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• W3160091499 abstract "Amyotrophic lateral sclerosis (ALS) is a devastating disease that is characterized by the loss of muscle control due to the degeneration of motor neurons in the brain and the spinal cord. Although it's the motor neurons that die in ALS, non-neuronal cells are also involved in disease pathogenesis. Glial cells, including microglia, astrocytes, and oligodendrocytes, surround and support motor neurons, and pathological changes of glia have been unequivocally linked to the onset and progression of ALS. Microglia and astrocyte activation in particular are considered a hallmark feature and are directly associated with ALS neurodegeneration. Nevertheless, the precise contributions of glial cells to disease pathogenesis in ALS and neurodegeneration remain elusive. One reason is that the evolving contribution of glial cells is likely to change during the course of the disease and therefore is often difficult to track longitudinally. In this chapter, we will summarize and review the current evidence for the effects of astrocytes, microglia, and oligodendrocytes on motor neuron survival in ALS and discuss their relevance for the different disease subtypes. We also discuss how modulating neuron–glia interactions might have important therapeutic implications by highlighting some of their fundamental regulatory functions in ALS pathogenesis. We review the popular term neuroinflammation in relation to ALS. A deeper understanding of how we can preserve the protective function of glial cells while suppressing their potentially toxic behavior might offer new avenues for combinatorial therapies that help to delay or ultimately stop the rapid progression of neurodegeneration." @default.
• W3160091499 created "2021-05-24" @default.
• W3160091499 creator A5007307080 @default.
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• W3160091499 creator A5062998368 @default.
• W3160091499 date "2021-04-27" @default.
• W3160091499 modified "2023-10-16" @default.
• W3160091499 title "Evidence for a Growing Involvement of Glia in Amyotrophic Lateral Sclerosis" @default.
• W3160091499 cites W1503916499 @default.
• W3160091499 cites W1526220254 @default.
• W3160091499 cites W1571682533 @default.
• W3160091499 cites W1594747697 @default.
• W3160091499 cites W1823461212 @default.
• W3160091499 cites W1850621193 @default.
• W3160091499 cites W1910374374 @default.
• W3160091499 cites W1910977525 @default.
• W3160091499 cites W1917568245 @default.
• W3160091499 cites W1931794171 @default.
• W3160091499 cites W1949812121 @default.
• W3160091499 cites W1969387798 @default.
• W3160091499 cites W1970433280 @default.
• W3160091499 cites W1971516308 @default.
• W3160091499 cites W1974485241 @default.
• W3160091499 cites W1976765363 @default.
• W3160091499 cites W1980789245 @default.
• W3160091499 cites W1981912182 @default.
• W3160091499 cites W1982725145 @default.
• W3160091499 cites W1987138690 @default.
• W3160091499 cites W1994246241 @default.
• W3160091499 cites W1999030539 @default.
• W3160091499 cites W2002977156 @default.
• W3160091499 cites W2004415828 @default.
• W3160091499 cites W2018558728 @default.
• W3160091499 cites W2019454304 @default.
• W3160091499 cites W2019706623 @default.
• W3160091499 cites W2021374516 @default.
• W3160091499 cites W2023769419 @default.
• W3160091499 cites W2024957504 @default.
• W3160091499 cites W2027047473 @default.
• W3160091499 cites W2027433665 @default.
• W3160091499 cites W2029589408 @default.
• W3160091499 cites W2029607802 @default.
• W3160091499 cites W2030194678 @default.
• W3160091499 cites W2032706712 @default.
• W3160091499 cites W2033158384 @default.
• W3160091499 cites W2033966441 @default.
• W3160091499 cites W2038811384 @default.
• W3160091499 cites W2039149300 @default.
• W3160091499 cites W2040773899 @default.
• W3160091499 cites W2047585900 @default.
• W3160091499 cites W2051387942 @default.
• W3160091499 cites W2053863700 @default.
• W3160091499 cites W2058669152 @default.
• W3160091499 cites W2059355164 @default.
• W3160091499 cites W2060127255 @default.
• W3160091499 cites W2066828509 @default.
• W3160091499 cites W2066943555 @default.
• W3160091499 cites W2067015275 @default.
• W3160091499 cites W2069893872 @default.
• W3160091499 cites W2071591138 @default.
• W3160091499 cites W2074661552 @default.
• W3160091499 cites W2075691498 @default.
• W3160091499 cites W2084942172 @default.
• W3160091499 cites W2086383999 @default.
• W3160091499 cites W2093791199 @default.
• W3160091499 cites W2094992876 @default.
• W3160091499 cites W2099671775 @default.
• W3160091499 cites W2101321540 @default.
• W3160091499 cites W2106083699 @default.
• W3160091499 cites W2108191354 @default.
• W3160091499 cites W2114080032 @default.
• W3160091499 cites W2119958966 @default.
• W3160091499 cites W2121726351 @default.
• W3160091499 cites W2131198526 @default.
• W3160091499 cites W2135522980 @default.
• W3160091499 cites W2137199534 @default.
• W3160091499 cites W2138384626 @default.
• W3160091499 cites W2139772062 @default.
• W3160091499 cites W2141763708 @default.
• W3160091499 cites W2144507462 @default.
• W3160091499 cites W2144536780 @default.
• W3160091499 cites W2146546145 @default.
• W3160091499 cites W2146946048 @default.
• W3160091499 cites W2149497936 @default.
• W3160091499 cites W2154375184 @default.
• W3160091499 cites W2156298828 @default.
• W3160091499 cites W2161938104 @default.
• W3160091499 cites W2163751922 @default.
• W3160091499 cites W2166043619 @default.
• W3160091499 cites W2167912995 @default.
• W3160091499 cites W2296809607 @default.
• W3160091499 cites W2304886140 @default.
• W3160091499 cites W2370677464 @default.
• W3160091499 cites W2460035459 @default.

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