Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160381330> ?p ?o ?g. }
- W3160381330 abstract "Abstract High-yielding and selective prebiotic syntheses of RNA and DNA nucleotides involve UV irradiation to promote the key reaction steps and eradicate biologically irrelevant isomers. While these syntheses were likely enabled by UV-rich prebiotic environment, UV-induced formation of photodamages in polymeric nucleic acids, such as cyclobutane pyrimidine dimers (CPDs), remains the key unresolved issue for the origins of RNA and DNA on Earth. Here, we demonstrate that substitution of adenine with 2,6-diaminopurine enables repair of CPDs with yields reaching 92%. This substantial self-repairing activity originates from excellent electron donating properties of 2,6-diaminopurine in nucleic acid strands. We also show that the deoxyribonucleosides of 2,6-diaminopurine and adenine can be formed under the same prebiotic conditions. Considering that 2,6-diaminopurine was previously shown to increase the rate of nonenzymatic RNA replication, this nucleobase could have played critical roles in the formation of functional and photostable RNA/DNA oligomers in UV-rich prebiotic environments." @default.
- W3160381330 created "2021-05-24" @default.
- W3160381330 creator A5011223466 @default.
- W3160381330 creator A5026399646 @default.
- W3160381330 creator A5028117879 @default.
- W3160381330 creator A5028187203 @default.
- W3160381330 creator A5058691299 @default.
- W3160381330 creator A5070452050 @default.
- W3160381330 creator A5081739798 @default.
- W3160381330 creator A5081941584 @default.
- W3160381330 date "2021-05-21" @default.
- W3160381330 modified "2023-10-16" @default.
- W3160381330 title "2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions" @default.
- W3160381330 cites W1534726296 @default.
- W3160381330 cites W1969189143 @default.
- W3160381330 cites W1970996037 @default.
- W3160381330 cites W1975968626 @default.
- W3160381330 cites W1976224714 @default.
- W3160381330 cites W1979426988 @default.
- W3160381330 cites W1981225934 @default.
- W3160381330 cites W1987397407 @default.
- W3160381330 cites W1990345925 @default.
- W3160381330 cites W1990656149 @default.
- W3160381330 cites W1998267570 @default.
- W3160381330 cites W2002299165 @default.
- W3160381330 cites W2003112431 @default.
- W3160381330 cites W2008349049 @default.
- W3160381330 cites W2010790220 @default.
- W3160381330 cites W2012669304 @default.
- W3160381330 cites W2013673362 @default.
- W3160381330 cites W2020678264 @default.
- W3160381330 cites W2026829672 @default.
- W3160381330 cites W2028022118 @default.
- W3160381330 cites W2028770952 @default.
- W3160381330 cites W2035266068 @default.
- W3160381330 cites W2037547893 @default.
- W3160381330 cites W2046585998 @default.
- W3160381330 cites W2049475242 @default.
- W3160381330 cites W2053586924 @default.
- W3160381330 cites W2056152537 @default.
- W3160381330 cites W2059742271 @default.
- W3160381330 cites W2064256726 @default.
- W3160381330 cites W2064659067 @default.
- W3160381330 cites W2066421562 @default.
- W3160381330 cites W2066690664 @default.
- W3160381330 cites W2082168427 @default.
- W3160381330 cites W2086735239 @default.
- W3160381330 cites W2087304588 @default.
- W3160381330 cites W2087406053 @default.
- W3160381330 cites W2089644153 @default.
- W3160381330 cites W2089715338 @default.
- W3160381330 cites W2093535350 @default.
- W3160381330 cites W2103945336 @default.
- W3160381330 cites W2106140689 @default.
- W3160381330 cites W2122199548 @default.
- W3160381330 cites W2124357718 @default.
- W3160381330 cites W2135676218 @default.
- W3160381330 cites W2136729627 @default.
- W3160381330 cites W2152620792 @default.
- W3160381330 cites W2165835468 @default.
- W3160381330 cites W2169858698 @default.
- W3160381330 cites W2233106825 @default.
- W3160381330 cites W2257280499 @default.
- W3160381330 cites W2277335037 @default.
- W3160381330 cites W2281395179 @default.
- W3160381330 cites W2314493427 @default.
- W3160381330 cites W2344252179 @default.
- W3160381330 cites W23781914 @default.
- W3160381330 cites W2386517417 @default.
- W3160381330 cites W2419067302 @default.
- W3160381330 cites W2514595599 @default.
- W3160381330 cites W2524907703 @default.
- W3160381330 cites W2526737712 @default.
- W3160381330 cites W2554800362 @default.
- W3160381330 cites W2763165835 @default.
- W3160381330 cites W2766112608 @default.
- W3160381330 cites W2789136273 @default.
- W3160381330 cites W2893486873 @default.
- W3160381330 cites W2897102694 @default.
- W3160381330 cites W2902064723 @default.
- W3160381330 cites W2903417601 @default.
- W3160381330 cites W2933437492 @default.
- W3160381330 cites W2947834151 @default.
- W3160381330 cites W2953100445 @default.
- W3160381330 cites W2978780344 @default.
- W3160381330 cites W3000568981 @default.
- W3160381330 cites W3026599087 @default.
- W3160381330 cites W3029443600 @default.
- W3160381330 cites W3093824239 @default.
- W3160381330 cites W3104468196 @default.
- W3160381330 cites W3113015795 @default.
- W3160381330 doi "https://doi.org/10.1038/s41467-021-23300-y" @default.
- W3160381330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8139960" @default.
- W3160381330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34021158" @default.
- W3160381330 hasPublicationYear "2021" @default.
- W3160381330 type Work @default.
- W3160381330 sameAs 3160381330 @default.
- W3160381330 citedByCount "16" @default.
- W3160381330 countsByYear W31603813302021 @default.
- W3160381330 countsByYear W31603813302022 @default.