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• W3160294837 endingPage "118214" @default.
• W3160294837 startingPage "118214" @default.
• W3160294837 abstract "Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. SHPS-1 consisted of arabinose, mannose, glucose, and galactose at a molar ratio of 2.2:15.7:49.3:32.8. SHPS-1 had a backbone containing 1,3-linked β-D-Glcp and 1,6-linked α-D-Galp residues, and Araf, Manp and Galp units were attached as oligosaccharidic side chains to the backbone at C-6 of some glucopyranoses. SHPS-1 decreased phosphorylation level of STAT-1 and expression levels of STAT-1 targeted genes such as iNOS and TNF-α in lipopolysaccharide-stimulated macrophage RAW 264.7 cells. Furthermore, SHPS-1 promoted the expression of IL-10 and macrophage mannose receptor CD 206, markers of tissue repairing macrophages. SHPS-1 alleviated ulcerative colitis in mice by decreasing pro-inflammatory genes and increasing anti-inflammatory and tissue repairing genes. Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD." @default.
• W3160294837 created "2021-05-24" @default.
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• W3160294837 date "2021-09-01" @default.
• W3160294837 modified "2023-10-12" @default.
• W3160294837 title "Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii" @default.
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• W3160294837 doi "https://doi.org/10.1016/j.carbpol.2021.118214" @default.
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