FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160147150> ?p ?o ?g. }

• W3160147150 endingPage "341" @default.
• W3160147150 startingPage "334" @default.
• W3160147150 abstract "Background Atopic dermatitis (AD) is a common disease, with particularly high prevalence found in Africa. It is increasingly recognized that patients with AD of different ethnic backgrounds have unique molecular signatures in the skin, potentially accounting for treatment response variations. Nevertheless, the skin profile of patients with AD from Africa is unknown, hindering development of new treatments targeted to this patient population. Objective To characterize the skin profile of patients with AD from Africa. Methods Gene expression studies, including RNA sequencing (using threshold of fold change of >2 and false discovery rate of <0.05) and real-time polymerase chain reaction, were performed on skin biopsies of Tanzanian patients with moderate-to-severe AD and controls. Results Tanzanian AD skin presented robust up-regulations of multiple key mediators of both T helper 2 (TH2) (interleukin 13 [IL-13], IL-10, IL-4R, CCL13,CCL17,CCL18,CCL26) and TH22 (IL22, S100As) pathways. Markers related to TH17 and IL-23 (IL-17A, IL-23A, IL-12, PI3, DEFB4B) and TH1 (interferon gamma, CXCL9,CXCL10,CXCL11) were also significantly overexpressed in AD tissues (FDR<.05), albeit to a lesser extent. IL-36 isoforms revealed substantial up-regulations in African skin. The barrier fingerprint of Tanzanian AD revealed no suppression of hallmark epidermal barrier differentiation genes, such as filaggrin, loricrin, and periplakin, with robust attenuation of lipid metabolism genes (ie, AWAT1). Conclusion The skin phenotype of Tanzanian patients with AD is consistent with that of African Americans, exhibiting dominant TH2 and TH22 skewing, minimal dysregulation of terminal differentiation, and even broader attenuation of lipid metabolism-related products. These data highlight the unique characteristic of AD in Black individuals and the need to develop unique treatments targeting patients with AD from these underrepresented populations." @default.
• W3160147150 created "2021-05-24" @default.
• W3160147150 creator A5000310313 @default.
• W3160147150 creator A5003529451 @default.
• W3160147150 creator A5007511217 @default.
• W3160147150 creator A5008637093 @default.
• W3160147150 creator A5016998382 @default.
• W3160147150 creator A5018491769 @default.
• W3160147150 creator A5024071364 @default.
• W3160147150 creator A5024365532 @default.
• W3160147150 creator A5032965176 @default.
• W3160147150 creator A5035849206 @default.
• W3160147150 creator A5040566072 @default.
• W3160147150 creator A5044954717 @default.
• W3160147150 creator A5049320628 @default.
• W3160147150 creator A5054418515 @default.
• W3160147150 creator A5057248346 @default.
• W3160147150 creator A5069941408 @default.
• W3160147150 creator A5080337749 @default.
• W3160147150 creator A5091528125 @default.
• W3160147150 date "2021-09-01" @default.
• W3160147150 modified "2023-10-13" @default.
• W3160147150 title "Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients" @default.
• W3160147150 cites W1485278347 @default.
• W3160147150 cites W1504410502 @default.
• W3160147150 cites W1575716415 @default.
• W3160147150 cites W1580600982 @default.
• W3160147150 cites W1965007203 @default.
• W3160147150 cites W1965139821 @default.
• W3160147150 cites W1971402668 @default.
• W3160147150 cites W1974004014 @default.
• W3160147150 cites W1975831236 @default.
• W3160147150 cites W1984314853 @default.
• W3160147150 cites W1994303190 @default.
• W3160147150 cites W1995723686 @default.
• W3160147150 cites W1999975793 @default.
• W3160147150 cites W2028971352 @default.
• W3160147150 cites W2032896969 @default.
• W3160147150 cites W2039557605 @default.
• W3160147150 cites W2051864455 @default.
• W3160147150 cites W2051902015 @default.
• W3160147150 cites W2057098942 @default.
• W3160147150 cites W2063748338 @default.
• W3160147150 cites W2067791830 @default.
• W3160147150 cites W2068259827 @default.
• W3160147150 cites W2069364241 @default.
• W3160147150 cites W2092750645 @default.
• W3160147150 cites W2103825953 @default.
• W3160147150 cites W2106136941 @default.
• W3160147150 cites W2106551918 @default.
• W3160147150 cites W2109151819 @default.
• W3160147150 cites W2129316818 @default.
• W3160147150 cites W2139970893 @default.
• W3160147150 cites W2147754730 @default.
• W3160147150 cites W2153422316 @default.
• W3160147150 cites W2156992552 @default.
• W3160147150 cites W2169114803 @default.
• W3160147150 cites W2199733448 @default.
• W3160147150 cites W2411361269 @default.
• W3160147150 cites W2510730292 @default.
• W3160147150 cites W2516648212 @default.
• W3160147150 cites W2576224466 @default.
• W3160147150 cites W2592308442 @default.
• W3160147150 cites W2616674796 @default.
• W3160147150 cites W2767616012 @default.
• W3160147150 cites W2785046802 @default.
• W3160147150 cites W2785622949 @default.
• W3160147150 cites W2793626841 @default.
• W3160147150 cites W2797136473 @default.
• W3160147150 cites W2809858936 @default.
• W3160147150 cites W2810820884 @default.
• W3160147150 cites W2891440616 @default.
• W3160147150 cites W2892288216 @default.
• W3160147150 cites W2900959710 @default.
• W3160147150 cites W2907756900 @default.
• W3160147150 cites W2912302727 @default.
• W3160147150 cites W2914866862 @default.
• W3160147150 cites W2980019105 @default.
• W3160147150 cites W2985387441 @default.
• W3160147150 cites W3044679662 @default.
• W3160147150 cites W3046068546 @default.
• W3160147150 cites W3048969568 @default.
• W3160147150 cites W3124533285 @default.
• W3160147150 cites W4211145137 @default.
• W3160147150 cites W4244585549 @default.
• W3160147150 doi "https://doi.org/10.1016/j.anai.2021.04.023" @default.
• W3160147150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33975024" @default.
• W3160147150 hasPublicationYear "2021" @default.
• W3160147150 type Work @default.
• W3160147150 sameAs 3160147150 @default.
• W3160147150 citedByCount "16" @default.
• W3160147150 countsByYear W31601471502021 @default.
• W3160147150 countsByYear W31601471502022 @default.
• W3160147150 countsByYear W31601471502023 @default.
• W3160147150 crossrefType "journal-article" @default.
• W3160147150 hasAuthorship W3160147150A5000310313 @default.
• W3160147150 hasAuthorship W3160147150A5003529451 @default.
• W3160147150 hasAuthorship W3160147150A5007511217 @default.

• next