Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160388166> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3160388166 abstract "Glioblastoma multiforme (GBM) is a lethal primary brain tumor with poor survival lifespan and dismal outcome. However, the effects and mechanisms of epigenetic factors on the development of GBM were still not well illustrated. We found that expression of enhancer of zeste homolog 2 (EZH2), which can catalyze histone H3K27me3 to modulate gene expression, was increased in GBM cells. Knockdown of EZH2 can suppress proliferation and migration, while increase temozolomide (TMZ) sensitivity, of GBM cells. Further, knockdown of EZH2 or its specific inhibitor GSK126 can decrease expression of Twist, while over expression of Twist can reverse si-EZH2-suppressed malignancy of GBM cells. Mechanistically, EZH2 can positively regulate mRNA stability of Twist1 mRNA. Further, miR-206, which can bind with 3'UTR of Twist1 mRNA, was involved in EZH2-regulated mRNA stability of Twist1. Collectively, our data suggest that EZH2 might be a potential target for GBM treatment. Further, miR-206/Twist axis is involved in EZH2-regulated malignancy of GBM cells." @default.
- W3160388166 created "2021-05-24" @default.
- W3160388166 creator A5011090841 @default.
- W3160388166 creator A5027699997 @default.
- W3160388166 creator A5035267870 @default.
- W3160388166 creator A5055046208 @default.
- W3160388166 creator A5056344408 @default.
- W3160388166 creator A5067888944 @default.
- W3160388166 creator A5088035299 @default.
- W3160388166 date "2021-08-05" @default.
- W3160388166 modified "2023-09-26" @default.
- W3160388166 title "EZH2 regulates the malignancy of human glioblastoma cells via modulation of Twist mRNA stability." @default.
- W3160388166 cites W1775309324 @default.
- W3160388166 cites W1969485334 @default.
- W3160388166 cites W1995652309 @default.
- W3160388166 cites W1996487270 @default.
- W3160388166 cites W2033987226 @default.
- W3160388166 cites W2111737333 @default.
- W3160388166 cites W2141349487 @default.
- W3160388166 cites W2171439874 @default.
- W3160388166 cites W2258531487 @default.
- W3160388166 cites W2573214723 @default.
- W3160388166 cites W2606792465 @default.
- W3160388166 cites W2733398634 @default.
- W3160388166 cites W2756777461 @default.
- W3160388166 cites W2769376917 @default.
- W3160388166 cites W2784093632 @default.
- W3160388166 cites W2800037441 @default.
- W3160388166 cites W2802299363 @default.
- W3160388166 cites W2911341716 @default.
- W3160388166 cites W2994331330 @default.
- W3160388166 cites W3016840787 @default.
- W3160388166 cites W3045753156 @default.
- W3160388166 cites W3111361128 @default.
- W3160388166 cites W327384751 @default.
- W3160388166 cites W4211132876 @default.
- W3160388166 doi "https://doi.org/10.1016/j.ejphar.2021.174177" @default.
- W3160388166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34015321" @default.
- W3160388166 hasPublicationYear "2021" @default.
- W3160388166 type Work @default.
- W3160388166 sameAs 3160388166 @default.
- W3160388166 citedByCount "4" @default.
- W3160388166 countsByYear W31603881662022 @default.
- W3160388166 countsByYear W31603881662023 @default.
- W3160388166 crossrefType "journal-article" @default.
- W3160388166 hasAuthorship W3160388166A5011090841 @default.
- W3160388166 hasAuthorship W3160388166A5027699997 @default.
- W3160388166 hasAuthorship W3160388166A5035267870 @default.
- W3160388166 hasAuthorship W3160388166A5055046208 @default.
- W3160388166 hasAuthorship W3160388166A5056344408 @default.
- W3160388166 hasAuthorship W3160388166A5067888944 @default.
- W3160388166 hasAuthorship W3160388166A5088035299 @default.
- W3160388166 hasConcept C104317684 @default.
- W3160388166 hasConcept C105580179 @default.
- W3160388166 hasConcept C150425827 @default.
- W3160388166 hasConcept C173396325 @default.
- W3160388166 hasConcept C2776194525 @default.
- W3160388166 hasConcept C2777389519 @default.
- W3160388166 hasConcept C2779399171 @default.
- W3160388166 hasConcept C41091548 @default.
- W3160388166 hasConcept C50171091 @default.
- W3160388166 hasConcept C502942594 @default.
- W3160388166 hasConcept C54355233 @default.
- W3160388166 hasConcept C81885089 @default.
- W3160388166 hasConcept C86803240 @default.
- W3160388166 hasConceptScore W3160388166C104317684 @default.
- W3160388166 hasConceptScore W3160388166C105580179 @default.
- W3160388166 hasConceptScore W3160388166C150425827 @default.
- W3160388166 hasConceptScore W3160388166C173396325 @default.
- W3160388166 hasConceptScore W3160388166C2776194525 @default.
- W3160388166 hasConceptScore W3160388166C2777389519 @default.
- W3160388166 hasConceptScore W3160388166C2779399171 @default.
- W3160388166 hasConceptScore W3160388166C41091548 @default.
- W3160388166 hasConceptScore W3160388166C50171091 @default.
- W3160388166 hasConceptScore W3160388166C502942594 @default.
- W3160388166 hasConceptScore W3160388166C54355233 @default.
- W3160388166 hasConceptScore W3160388166C81885089 @default.
- W3160388166 hasConceptScore W3160388166C86803240 @default.
- W3160388166 hasFunder F4320327720 @default.
- W3160388166 hasLocation W31603881661 @default.
- W3160388166 hasLocation W31603881662 @default.
- W3160388166 hasOpenAccess W3160388166 @default.
- W3160388166 hasPrimaryLocation W31603881661 @default.
- W3160388166 hasRelatedWork W1549366169 @default.
- W3160388166 hasRelatedWork W2024344351 @default.
- W3160388166 hasRelatedWork W2040830156 @default.
- W3160388166 hasRelatedWork W2291093385 @default.
- W3160388166 hasRelatedWork W2790697745 @default.
- W3160388166 hasRelatedWork W3157541268 @default.
- W3160388166 hasRelatedWork W3160388166 @default.
- W3160388166 hasRelatedWork W3197962175 @default.
- W3160388166 hasRelatedWork W4200272434 @default.
- W3160388166 hasRelatedWork W4311271618 @default.
- W3160388166 isParatext "false" @default.
- W3160388166 isRetracted "false" @default.
- W3160388166 magId "3160388166" @default.
- W3160388166 workType "article" @default.