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• W3159900989 abstract "Genetic hybridization of exogenous functional protein(s) of interest (POI) with silk using transgenic silkworms provides promising bio-synthesis platforms to design silk-based materials. To ensure successful hybridization, additive domains from natural silk are routinely fused with POI to form fusion POI (F-POI), but they often lead to superfluous post-translational modifications, compromise normal folding, and severely impair the activity of POI. Here, “light-clothing” strategy, i.e., rationally trimming redundant parts of additive domains, is proposed. As visualized by green fluorescent protein as marker POI, this strategy avoids supernumerary post-translational modifications in F-POI synthesis, and enables its normal secretion and extraction. Applying epidermal growth factor as model functional POI, material fabrication versatility of the extracted mixture of F-POI and silk is demonstrated. This strategy increases structural similarity between F-POI and native POI and remarkably enhances F-POI activity to the same level as commercial POI, which facilitates applications of these advanced bio-synthesis platforms for developing high-performance materials." @default.
• W3159900989 created "2021-05-10" @default.
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• W3159900989 date "2021-06-01" @default.
• W3159900989 modified "2023-10-01" @default.
• W3159900989 title "Genetic hybridization of highly active exogenous functional proteins into silk-based materials using “light-clothing” strategy" @default.
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• W3159900989 doi "https://doi.org/10.1016/j.matt.2021.03.020" @default.
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