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- W3159928181 abstract "Abstract There are many important new advances in the development of clinically viable therapeutic options to mitigate the pathophysiology of sickle cell disease (SCD). Some of the most promising new clinical candidates reported herein directly address the primary cause of the disease by allosterically modifying sickle hemoglobin (HbS). In particular, one family of small molecules stabilizes the high oxygen (O 2 )‐affinity R‐state of the protein, which, unlike the low O 2 ‐affinity T‐state, does not present the polymerization promoting βVal6 residue. Several compounds employing this mechanism are currently at various stages of preclinical and clinical investigations. Another series of compounds that engage in a covalent bond with the surface‐located residue βCys93 of HbS, and thus destabilize the T‐state to increase Hb affinity for oxygen, is currently under preclinical development. Furthermore, promising new compounds that, similar to hydroxyurea also induce fetal Hb production, are at various stages of clinical development. Finally, compounds that target the secondary pathophysiology of SCD, including those that counter the dehydration of sickle erythrocyte; endothelial adhesion and vasculature damage; nitroxide donors providing vasodilatory and anti‐inflammatory effects; and a myriad of anti‐inflammatory and anticoagulation candidate molecules, are also being investigated in early‐ and/or late‐stage clinical trials." @default.
- W3159928181 created "2021-05-10" @default.
- W3159928181 creator A5028033960 @default.
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- W3159928181 creator A5081705281 @default.
- W3159928181 creator A5090144673 @default.
- W3159928181 date "2021-04-28" @default.
- W3159928181 modified "2023-10-16" @default.
- W3159928181 title "Therapeutic Strategies for the Treatment of Sickle Cell Disease" @default.
- W3159928181 cites W117828388 @default.
- W3159928181 cites W1492560350 @default.
- W3159928181 cites W1499254173 @default.
- W3159928181 cites W1514310807 @default.
- W3159928181 cites W1515900859 @default.
- W3159928181 cites W1517621505 @default.
- W3159928181 cites W1519171456 @default.
- W3159928181 cites W1524961767 @default.
- W3159928181 cites W1528569576 @default.
- W3159928181 cites W153444934 @default.
- W3159928181 cites W1545266136 @default.
- W3159928181 cites W1562443263 @default.
- W3159928181 cites W1596260168 @default.
- W3159928181 cites W1693240140 @default.
- W3159928181 cites W17161741 @default.
- W3159928181 cites W1812182671 @default.
- W3159928181 cites W1844327653 @default.
- W3159928181 cites W1847050890 @default.
- W3159928181 cites W187213942 @default.
- W3159928181 cites W1943358986 @default.
- W3159928181 cites W1948960263 @default.
- W3159928181 cites W1955305991 @default.
- W3159928181 cites W1965875500 @default.
- W3159928181 cites W1966351348 @default.
- W3159928181 cites W1968165696 @default.
- W3159928181 cites W1968642156 @default.
- W3159928181 cites W1969553017 @default.
- W3159928181 cites W1971000283 @default.
- W3159928181 cites W1972024533 @default.
- W3159928181 cites W1972157068 @default.
- W3159928181 cites W1972297061 @default.
- W3159928181 cites W1972933434 @default.
- W3159928181 cites W1973018387 @default.
- W3159928181 cites W1975272363 @default.
- W3159928181 cites W1975364175 @default.
- W3159928181 cites W1976466808 @default.
- W3159928181 cites W1976961324 @default.
- W3159928181 cites W1977508606 @default.
- W3159928181 cites W1978006346 @default.
- W3159928181 cites W1978485157 @default.
- W3159928181 cites W1980043217 @default.
- W3159928181 cites W1980333674 @default.
- W3159928181 cites W1980754701 @default.
- W3159928181 cites W1980779308 @default.
- W3159928181 cites W1981857877 @default.
- W3159928181 cites W1982440289 @default.
- W3159928181 cites W1982738145 @default.
- W3159928181 cites W1983297963 @default.
- W3159928181 cites W1986796600 @default.
- W3159928181 cites W1987037884 @default.
- W3159928181 cites W1987484621 @default.
- W3159928181 cites W1987671956 @default.
- W3159928181 cites W1988559818 @default.
- W3159928181 cites W1990337124 @default.
- W3159928181 cites W1990599619 @default.
- W3159928181 cites W1991301985 @default.
- W3159928181 cites W1992274074 @default.
- W3159928181 cites W1993862026 @default.
- W3159928181 cites W1995325755 @default.
- W3159928181 cites W1995698717 @default.
- W3159928181 cites W1995931298 @default.
- W3159928181 cites W1996662512 @default.
- W3159928181 cites W1996980138 @default.
- W3159928181 cites W2000092137 @default.
- W3159928181 cites W2002213560 @default.
- W3159928181 cites W200247425 @default.
- W3159928181 cites W2002783428 @default.
- W3159928181 cites W2003593234 @default.
- W3159928181 cites W2006231916 @default.
- W3159928181 cites W2008170620 @default.
- W3159928181 cites W2009701238 @default.
- W3159928181 cites W2010407535 @default.
- W3159928181 cites W2010859896 @default.
- W3159928181 cites W2010897501 @default.
- W3159928181 cites W2012484534 @default.
- W3159928181 cites W2013392029 @default.
- W3159928181 cites W2017243241 @default.
- W3159928181 cites W2018540939 @default.
- W3159928181 cites W2019134707 @default.
- W3159928181 cites W2021391196 @default.
- W3159928181 cites W2022705281 @default.
- W3159928181 cites W2024076511 @default.
- W3159928181 cites W2024939832 @default.
- W3159928181 cites W2025298055 @default.
- W3159928181 cites W2026788098 @default.
- W3159928181 cites W2026814520 @default.
- W3159928181 cites W2027662398 @default.
- W3159928181 cites W2027816595 @default.