FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160080178> ?p ?o ?g. }

• W3160080178 abstract "ABSTRACT The classical view of oxidative phosphorylation is that a proton motive force PMF generated by the respiratory chain complexes fuels ATP synthesis. Under glycolytic conditions, ATP synthase in its reverse mode also can contribute to the PMF. Here, we dissected the two functions of ATP synthase and the role of its inhibitory factor 1 (IF1) under different metabolic conditions in detail. pH profiles of mitochondrial sub-compartments were recorded with high spatial resolution in live mammalian cells by positioning a pH-sensor directly at F 1 and F O of ATP synthase, complex IV and in the matrix. Our results clearly show that ATP synthase activity is substantially controlling the PMF and that IF1 is essential under OXPHOS conditions to prevent reverse ATP synthase activity due to an almost negligible ΔpH. GRAPHICAL ABSTRACT HIGHLIGHTS The ΔpH along and across the inner mitochondrial membrane is not homogeneous The proton motive force at cristae tips is controlled by F 1 F O ATP synthase Under OXPHOS conditions, the pH difference between F O and F 1 of active ATP synthase is almost negligible (1.2 proton vs. 1 proton equivalent) IF1 is required to prevent the onset of ATP hydrolysis under OXPHOS conditions" @default.
• W3160080178 created "2021-05-24" @default.
• W3160080178 creator A5021761112 @default.
• W3160080178 creator A5038088654 @default.
• W3160080178 creator A5047927000 @default.
• W3160080178 creator A5065789246 @default.
• W3160080178 date "2021-02-11" @default.
• W3160080178 modified "2023-10-16" @default.
• W3160080178 title "Mitochondrial F₁F_O ATP synthase determines the local proton motive force in cristae tips" @default.
• W3160080178 cites W1919142731 @default.
• W3160080178 cites W1964126982 @default.
• W3160080178 cites W1987695736 @default.
• W3160080178 cites W1992196716 @default.
• W3160080178 cites W1996440573 @default.
• W3160080178 cites W1996652459 @default.
• W3160080178 cites W1999040292 @default.
• W3160080178 cites W2003638303 @default.
• W3160080178 cites W2016166286 @default.
• W3160080178 cites W2020816696 @default.
• W3160080178 cites W2028612460 @default.
• W3160080178 cites W2029663082 @default.
• W3160080178 cites W2035409739 @default.
• W3160080178 cites W2052844218 @default.
• W3160080178 cites W2077919955 @default.
• W3160080178 cites W2077996001 @default.
• W3160080178 cites W2079594619 @default.
• W3160080178 cites W2090734611 @default.
• W3160080178 cites W2093921916 @default.
• W3160080178 cites W2111204365 @default.
• W3160080178 cites W2137564359 @default.
• W3160080178 cites W2142577446 @default.
• W3160080178 cites W2170676142 @default.
• W3160080178 cites W2259219320 @default.
• W3160080178 cites W2586118651 @default.
• W3160080178 cites W2592588133 @default.
• W3160080178 cites W2892306065 @default.
• W3160080178 cites W2914746958 @default.
• W3160080178 cites W2944341962 @default.
• W3160080178 cites W2961103900 @default.
• W3160080178 cites W3001989577 @default.
• W3160080178 doi "https://doi.org/10.1101/2021.02.11.430746" @default.
• W3160080178 hasPublicationYear "2021" @default.
• W3160080178 type Work @default.
• W3160080178 sameAs 3160080178 @default.
• W3160080178 citedByCount "1" @default.
• W3160080178 countsByYear W31600801782021 @default.
• W3160080178 crossrefType "posted-content" @default.
• W3160080178 hasAuthorship W3160080178A5021761112 @default.
• W3160080178 hasAuthorship W3160080178A5038088654 @default.
• W3160080178 hasAuthorship W3160080178A5047927000 @default.
• W3160080178 hasAuthorship W3160080178A5065789246 @default.
• W3160080178 hasBestOaLocation W31600801781 @default.
• W3160080178 hasConcept C100206155 @default.
• W3160080178 hasConcept C101692577 @default.
• W3160080178 hasConcept C104317684 @default.
• W3160080178 hasConcept C112243037 @default.
• W3160080178 hasConcept C11701378 @default.
• W3160080178 hasConcept C119120687 @default.
• W3160080178 hasConcept C121332964 @default.
• W3160080178 hasConcept C12554922 @default.
• W3160080178 hasConcept C141315368 @default.
• W3160080178 hasConcept C171357686 @default.
• W3160080178 hasConcept C181199279 @default.
• W3160080178 hasConcept C185592680 @default.
• W3160080178 hasConcept C191678065 @default.
• W3160080178 hasConcept C20251656 @default.
• W3160080178 hasConcept C23265538 @default.
• W3160080178 hasConcept C28859421 @default.
• W3160080178 hasConcept C41625074 @default.
• W3160080178 hasConcept C54516573 @default.
• W3160080178 hasConcept C55493867 @default.
• W3160080178 hasConcept C57600042 @default.
• W3160080178 hasConcept C62520636 @default.
• W3160080178 hasConcept C686708 @default.
• W3160080178 hasConcept C69305403 @default.
• W3160080178 hasConcept C86803240 @default.
• W3160080178 hasConcept C90424259 @default.
• W3160080178 hasConcept C98539663 @default.
• W3160080178 hasConceptScore W3160080178C100206155 @default.
• W3160080178 hasConceptScore W3160080178C101692577 @default.
• W3160080178 hasConceptScore W3160080178C104317684 @default.
• W3160080178 hasConceptScore W3160080178C112243037 @default.
• W3160080178 hasConceptScore W3160080178C11701378 @default.
• W3160080178 hasConceptScore W3160080178C119120687 @default.
• W3160080178 hasConceptScore W3160080178C121332964 @default.
• W3160080178 hasConceptScore W3160080178C12554922 @default.
• W3160080178 hasConceptScore W3160080178C141315368 @default.
• W3160080178 hasConceptScore W3160080178C171357686 @default.
• W3160080178 hasConceptScore W3160080178C181199279 @default.
• W3160080178 hasConceptScore W3160080178C185592680 @default.
• W3160080178 hasConceptScore W3160080178C191678065 @default.
• W3160080178 hasConceptScore W3160080178C20251656 @default.
• W3160080178 hasConceptScore W3160080178C23265538 @default.
• W3160080178 hasConceptScore W3160080178C28859421 @default.
• W3160080178 hasConceptScore W3160080178C41625074 @default.
• W3160080178 hasConceptScore W3160080178C54516573 @default.
• W3160080178 hasConceptScore W3160080178C55493867 @default.
• W3160080178 hasConceptScore W3160080178C57600042 @default.
• W3160080178 hasConceptScore W3160080178C62520636 @default.
• W3160080178 hasConceptScore W3160080178C686708 @default.

• next