pamoate and its use against T. trichiura infections in humans. Oxantel pamoate acts locally in the human gastrointestinal tract and binds to the parasite’s nicotinic acetylcholine receptor (nAChR), leading to a spastic paralysis of the worm and subsequent expulsion. The drug is metabolically stable, shows low permeability and low systemic bioavailability after oral use. Oxantel pamoate was found to be safe in humans, with only a few mild adverse events reported. Several clinical trials have investigated the efficacy of this drug against T. trichiura and suggest that oxantel pamoate is more efficacious against T. trichiura than the currently recommended drugs, which makes it a strong asset to the depleted drug armamentarium and could help delay or even prevent the development of resistance to existing drugs. We highlight existing data to support the use of oxantel pamoate against T. trichiura infections." @default.
- W3159898178 created "2021-05-10" @default.
- W3159898178 creator A5014625569 @default.
- W3159898178 creator A5029766219 @default.
- W3159898178 creator A5033452459 @default.
- W3159898178 creator A5049236901 @default.
- W3159898178 creator A5067632899 @default.
- W3159898178 creator A5067749952 @default.
- W3159898178 date "2021-04-30" @default.
- W3159898178 modified "2023-10-09" @default.
- W3159898178 title "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review" @default.
- W3159898178 cites W1813224642 @default.
- W3159898178 cites W1913615754 @default.
- W3159898178 cites W1976408061 @default.
- W3159898178 cites W1985868373 @default.
- W3159898178 cites W2000454376 @default.
- W3159898178 cites W20009588 @default.
- W3159898178 cites W2001794172 @default.
- W3159898178 cites W2007831078 @default.
- W3159898178 cites W2033854687 @default.
- W3159898178 cites W2042338901 @default.
- W3159898178 cites W2052975969 @default.
- W3159898178 cites W2057425825 @default.
- W3159898178 cites W2059351306 @default.
- W3159898178 cites W2063908191 @default.
- W3159898178 cites W2066004930 @default.
- W3159898178 cites W2076690407 @default.
- W3159898178 cites W2092119782 @default.
- W3159898178 cites W2100945467 @default.
- W3159898178 cites W2127255185 @default.
- W3159898178 cites W2130939565 @default.
- W3159898178 cites W2137613291 @default.
- W3159898178 cites W2155592985 @default.
- W3159898178 cites W2165954373 @default.
- W3159898178 cites W2496871551 @default.
- W3159898178 cites W2528950289 @default.
- W3159898178 cites W2567300897 @default.
- W3159898178 cites W2752945990 @default.
- W3159898178 cites W2759758131 @default.
- W3159898178 cites W2783160039 @default.
- W3159898178 cites W2800696010 @default.
- W3159898178 cites W2805482498 @default.
- W3159898178 cites W2891048222 @default.
- W3159898178 cites W2896007941 @default.
- W3159898178 cites W3028760640 @default.
- W3159898178 cites W3091095872 @default.
- W3159898178 cites W3119457757 @default.
- W3159898178 cites W41273265 @default.
- W3159898178 cites W4250306537 @default.
- W3159898178 doi "https://doi.org/10.1007/s40265-021-01505-1" @default.
- W3159898178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8144136" @default.
- W3159898178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33929716" @default.
- W3159898178 hasPublicationYear "2021" @default.
- W3159898178 type Work @default.
- W3159898178 sameAs 3159898178 @default.
- W3159898178 citedByCount "9" @default.
- W3159898178 countsByYear W31598981782021 @default.
- W3159898178 countsByYear W31598981782022 @default.
- W3159898178 countsByYear W31598981782023 @default.
- W3159898178 crossrefType "journal-article" @default.
- W3159898178 hasAuthorship W3159898178A5014625569 @default.
- W3159898178 hasAuthorship W3159898178A5029766219 @default.
- W3159898178 hasAuthorship W3159898178A5033452459 @default.
- W3159898178 hasAuthorship W3159898178A5049236901 @default.
- W3159898178 hasAuthorship W3159898178A5067632899 @default.
- W3159898178 hasAuthorship W3159898178A5067749952 @default.
- W3159898178 hasBestOaLocation W31598981781 @default.
- W3159898178 hasConcept C165901193 @default.
- W3159898178 hasConcept C203014093 @default.
- W3159898178 hasConcept C2776117458 @default.
- W3159898178 hasConcept C2777364306 @default.
- W3159898178 hasConcept C2780035454 @default.
- W3159898178 hasConcept C71924100 @default.
- W3159898178 hasConcept C98274493 @default.
- W3159898178 hasConceptScore W3159898178C165901193 @default.
- W3159898178 hasConceptScore W3159898178C203014093 @default.
- W3159898178 hasConceptScore W3159898178C2776117458 @default.
- W3159898178 hasConceptScore W3159898178C2777364306 @default.
- W3159898178 hasConceptScore W3159898178C2780035454 @default.
- W3159898178 hasConceptScore W3159898178C71924100 @default.
- W3159898178 hasConceptScore W3159898178C98274493 @default.
- W3159898178 hasFunder F4320310466 @default.
- W3159898178 hasFunder F4320332999 @default.
- W3159898178 hasIssue "8" @default.
- W3159898178 hasLocation W31598981781 @default.
- W3159898178 hasLocation W31598981782 @default.
- W3159898178 hasOpenAccess W3159898178 @default.
- W3159898178 hasPrimaryLocation W31598981781 @default.
- W3159898178 hasRelatedWork W2042278949 @default.
- W3159898178 hasRelatedWork W2051177080 @default.
- W3159898178 hasRelatedWork W2053938906 @default.
- W3159898178 hasRelatedWork W2196953754 @default.
- W3159898178 hasRelatedWork W2233466589 @default.
- W3159898178 hasRelatedWork W2301480749 @default.
- W3159898178 hasRelatedWork W2312961653 @default.
- W3159898178 hasRelatedWork W2982109291 @default.
- W3159898178 hasRelatedWork W3026976303 @default.
- W3159898178 hasRelatedWork W3200966870 @default.