FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159916013> ?p ?o ?g. }

• W3159916013 abstract "The HIV-1 epidemic in sub-Saharan Africa is heterogeneous with diverse unevenly distributed subtypes and regional differences in prevalence. Subtype-specific differences in disease progression rate and transmission efficiency have been reported, but the underlying biological mechanisms have not been fully characterized. Here, we tested the hypothesis that the subtypes prevalent in the East Africa, where adult prevalence rate is higher, have lower viral replication capacity (VRC) than their West African counterparts where adult prevalence rates are lower.Gag-protease sequencing was performed on 213 and 160 antiretroviral-naïve chronically infected participants from West and East Africa respectively and bioinformatic tools were used to infer subtypes and recombination patterns. VRC of patient-derived gag-protease chimeric viruses from West (n = 178) and East (n = 114) Africa were determined using a green fluorescent protein reporter-based cell assay. Subtype and regional differences in VRC and amino acid variants impacting VRC were identified by statistical methods. CRF02_AG (65%, n = 139), other recombinants (14%, n = 30) and pure subtypes (21%, n = 44) were identified in West Africa. Subtypes A1 (64%, n = 103), D (22%, n = 35), or recombinants (14%, n = 22) were identified in East Africa. Viruses from West Africa had significantly higher VRC compared to those from East Africa (p < 0.0001), with subtype-specific differences found among strains within West and East Africa (p < 0.0001). Recombination patterns showed a preference for subtypes D, G or J rather than subtype A in the p6 region of gag, with evidence that subtype-specific differences in this region impact VRC. Furthermore, the Gag A83V polymorphism was associated with reduced VRC in CRF02_AG. HLA-A*23:01 (p = 0.0014) and HLA-C*07:01 (p = 0.002) were associated with lower VRC in subtype A infected individuals from East Africa.Although prevalent viruses from West Africa displayed higher VRC than those from East Africa consistent with the hypothesis that lower VRC is associated with higher population prevalence, the predominant CRF02_AG strain in West Africa displayed higher VRC than other prevalent strains suggesting that VRC alone does not explain population prevalence. The study identified viral and host genetic determinants of virus replication capacity for HIV-1 CRF02_AG and subtype A respectively, which may have relevance for vaccine strategies." @default.
• W3159916013 created "2021-05-10" @default.
• W3159916013 creator A5012515336 @default.
• W3159916013 creator A5025796414 @default.
• W3159916013 creator A5040021477 @default.
• W3159916013 creator A5040954811 @default.
• W3159916013 creator A5044055108 @default.
• W3159916013 creator A5057477525 @default.
• W3159916013 creator A5060395528 @default.
• W3159916013 creator A5062067552 @default.
• W3159916013 creator A5082827056 @default.
• W3159916013 creator A5090295285 @default.
• W3159916013 date "2021-05-05" @default.
• W3159916013 modified "2023-10-12" @default.
• W3159916013 title "Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa" @default.
• W3159916013 cites W1849393705 @default.
• W3159916013 cites W1967892507 @default.
• W3159916013 cites W1972828904 @default.
• W3159916013 cites W1978977726 @default.
• W3159916013 cites W1982157790 @default.
• W3159916013 cites W1992953062 @default.
• W3159916013 cites W1993846907 @default.
• W3159916013 cites W1999461028 @default.
• W3159916013 cites W1999868284 @default.
• W3159916013 cites W2000800295 @default.
• W3159916013 cites W2009082439 @default.
• W3159916013 cites W2014893636 @default.
• W3159916013 cites W2026553764 @default.
• W3159916013 cites W2032317721 @default.
• W3159916013 cites W2032771361 @default.
• W3159916013 cites W2038673143 @default.
• W3159916013 cites W2043318019 @default.
• W3159916013 cites W2045551237 @default.
• W3159916013 cites W2050498291 @default.
• W3159916013 cites W2055183166 @default.
• W3159916013 cites W2062956368 @default.
• W3159916013 cites W2066354913 @default.
• W3159916013 cites W2069926681 @default.
• W3159916013 cites W2074139927 @default.
• W3159916013 cites W2094162868 @default.
• W3159916013 cites W2094193440 @default.
• W3159916013 cites W2094674887 @default.
• W3159916013 cites W2094840497 @default.
• W3159916013 cites W2099272076 @default.
• W3159916013 cites W2109130469 @default.
• W3159916013 cites W2110299975 @default.
• W3159916013 cites W2112507995 @default.
• W3159916013 cites W2112829037 @default.
• W3159916013 cites W2114088574 @default.
• W3159916013 cites W2114282483 @default.
• W3159916013 cites W2116956383 @default.
• W3159916013 cites W2123584222 @default.
• W3159916013 cites W2124996928 @default.
• W3159916013 cites W2132434777 @default.
• W3159916013 cites W2140193569 @default.
• W3159916013 cites W2143126277 @default.
• W3159916013 cites W2143298530 @default.
• W3159916013 cites W2144420913 @default.
• W3159916013 cites W2154547850 @default.
• W3159916013 cites W2155324027 @default.
• W3159916013 cites W2159181197 @default.
• W3159916013 cites W2159295367 @default.
• W3159916013 cites W2160179097 @default.
• W3159916013 cites W2162383408 @default.
• W3159916013 cites W2162727140 @default.
• W3159916013 cites W2163400707 @default.
• W3159916013 cites W2336000508 @default.
• W3159916013 cites W2460916575 @default.
• W3159916013 cites W2535014449 @default.
• W3159916013 cites W2546997765 @default.
• W3159916013 cites W2571049130 @default.
• W3159916013 cites W2605862165 @default.
• W3159916013 cites W2712490288 @default.
• W3159916013 cites W2837980584 @default.
• W3159916013 cites W2899181396 @default.
• W3159916013 cites W2903314774 @default.
• W3159916013 cites W2924309353 @default.
• W3159916013 cites W2932596990 @default.
• W3159916013 cites W2984243262 @default.
• W3159916013 cites W3023728879 @default.
• W3159916013 cites W3085675867 @default.
• W3159916013 doi "https://doi.org/10.1186/s12977-021-00554-4" @default.
• W3159916013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8097975" @default.
• W3159916013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33952315" @default.
• W3159916013 hasPublicationYear "2021" @default.
• W3159916013 type Work @default.
• W3159916013 sameAs 3159916013 @default.
• W3159916013 citedByCount "2" @default.
• W3159916013 countsByYear W31599160132022 @default.
• W3159916013 countsByYear W31599160132023 @default.
• W3159916013 crossrefType "journal-article" @default.
• W3159916013 hasAuthorship W3159916013A5012515336 @default.
• W3159916013 hasAuthorship W3159916013A5025796414 @default.
• W3159916013 hasAuthorship W3159916013A5040021477 @default.
• W3159916013 hasAuthorship W3159916013A5040954811 @default.
• W3159916013 hasAuthorship W3159916013A5044055108 @default.
• W3159916013 hasAuthorship W3159916013A5057477525 @default.
• W3159916013 hasAuthorship W3159916013A5060395528 @default.
• W3159916013 hasAuthorship W3159916013A5062067552 @default.
• W3159916013 hasAuthorship W3159916013A5082827056 @default.

• next