FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160240799> ?p ?o ?g. }

• W3160240799 abstract "Abstract Background Old age, the most important risk factor for Alzheimer’s disease (AD), is associated with thermoregulatory deficits. Brown adipose tissue (BAT) is the main thermogenic driver in mammals and its stimulation, through β3 adrenergic receptor (β3AR) agonists or cold acclimation, counteracts metabolic deficits in rodents and humans. Studies in animal models show that AD neuropathology leads to thermoregulatory deficits, and cold-induced tau hyperphosphorylation is prevented by BAT stimulation through cold acclimation. Since metabolic disorders and AD share strong pathogenic links, we hypothesized that BAT stimulation through a β3AR agonist could exert benefits in AD as well. Methods CL-316,243, a specific β3AR agonist, was administered to the triple transgenic mouse model of AD (3xTg-AD) and non-transgenic controls from 15 to 16 months of age at a dose of 1 mg/kg/day i.p. Results Here, we show that β3AR agonist administration decreased body weight and improved peripheral glucose metabolism and BAT thermogenesis in both non-transgenic and 3xTg-AD mice. One-month treatment with a β3AR agonist increased recognition index by 19% in 16-month-old 3xTg-AD mice compared to pre-treatment (14-month-old). Locomotion, anxiety, and tau pathology were not modified. Finally, insoluble Aβ42/Aβ40 ratio was decreased by 27% in the hippocampus of CL-316,243-injected 3xTg-AD mice. Conclusions Overall, our results indicate that β3AR stimulation reverses memory deficits and shifts downward the insoluble Aβ42/Aβ40 ratio in 16-month-old 3xTg-AD mice. As β3AR agonists are being clinically developed for metabolic disorders, repurposing them in AD could be a valuable therapeutic strategy." @default.
• W3160240799 created "2021-05-24" @default.
• W3160240799 creator A5005670129 @default.
• W3160240799 creator A5011526572 @default.
• W3160240799 creator A5015008436 @default.
• W3160240799 creator A5022727147 @default.
• W3160240799 creator A5026717739 @default.
• W3160240799 creator A5062385111 @default.
• W3160240799 creator A5063485120 @default.
• W3160240799 creator A5067147788 @default.
• W3160240799 creator A5088549256 @default.
• W3160240799 date "2021-05-21" @default.
• W3160240799 modified "2023-10-17" @default.
• W3160240799 title "Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model" @default.
• W3160240799 cites W1127264686 @default.
• W3160240799 cites W1534788982 @default.
• W3160240799 cites W1578509843 @default.
• W3160240799 cites W1592268161 @default.
• W3160240799 cites W1787320721 @default.
• W3160240799 cites W1936929000 @default.
• W3160240799 cites W1963721982 @default.
• W3160240799 cites W1965079305 @default.
• W3160240799 cites W1966681419 @default.
• W3160240799 cites W1967464880 @default.
• W3160240799 cites W1968509617 @default.
• W3160240799 cites W1971599675 @default.
• W3160240799 cites W1973192205 @default.
• W3160240799 cites W1973802652 @default.
• W3160240799 cites W1975134899 @default.
• W3160240799 cites W1990449902 @default.
• W3160240799 cites W1998860843 @default.
• W3160240799 cites W2001746866 @default.
• W3160240799 cites W2002306490 @default.
• W3160240799 cites W2003966687 @default.
• W3160240799 cites W2006081805 @default.
• W3160240799 cites W2010240177 @default.
• W3160240799 cites W2011829284 @default.
• W3160240799 cites W2017443057 @default.
• W3160240799 cites W2019100110 @default.
• W3160240799 cites W2021985872 @default.
• W3160240799 cites W2022178570 @default.
• W3160240799 cites W2025987208 @default.
• W3160240799 cites W2028384515 @default.
• W3160240799 cites W2029492339 @default.
• W3160240799 cites W2031745631 @default.
• W3160240799 cites W2032885546 @default.
• W3160240799 cites W2039140744 @default.
• W3160240799 cites W2040328785 @default.
• W3160240799 cites W2044828679 @default.
• W3160240799 cites W2046053621 @default.
• W3160240799 cites W2057420463 @default.
• W3160240799 cites W2069183695 @default.
• W3160240799 cites W2071068165 @default.
• W3160240799 cites W2071305328 @default.
• W3160240799 cites W2071895132 @default.
• W3160240799 cites W2073252618 @default.
• W3160240799 cites W2075282827 @default.
• W3160240799 cites W2076517751 @default.
• W3160240799 cites W2077859404 @default.
• W3160240799 cites W2083254102 @default.
• W3160240799 cites W2089189236 @default.
• W3160240799 cites W2089730073 @default.
• W3160240799 cites W2090592868 @default.
• W3160240799 cites W2091910339 @default.
• W3160240799 cites W2094113864 @default.
• W3160240799 cites W2094778473 @default.
• W3160240799 cites W2096405787 @default.
• W3160240799 cites W2102528806 @default.
• W3160240799 cites W2106821430 @default.
• W3160240799 cites W2109273797 @default.
• W3160240799 cites W2116508134 @default.
• W3160240799 cites W2119324011 @default.
• W3160240799 cites W2119649463 @default.
• W3160240799 cites W2124279119 @default.
• W3160240799 cites W2126496247 @default.
• W3160240799 cites W2131116946 @default.
• W3160240799 cites W2131762758 @default.
• W3160240799 cites W2132358997 @default.
• W3160240799 cites W2134380477 @default.
• W3160240799 cites W2136901555 @default.
• W3160240799 cites W2147435466 @default.
• W3160240799 cites W2153284686 @default.
• W3160240799 cites W2157215579 @default.
• W3160240799 cites W2158226583 @default.
• W3160240799 cites W2158381042 @default.
• W3160240799 cites W2164410780 @default.
• W3160240799 cites W2189621653 @default.
• W3160240799 cites W2198455611 @default.
• W3160240799 cites W2298887234 @default.
• W3160240799 cites W2324851902 @default.
• W3160240799 cites W2329336071 @default.
• W3160240799 cites W2346315565 @default.
• W3160240799 cites W2426168356 @default.
• W3160240799 cites W2509020311 @default.
• W3160240799 cites W2513724444 @default.
• W3160240799 cites W2521606612 @default.
• W3160240799 cites W2524615830 @default.
• W3160240799 cites W2530884864 @default.
• W3160240799 cites W2564388384 @default.
• W3160240799 cites W2580891776 @default.

• next