Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160110271> ?p ?o ?g. }
- W3160110271 endingPage "6565" @default.
- W3160110271 startingPage "6549" @default.
- W3160110271 abstract "Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC is involved in multiple diseases and conditions including Alzheimer’s disease, Huntington’s disease, melanomas, thyroid carcinomas, accelerated atherosclerosis, septic arthritics, etc. This upregulation catalyzes the generation of modified mediators such as pE-amyloid beta (Aß) and pE-chemokine ligand 2 (CCL2) peptides. Not surprisingly, QC has emerged as a reasonable target for the development of therapeutics to combat these diseases and conditions. In this manuscript the deleterious effects of upregulated QC resulting in disease manifestation are reviewed, along with progress on the development of QC inhibitors." @default.
- W3160110271 created "2021-05-24" @default.
- W3160110271 creator A5047080898 @default.
- W3160110271 creator A5068949602 @default.
- W3160110271 creator A5085490427 @default.
- W3160110271 date "2021-05-18" @default.
- W3160110271 modified "2023-09-25" @default.
- W3160110271 title "Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors" @default.
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