FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160387629> ?p ?o ?g. }

• W3160387629 endingPage "38" @default.
• W3160387629 startingPage "31" @default.
• W3160387629 abstract "Abstract Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability. Therapeutic hypothermia (TH) is the only available standard of treatment, but 45–55% of cases still result in death or neurodevelopmental disability following TH. This work has focussed on developing a new brain tissue physiology and biochemistry systems biology model that includes temperature effects, as well as a Bayesian framework for analysis of model parameter estimation. Through this, we can simulate the effects of temperature on brain tissue oxygen delivery and metabolism, as well as analyse clinical and experimental data to identify mechanisms to explain differing behaviour and outcome. Presented here is an application of the model to data from two piglets treated with TH following hypoxic-ischaemic injury showing different responses and outcome following treatment. We identify the main mechanism for this difference as the Q 10 temperature coefficient for metabolic reactions, with the severely injured piglet having a median posterior value of 0.133 as opposed to the mild injury value of 5.48. This work demonstrates the use of systems biology models to investigate underlying mechanisms behind the varying response to hypothermic treatment." @default.
• W3160387629 created "2021-05-24" @default.
• W3160387629 creator A5002232290 @default.
• W3160387629 creator A5011939186 @default.
• W3160387629 creator A5014884779 @default.
• W3160387629 creator A5020983079 @default.
• W3160387629 creator A5034601082 @default.
• W3160387629 creator A5043856880 @default.
• W3160387629 creator A5059002450 @default.
• W3160387629 creator A5068293187 @default.
• W3160387629 creator A5070186324 @default.
• W3160387629 creator A5082354615 @default.
• W3160387629 creator A5085406999 @default.
• W3160387629 creator A5087206127 @default.
• W3160387629 date "2021-01-01" @default.
• W3160387629 modified "2023-09-24" @default.
• W3160387629 title "Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model" @default.
• W3160387629 cites W1979728048 @default.
• W3160387629 cites W2065546850 @default.
• W3160387629 cites W2070937027 @default.
• W3160387629 cites W2076363037 @default.
• W3160387629 cites W2082138205 @default.
• W3160387629 cites W2112688865 @default.
• W3160387629 cites W2135122869 @default.
• W3160387629 cites W2149152815 @default.
• W3160387629 cites W2217900354 @default.
• W3160387629 cites W2342273668 @default.
• W3160387629 cites W2513548613 @default.
• W3160387629 cites W2803488946 @default.
• W3160387629 cites W2950122445 @default.
• W3160387629 cites W2989275612 @default.
• W3160387629 cites W2998392299 @default.
• W3160387629 cites W332478907 @default.
• W3160387629 doi "https://doi.org/10.1007/978-3-030-48238-1_5" @default.
• W3160387629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33966191" @default.
• W3160387629 hasPublicationYear "2021" @default.
• W3160387629 type Work @default.
• W3160387629 sameAs 3160387629 @default.
• W3160387629 citedByCount "1" @default.
• W3160387629 countsByYear W31603876292022 @default.
• W3160387629 crossrefType "book-chapter" @default.
• W3160387629 hasAuthorship W3160387629A5002232290 @default.
• W3160387629 hasAuthorship W3160387629A5011939186 @default.
• W3160387629 hasAuthorship W3160387629A5014884779 @default.
• W3160387629 hasAuthorship W3160387629A5020983079 @default.
• W3160387629 hasAuthorship W3160387629A5034601082 @default.
• W3160387629 hasAuthorship W3160387629A5043856880 @default.
• W3160387629 hasAuthorship W3160387629A5059002450 @default.
• W3160387629 hasAuthorship W3160387629A5068293187 @default.
• W3160387629 hasAuthorship W3160387629A5070186324 @default.
• W3160387629 hasAuthorship W3160387629A5082354615 @default.
• W3160387629 hasAuthorship W3160387629A5085406999 @default.
• W3160387629 hasAuthorship W3160387629A5087206127 @default.
• W3160387629 hasBestOaLocation W31603876291 @default.
• W3160387629 hasConcept C111472728 @default.
• W3160387629 hasConcept C126322002 @default.
• W3160387629 hasConcept C138885662 @default.
• W3160387629 hasConcept C169760540 @default.
• W3160387629 hasConcept C177713679 @default.
• W3160387629 hasConcept C2777390192 @default.
• W3160387629 hasConcept C2778621155 @default.
• W3160387629 hasConcept C42219234 @default.
• W3160387629 hasConcept C42407357 @default.
• W3160387629 hasConcept C60644358 @default.
• W3160387629 hasConcept C71924100 @default.
• W3160387629 hasConcept C86803240 @default.
• W3160387629 hasConcept C89611455 @default.
• W3160387629 hasConceptScore W3160387629C111472728 @default.
• W3160387629 hasConceptScore W3160387629C126322002 @default.
• W3160387629 hasConceptScore W3160387629C138885662 @default.
• W3160387629 hasConceptScore W3160387629C169760540 @default.
• W3160387629 hasConceptScore W3160387629C177713679 @default.
• W3160387629 hasConceptScore W3160387629C2777390192 @default.
• W3160387629 hasConceptScore W3160387629C2778621155 @default.
• W3160387629 hasConceptScore W3160387629C42219234 @default.
• W3160387629 hasConceptScore W3160387629C42407357 @default.
• W3160387629 hasConceptScore W3160387629C60644358 @default.
• W3160387629 hasConceptScore W3160387629C71924100 @default.
• W3160387629 hasConceptScore W3160387629C86803240 @default.
• W3160387629 hasConceptScore W3160387629C89611455 @default.
• W3160387629 hasLocation W31603876291 @default.
• W3160387629 hasLocation W31603876292 @default.
• W3160387629 hasLocation W31603876293 @default.
• W3160387629 hasLocation W31603876294 @default.
• W3160387629 hasOpenAccess W3160387629 @default.
• W3160387629 hasPrimaryLocation W31603876291 @default.
• W3160387629 hasRelatedWork W2000060824 @default.
• W3160387629 hasRelatedWork W2007451860 @default.
• W3160387629 hasRelatedWork W2010895499 @default.
• W3160387629 hasRelatedWork W2058023068 @default.
• W3160387629 hasRelatedWork W2083515790 @default.
• W3160387629 hasRelatedWork W2149308196 @default.
• W3160387629 hasRelatedWork W2466180888 @default.
• W3160387629 hasRelatedWork W2549135832 @default.
• W3160387629 hasRelatedWork W2569615598 @default.
• W3160387629 hasRelatedWork W2883492499 @default.
• W3160387629 isParatext "false" @default.
• W3160387629 isRetracted "false" @default.

• next