Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160147797> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3160147797 abstract "Introduction :The use of broad-spectrum antibiotics, including an anti-anaerobic spectrum, is associated with the emergence of multi-resistant bacteria. However, all the new molecules on the market targeting GNB are very broad-spectrum, implying a strong ecological impact. Particularly in resuscitation, the volume of antibiotic prescriptions is very high. It is necessary to limit the pressure of antibiotic selection by using molecules with a narrower spectrum and less ecological impact. We propose to use in the existing pharmacopoeia the narrow spectrum molecules whose optmisation of PK/PD parameters would allow them to be used as an alternative to Carbapenems, third and fourth generation Cephalosporins or fluroquinolones.Methods :Systematic review of the literature allowing in a first step to select antibiotics active against GNB with a low ecological impact. In a second step, a literature review will allow to define the modalities of use of the selected molecules for the optimization of the PK/PD parameters integrating dosage, stability data and infusion modalities.Results and Discussion :Cefoxitin, temocillin, Amoxicillin ac clavulanic, aztreonam, piperacillin, piperacillin tazobactam, cotrimoxazole were selected for their lower ecological impact and their possible integration in an antibiotic stewardship program in intensive care. We propose continuous infusion administration methods to optimize the PK/PD parameters of its time-dependent molecules at maximum doses. Under the conditions of use in intensive care, the stability data allow the use of electric syringes for the infusion of temocillin, aztreonam and cefoxitin, the other molecules will have to be used with a volumetric pump.Conclusions :An antibiotic stewardship policy in resuscitation can integrate alternatives to molecules with high ecological impact with the use of Cefoxitin, temocillin, piperacillin, aztreonam and cotrimoxazole in continuous infusion using electric syringes or volumetric pumps." @default.
- W3160147797 created "2021-05-24" @default.
- W3160147797 creator A5030637372 @default.
- W3160147797 creator A5051536421 @default.
- W3160147797 creator A5056140361 @default.
- W3160147797 creator A5058528296 @default.
- W3160147797 creator A5060367774 @default.
- W3160147797 creator A5067979246 @default.
- W3160147797 creator A5072458877 @default.
- W3160147797 creator A5077295930 @default.
- W3160147797 creator A5082424239 @default.
- W3160147797 date "2021-05-10" @default.
- W3160147797 modified "2023-09-27" @default.
- W3160147797 title "Old antibitiotics, new solutions: old narrow spectrum betalactamine and cotrimoxazole with PK/PD optimization as a treatment for gram negative bacteria in ICU" @default.
- W3160147797 hasPublicationYear "2021" @default.
- W3160147797 type Work @default.
- W3160147797 sameAs 3160147797 @default.
- W3160147797 citedByCount "0" @default.
- W3160147797 crossrefType "journal-article" @default.
- W3160147797 hasAuthorship W3160147797A5030637372 @default.
- W3160147797 hasAuthorship W3160147797A5051536421 @default.
- W3160147797 hasAuthorship W3160147797A5056140361 @default.
- W3160147797 hasAuthorship W3160147797A5058528296 @default.
- W3160147797 hasAuthorship W3160147797A5060367774 @default.
- W3160147797 hasAuthorship W3160147797A5067979246 @default.
- W3160147797 hasAuthorship W3160147797A5072458877 @default.
- W3160147797 hasAuthorship W3160147797A5077295930 @default.
- W3160147797 hasAuthorship W3160147797A5082424239 @default.
- W3160147797 hasConcept C177713679 @default.
- W3160147797 hasConcept C2776040555 @default.
- W3160147797 hasConcept C2776124114 @default.
- W3160147797 hasConcept C2776685102 @default.
- W3160147797 hasConcept C2777637488 @default.
- W3160147797 hasConcept C2778193466 @default.
- W3160147797 hasConcept C2778266534 @default.
- W3160147797 hasConcept C2779489039 @default.
- W3160147797 hasConcept C2779631663 @default.
- W3160147797 hasConcept C2780416669 @default.
- W3160147797 hasConcept C2987404301 @default.
- W3160147797 hasConcept C501593827 @default.
- W3160147797 hasConcept C523546767 @default.
- W3160147797 hasConcept C54355233 @default.
- W3160147797 hasConcept C71924100 @default.
- W3160147797 hasConcept C86803240 @default.
- W3160147797 hasConcept C89423630 @default.
- W3160147797 hasConcept C94665300 @default.
- W3160147797 hasConceptScore W3160147797C177713679 @default.
- W3160147797 hasConceptScore W3160147797C2776040555 @default.
- W3160147797 hasConceptScore W3160147797C2776124114 @default.
- W3160147797 hasConceptScore W3160147797C2776685102 @default.
- W3160147797 hasConceptScore W3160147797C2777637488 @default.
- W3160147797 hasConceptScore W3160147797C2778193466 @default.
- W3160147797 hasConceptScore W3160147797C2778266534 @default.
- W3160147797 hasConceptScore W3160147797C2779489039 @default.
- W3160147797 hasConceptScore W3160147797C2779631663 @default.
- W3160147797 hasConceptScore W3160147797C2780416669 @default.
- W3160147797 hasConceptScore W3160147797C2987404301 @default.
- W3160147797 hasConceptScore W3160147797C501593827 @default.
- W3160147797 hasConceptScore W3160147797C523546767 @default.
- W3160147797 hasConceptScore W3160147797C54355233 @default.
- W3160147797 hasConceptScore W3160147797C71924100 @default.
- W3160147797 hasConceptScore W3160147797C86803240 @default.
- W3160147797 hasConceptScore W3160147797C89423630 @default.
- W3160147797 hasConceptScore W3160147797C94665300 @default.
- W3160147797 hasLocation W31601477971 @default.
- W3160147797 hasOpenAccess W3160147797 @default.
- W3160147797 hasPrimaryLocation W31601477971 @default.
- W3160147797 hasRelatedWork W136720919 @default.
- W3160147797 hasRelatedWork W1957731371 @default.
- W3160147797 hasRelatedWork W1966148145 @default.
- W3160147797 hasRelatedWork W1969586568 @default.
- W3160147797 hasRelatedWork W1972682777 @default.
- W3160147797 hasRelatedWork W2030145210 @default.
- W3160147797 hasRelatedWork W2041785945 @default.
- W3160147797 hasRelatedWork W2042977018 @default.
- W3160147797 hasRelatedWork W2124942073 @default.
- W3160147797 hasRelatedWork W2150880328 @default.
- W3160147797 hasRelatedWork W2527983258 @default.
- W3160147797 hasRelatedWork W2796247249 @default.
- W3160147797 hasRelatedWork W2976495713 @default.
- W3160147797 hasRelatedWork W3005362484 @default.
- W3160147797 hasRelatedWork W3092391711 @default.
- W3160147797 hasRelatedWork W3092465192 @default.
- W3160147797 hasRelatedWork W3111523144 @default.
- W3160147797 hasRelatedWork W3120177289 @default.
- W3160147797 hasRelatedWork W31212056 @default.
- W3160147797 hasRelatedWork W3203181037 @default.
- W3160147797 isParatext "false" @default.
- W3160147797 isRetracted "false" @default.
- W3160147797 magId "3160147797" @default.
- W3160147797 workType "article" @default.