FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159968307> ?p ?o ?g. }

• W3159968307 endingPage "2102" @default.
• W3159968307 startingPage "2102" @default.
• W3159968307 abstract "The objective is to develop a multivariable risk model for the non-invasive detection of prostate cancer prior to biopsy by integrating information from clinically available parameters, Engrailed-2 (EN2) whole-urine protein levels and data from urinary cell-free RNA. Post-digital-rectal examination urine samples collected as part of the Movember Global Action Plan 1 study which has been analysed for both cell-free-RNA and EN2 protein levels were chosen to be integrated with clinical parameters (n = 207). A previously described robust feature selection framework incorporating bootstrap resampling and permutation was applied to the data to generate an optimal feature set for use in Random Forest models for prediction. The fully integrated model was named ExoGrail, and the out-of-bag predictions were used to evaluate the diagnostic potential of the risk model. ExoGrail risk (range 0–1) was able to determine the outcome of an initial trans-rectal ultrasound guided (TRUS) biopsy more accurately than clinical standards of care, predicting the presence of any cancer with an area under the receiver operator curve (AUC) = 0.89 (95% confidence interval(CI): 0.85–0.94), and discriminating more aggressive Gleason ≥ 3 + 4 disease returning an AUC = 0.84 (95% CI: 0.78–0.89). The likelihood of more aggressive disease being detected significantly increased as ExoGrail risk score increased (Odds Ratio (OR) = 2.21 per 0.1 ExoGrail increase, 95% CI: 1.91–2.59). Decision curve analysis of the net benefit of ExoGrail showed the potential to reduce the numbers of unnecessary biopsies by 35% when compared to current standards of care. Integration of information from multiple, non-invasive biomarker sources has the potential to greatly improve how patients with a clinical suspicion of prostate cancer are risk-assessed prior to an invasive biopsy." @default.
• W3159968307 created "2021-05-10" @default.
• W3159968307 creator A5016195737 @default.
• W3159968307 creator A5027776246 @default.
• W3159968307 creator A5041440680 @default.
• W3159968307 creator A5058004140 @default.
• W3159968307 creator A5067211956 @default.
• W3159968307 creator A5079229756 @default.
• W3159968307 creator A5088971353 @default.
• W3159968307 date "2021-04-27" @default.
• W3159968307 modified "2023-10-07" @default.
• W3159968307 title "Integration of Urinary EN2 Protein & Cell-Free RNA Data in the Development of a Multivariable Risk Model for the Detection of Prostate Cancer Prior to Biopsy" @default.
• W3159968307 cites W1573867559 @default.
• W3159968307 cites W1594862406 @default.
• W3159968307 cites W1607545398 @default.
• W3159968307 cites W1989403098 @default.
• W3159968307 cites W2000194744 @default.
• W3159968307 cites W2006617902 @default.
• W3159968307 cites W2027576789 @default.
• W3159968307 cites W2030687108 @default.
• W3159968307 cites W2039651067 @default.
• W3159968307 cites W2043672855 @default.
• W3159968307 cites W2045030989 @default.
• W3159968307 cites W2106833357 @default.
• W3159968307 cites W2132803044 @default.
• W3159968307 cites W2132904157 @default.
• W3159968307 cites W2141019253 @default.
• W3159968307 cites W2156665896 @default.
• W3159968307 cites W2158099560 @default.
• W3159968307 cites W2168391852 @default.
• W3159968307 cites W2296262901 @default.
• W3159968307 cites W2316242722 @default.
• W3159968307 cites W2333136497 @default.
• W3159968307 cites W2336471292 @default.
• W3159968307 cites W2341689870 @default.
• W3159968307 cites W2343495497 @default.
• W3159968307 cites W2417116130 @default.
• W3159968307 cites W2511755939 @default.
• W3159968307 cites W2556512152 @default.
• W3159968307 cites W2577453388 @default.
• W3159968307 cites W2587657917 @default.
• W3159968307 cites W2593379353 @default.
• W3159968307 cites W2760504023 @default.
• W3159968307 cites W2772104639 @default.
• W3159968307 cites W2775769660 @default.
• W3159968307 cites W2786693279 @default.
• W3159968307 cites W2791546899 @default.
• W3159968307 cites W2900163497 @default.
• W3159968307 cites W2900597399 @default.
• W3159968307 cites W2911964244 @default.
• W3159968307 cites W2923244828 @default.
• W3159968307 cites W2941995248 @default.
• W3159968307 cites W2946274893 @default.
• W3159968307 cites W2952837230 @default.
• W3159968307 cites W2955616988 @default.
• W3159968307 cites W2990412821 @default.
• W3159968307 cites W3000744571 @default.
• W3159968307 cites W3006298732 @default.
• W3159968307 cites W3010255007 @default.
• W3159968307 doi "https://doi.org/10.3390/cancers13092102" @default.
• W3159968307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8123800" @default.
• W3159968307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33925381" @default.
• W3159968307 hasPublicationYear "2021" @default.
• W3159968307 type Work @default.
• W3159968307 sameAs 3159968307 @default.
• W3159968307 citedByCount "4" @default.
• W3159968307 countsByYear W31599683072022 @default.
• W3159968307 countsByYear W31599683072023 @default.
• W3159968307 crossrefType "journal-article" @default.
• W3159968307 hasAuthorship W3159968307A5016195737 @default.
• W3159968307 hasAuthorship W3159968307A5027776246 @default.
• W3159968307 hasAuthorship W3159968307A5041440680 @default.
• W3159968307 hasAuthorship W3159968307A5058004140 @default.
• W3159968307 hasAuthorship W3159968307A5067211956 @default.
• W3159968307 hasAuthorship W3159968307A5079229756 @default.
• W3159968307 hasAuthorship W3159968307A5088971353 @default.
• W3159968307 hasBestOaLocation W31599683071 @default.
• W3159968307 hasConcept C11413529 @default.
• W3159968307 hasConcept C121608353 @default.
• W3159968307 hasConcept C126322002 @default.
• W3159968307 hasConcept C143998085 @default.
• W3159968307 hasConcept C156957248 @default.
• W3159968307 hasConcept C2775934546 @default.
• W3159968307 hasConcept C2780192828 @default.
• W3159968307 hasConcept C41008148 @default.
• W3159968307 hasConcept C44249647 @default.
• W3159968307 hasConcept C58471807 @default.
• W3159968307 hasConcept C71924100 @default.
• W3159968307 hasConceptScore W3159968307C11413529 @default.
• W3159968307 hasConceptScore W3159968307C121608353 @default.
• W3159968307 hasConceptScore W3159968307C126322002 @default.
• W3159968307 hasConceptScore W3159968307C143998085 @default.
• W3159968307 hasConceptScore W3159968307C156957248 @default.
• W3159968307 hasConceptScore W3159968307C2775934546 @default.
• W3159968307 hasConceptScore W3159968307C2780192828 @default.
• W3159968307 hasConceptScore W3159968307C41008148 @default.
• W3159968307 hasConceptScore W3159968307C44249647 @default.
• W3159968307 hasConceptScore W3159968307C58471807 @default.

• next