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• W3159970907 abstract "Linker histones H1 are essential chromatin components that exist as multiple developmentally regulated variants. In metazoans, specific H1s are expressed during germline development in a tightly regulated manner. However, the mechanisms governing their stage-dependent expression are poorly understood. Here, we address this question in Drosophila, which encodes for a single germline-specific dBigH1 linker histone. We show that during female germline lineage differentiation, dBigH1 is expressed in germ stem cells and cystoblasts, becomes silenced during transit-amplifying (TA) cystocytes divisions to resume expression after proliferation stops and differentiation starts, when it progressively accumulates in the oocyte. We find that dBigH1 silencing during TA divisions is post-transcriptional and depends on the tumour suppressor Brain tumour (Brat), an essential RNA-binding protein that regulates mRNA translation and stability. Like other oocyte-specific variants, dBigH1 is maternally expressed during early embryogenesis until it is replaced by somatic dH1 at the maternal-to-zygotic transition (MZT). Brat also mediates dBigH1 silencing at MZT. Finally, we discuss the situation in testes, where Brat is not expressed, but dBigH1 is translationally silenced too." @default.
• W3159970907 created "2021-05-10" @default.
• W3159970907 creator A5007262112 @default.
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• W3159970907 date "2021-05-01" @default.
• W3159970907 modified "2023-10-17" @default.
• W3159970907 title "The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the <i>Drosophila</i> female germline and the early embryo" @default.
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• W3159970907 doi "https://doi.org/10.1098/rsob.200408" @default.
• W3159970907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8097206" @default.
• W3159970907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33947246" @default.
• W3159970907 hasPublicationYear "2021" @default.
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