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• W3160468277 abstract "Our understanding of genome regulation is ever-evolving with the continuous discovery of new modes of gene regulation, and transcriptomic studies of mammalian genomes have revealed the presence of a considerable population of non-coding RNA molecules among the transcripts expressed. One such non-coding RNA molecule is long non-coding RNA (lncRNA). However, the function of lncRNAs in gene regulation is not well understood; moreover, finding conserved lncRNA across species is a challenging task. Therefore, we propose a novel approach to identify conserved lncRNAs and functionally annotate these molecules.In this study, we exploited existing myogenic transcriptome data and identified conserved lncRNAs in mice and humans. We identified the lncRNAs expressing differentially between the early and later stages of muscle development. Differential expression of these lncRNAs was confirmed experimentally in cultured mouse muscle C2C12 cells. We utilized the three-dimensional architecture of the genome and identified topologically associated domains for these lncRNAs. Additionally, we correlated the expression of genes in domains for functional annotation of these trans-lncRNAs in myogenesis. Using this approach, we identified conserved lncRNAs in myogenesis and functionally annotated them.With this novel approach, we identified the conserved lncRNAs in myogenesis in humans and mice and functionally annotated them. The method identified a large number of lncRNAs are involved in myogenesis. Further studies are required to investigate the reason for the conservation of the lncRNAs in human and mouse while their sequences are dissimilar. Our approach can be used to identify novel lncRNAs conserved in different species and functionally annotated them." @default.
• W3160468277 created "2021-05-24" @default.
• W3160468277 creator A5010869970 @default.
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• W3160468277 date "2021-05-10" @default.
• W3160468277 modified "2023-10-06" @default.
• W3160468277 title "Identification of the conserved long non-coding RNAs in myogenesis" @default.
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• W3160468277 doi "https://doi.org/10.1186/s12864-021-07615-0" @default.
• W3160468277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8112034" @default.
• W3160468277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33971818" @default.
• W3160468277 hasPublicationYear "2021" @default.
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