Matches in SemOpenAlex for { <https://semopenalex.org/work/W3159968794> ?p ?o ?g. }
- W3159968794 endingPage "3694" @default.
- W3159968794 startingPage "3680" @default.
- W3159968794 abstract "Cutaneous squamous cell carcinoma (cSCC) ranks second in the frequency of all skin cancers. The balance between keratinocyte proliferation and differentiation is disrupted in the pathological development of cSCC. DLX3 is a homeobox transcription factor which plays pivotal roles in embryonic development and epidermal homeostasis. To investigate the impact of DLX3 expression on cSCC prognosis, we carried out clinicopathologic analysis of DLX3 expression which showed statistical correlation between tumors of higher pathologic grade and levels of DLX3 protein expression. Further, Kaplan-Meier survival curve analysis demonstrated that low DLX3 expression correlated with poor patient survival. To model the function of Dlx3 in skin tumorigenesis, a two-stage dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA) study was performed on mice genetically depleted of Dlx3 in skin epithelium (Dlx3cKO). Dlx3cKO mice developed significantly more tumors, with more rapid tumorigenesis compared to control mice. In Dlx3cKO mice treated only with DMBA, tumors developed after ~16 weeks suggesting that loss of Dlx3 has a tumor promoting effect. Whole transcriptome analysis of tumor and skin tissue from our mouse model revealed spontaneous activation of the EGFR-ERBB2 pathway in the absence of Dlx3. Together, our findings from human and mouse model system support a tumor suppressive function for DLX3 in skin and underscore the efficacy of therapeutic approaches that target EGFR-ERBB2 pathway." @default.
- W3159968794 created "2021-05-10" @default.
- W3159968794 creator A5006526481 @default.
- W3159968794 creator A5012558330 @default.
- W3159968794 creator A5026656618 @default.
- W3159968794 creator A5031676789 @default.
- W3159968794 creator A5037924434 @default.
- W3159968794 creator A5043173570 @default.
- W3159968794 creator A5044927587 @default.
- W3159968794 creator A5045531616 @default.
- W3159968794 creator A5046188190 @default.
- W3159968794 creator A5060478731 @default.
- W3159968794 creator A5077212635 @default.
- W3159968794 creator A5078434832 @default.
- W3159968794 creator A5079678551 @default.
- W3159968794 creator A5082094461 @default.
- W3159968794 date "2021-05-04" @default.
- W3159968794 modified "2023-10-16" @default.
- W3159968794 title "Loss of DLX3 tumor suppressive function promotes progression of SCC through EGFR–ERBB2 pathway" @default.
- W3159968794 cites W1494864623 @default.
- W3159968794 cites W1591403532 @default.
- W3159968794 cites W1897965600 @default.
- W3159968794 cites W1966448521 @default.
- W3159968794 cites W1980300191 @default.
- W3159968794 cites W1988141621 @default.
- W3159968794 cites W1997184970 @default.
- W3159968794 cites W2008663430 @default.
- W3159968794 cites W2011566712 @default.
- W3159968794 cites W2016710415 @default.
- W3159968794 cites W2017191244 @default.
- W3159968794 cites W2019772485 @default.
- W3159968794 cites W2020459118 @default.
- W3159968794 cites W2037351324 @default.
- W3159968794 cites W2037395954 @default.
- W3159968794 cites W2046698244 @default.
- W3159968794 cites W2052897162 @default.
- W3159968794 cites W2066171378 @default.
- W3159968794 cites W2068494490 @default.
- W3159968794 cites W2079286299 @default.
- W3159968794 cites W2084418462 @default.
- W3159968794 cites W2085512015 @default.
- W3159968794 cites W2090732437 @default.
- W3159968794 cites W2096052997 @default.
- W3159968794 cites W2101034386 @default.
- W3159968794 cites W2105950379 @default.
- W3159968794 cites W2107277218 @default.
- W3159968794 cites W2111814826 @default.
- W3159968794 cites W2131596612 @default.
- W3159968794 cites W2131757723 @default.
- W3159968794 cites W2134691008 @default.
- W3159968794 cites W2143902340 @default.
- W3159968794 cites W2146556279 @default.
- W3159968794 cites W2150058256 @default.
- W3159968794 cites W2166505025 @default.
- W3159968794 cites W2192080449 @default.
- W3159968794 cites W2210251023 @default.
- W3159968794 cites W2328246719 @default.
- W3159968794 cites W2560257166 @default.
- W3159968794 cites W2587737301 @default.
- W3159968794 cites W2773902754 @default.
- W3159968794 cites W2782712404 @default.
- W3159968794 cites W2893367264 @default.
- W3159968794 cites W2918502945 @default.
- W3159968794 cites W2961375208 @default.
- W3159968794 doi "https://doi.org/10.1038/s41388-021-01802-9" @default.
- W3159968794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8159909" @default.
- W3159968794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33947961" @default.
- W3159968794 hasPublicationYear "2021" @default.
- W3159968794 type Work @default.
- W3159968794 sameAs 3159968794 @default.
- W3159968794 citedByCount "6" @default.
- W3159968794 countsByYear W31599687942021 @default.
- W3159968794 countsByYear W31599687942022 @default.
- W3159968794 countsByYear W31599687942023 @default.
- W3159968794 crossrefType "journal-article" @default.
- W3159968794 hasAuthorship W3159968794A5006526481 @default.
- W3159968794 hasAuthorship W3159968794A5012558330 @default.
- W3159968794 hasAuthorship W3159968794A5026656618 @default.
- W3159968794 hasAuthorship W3159968794A5031676789 @default.
- W3159968794 hasAuthorship W3159968794A5037924434 @default.
- W3159968794 hasAuthorship W3159968794A5043173570 @default.
- W3159968794 hasAuthorship W3159968794A5044927587 @default.
- W3159968794 hasAuthorship W3159968794A5045531616 @default.
- W3159968794 hasAuthorship W3159968794A5046188190 @default.
- W3159968794 hasAuthorship W3159968794A5060478731 @default.
- W3159968794 hasAuthorship W3159968794A5077212635 @default.
- W3159968794 hasAuthorship W3159968794A5078434832 @default.
- W3159968794 hasAuthorship W3159968794A5079678551 @default.
- W3159968794 hasAuthorship W3159968794A5082094461 @default.
- W3159968794 hasBestOaLocation W31599687942 @default.
- W3159968794 hasConcept C121608353 @default.
- W3159968794 hasConcept C126322002 @default.
- W3159968794 hasConcept C2778287671 @default.
- W3159968794 hasConcept C2778938436 @default.
- W3159968794 hasConcept C2779256057 @default.
- W3159968794 hasConcept C502942594 @default.
- W3159968794 hasConcept C54355233 @default.
- W3159968794 hasConcept C555283112 @default.