FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160010868> ?p ?o ?g. }

• W3160010868 endingPage "14257" @default.
• W3160010868 startingPage "14234" @default.
• W3160010868 abstract "Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disease without a clear mechanism or drugs for treatment. Therefore, it is crucial to reveal the underlying molecular mechanism and identify potential drugs for PAH. In this study, we first integrated three human lung tissue datasets (GSE113439, GSE53408, GSE117261) from GEO. A total of 151 differentially expressed genes (DEGs) were screened, followed by KEGG and GO enrichment analyses and PPI network construction. Five hub genes (CSF3R, NT5E, ANGPT2, FGF7, and CXCL9) were identified by Cytoscape (Cytohubba). GSEA and GSVA were performed for each hub gene to uncover the potential mechanism. Moreover, to repurpose known and therapeutic drugs, the CMap database was retrieved, and nine candidate compounds (lypressin, ruxolitinib, triclabendazole, L-BSO, tiaprofenic acid, AT-9283, QL-X-138, huperzine-a, and L-741742) with a high level of confidence were obtained. Then ruxolitinib was selected to perform molecular docking simulations with ANGPT2, FGF7, NT5E, CSF3R, JAK1, JAK2, JAK3, TYK2. A certain concentration of ruxolitinib could inhibit the proliferation and migration of rat pulmonary artery smooth muscle cells (rPASMCs) in vitro. Together, these analyses principally identified CSF3R, NT5E, ANGPT2, FGF7 and CXCL9 as candidate biomarkers of PAH, and ruxolitinib might exert promising therapeutic action for PAH." @default.
• W3160010868 created "2021-05-24" @default.
• W3160010868 creator A5005985060 @default.
• W3160010868 creator A5018863416 @default.
• W3160010868 creator A5020568031 @default.
• W3160010868 creator A5021206091 @default.
• W3160010868 creator A5041044652 @default.
• W3160010868 creator A5041058780 @default.
• W3160010868 creator A5046978287 @default.
• W3160010868 creator A5071998737 @default.
• W3160010868 creator A5075828120 @default.
• W3160010868 creator A5088141052 @default.
• W3160010868 date "2021-05-18" @default.
• W3160010868 modified "2023-10-16" @default.
• W3160010868 title "Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension" @default.
• W3160010868 cites W1757990252 @default.
• W3160010868 cites W1915697415 @default.
• W3160010868 cites W1990024433 @default.
• W3160010868 cites W2000050480 @default.
• W3160010868 cites W2007413373 @default.
• W3160010868 cites W2007868610 @default.
• W3160010868 cites W2010457001 @default.
• W3160010868 cites W2031547741 @default.
• W3160010868 cites W2035618305 @default.
• W3160010868 cites W2038901354 @default.
• W3160010868 cites W2064236588 @default.
• W3160010868 cites W2070022895 @default.
• W3160010868 cites W2077952441 @default.
• W3160010868 cites W2080934115 @default.
• W3160010868 cites W2103912979 @default.
• W3160010868 cites W2105668062 @default.
• W3160010868 cites W2112404540 @default.
• W3160010868 cites W2116634113 @default.
• W3160010868 cites W2118258530 @default.
• W3160010868 cites W2129899732 @default.
• W3160010868 cites W2130410032 @default.
• W3160010868 cites W2134186455 @default.
• W3160010868 cites W2139316151 @default.
• W3160010868 cites W2146512944 @default.
• W3160010868 cites W2151806709 @default.
• W3160010868 cites W2155911326 @default.
• W3160010868 cites W2159707944 @default.
• W3160010868 cites W2167717876 @default.
• W3160010868 cites W2169353806 @default.
• W3160010868 cites W2306104084 @default.
• W3160010868 cites W2322665035 @default.
• W3160010868 cites W2337617951 @default.
• W3160010868 cites W2413156075 @default.
• W3160010868 cites W2463634719 @default.
• W3160010868 cites W2547499746 @default.
• W3160010868 cites W2587019934 @default.
• W3160010868 cites W2589122495 @default.
• W3160010868 cites W2612467560 @default.
• W3160010868 cites W2792635689 @default.
• W3160010868 cites W2807168854 @default.
• W3160010868 cites W2888126954 @default.
• W3160010868 cites W2895934611 @default.
• W3160010868 cites W2898136244 @default.
• W3160010868 cites W2899070097 @default.
• W3160010868 cites W2900569176 @default.
• W3160010868 cites W2900612779 @default.
• W3160010868 cites W2913617128 @default.
• W3160010868 cites W2919470142 @default.
• W3160010868 cites W2922367794 @default.
• W3160010868 cites W2966972334 @default.
• W3160010868 cites W2969044846 @default.
• W3160010868 cites W2973523639 @default.
• W3160010868 cites W3010903057 @default.
• W3160010868 cites W3032071647 @default.
• W3160010868 cites W3046494418 @default.
• W3160010868 cites W3093166712 @default.
• W3160010868 doi "https://doi.org/10.18632/aging.203040" @default.
• W3160010868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8202883" @default.
• W3160010868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34016786" @default.
• W3160010868 hasPublicationYear "2021" @default.
• W3160010868 type Work @default.
• W3160010868 sameAs 3160010868 @default.
• W3160010868 citedByCount "15" @default.
• W3160010868 countsByYear W31600108682022 @default.
• W3160010868 countsByYear W31600108682023 @default.
• W3160010868 crossrefType "journal-article" @default.
• W3160010868 hasAuthorship W3160010868A5005985060 @default.
• W3160010868 hasAuthorship W3160010868A5018863416 @default.
• W3160010868 hasAuthorship W3160010868A5020568031 @default.
• W3160010868 hasAuthorship W3160010868A5021206091 @default.
• W3160010868 hasAuthorship W3160010868A5041044652 @default.
• W3160010868 hasAuthorship W3160010868A5041058780 @default.
• W3160010868 hasAuthorship W3160010868A5046978287 @default.
• W3160010868 hasAuthorship W3160010868A5071998737 @default.
• W3160010868 hasAuthorship W3160010868A5075828120 @default.
• W3160010868 hasAuthorship W3160010868A5088141052 @default.
• W3160010868 hasBestOaLocation W31600108681 @default.
• W3160010868 hasConcept C104317684 @default.
• W3160010868 hasConcept C111472728 @default.
• W3160010868 hasConcept C126322002 @default.
• W3160010868 hasConcept C138885662 @default.
• W3160010868 hasConcept C150194340 @default.
• W3160010868 hasConcept C152724338 @default.

• next