FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160479462> ?p ?o ?g. }

• W3160479462 abstract "Abstract Inflammation is associated with depressive symptoms including anhedonia in patients with major depression. Nevertheless, the mechanisms by which peripheral inflammatory signals are communicated to the brain to influence central nervous system (CNS) function has yet to be fully elucidated. Based on laboratory animal studies, molecules of the kynurenine pathway (KP), which is activated by inflammation, can readily enter the brain, and generate metabolites that can alter neuronal and glial function, leading to behavioral changes. We therefore examined the relationship between KP metabolites in the plasma and cerebrospinal fluid (CSF) and brain chemistry and neural network function using multi-modal neuroimaging in 49 unmedicated, depressed subjects. CNS measures included 1) biochemical markers of glial dysfunction including glutamate (Glu) and myo-inositol (mI) in the left basal ganglia (LBG) using magnetic resonance spectroscopy (MRS); 2) local activity coherence (regional homogeneity, ReHo) and functional connectivity using resting-state functional magnetic resonance imaging; and 3) anhedonia from the Inventory for Depressive Symptoms-Self Reported. Plasma quinolinic acid (QA) was associated with increases and kynurenic acid (KYNA) and KYNA/QA with decreases in LBG Glu. Plasma kynurenine/tryptophan and CSF 3-hydroxy kynurenine (3HK) were associated with increases in LBG mI. Plasma and CSF KP were associated with decreases in ReHo in LBG and dorsomedial prefrontal cortex (DMPFC), and impaired functional connectivity between these two brain regions. DMPFC-BG connectivity mediated the effect of plasma and CSF KP metabolites on anhedonia. These findings highlight the contribution of KP metabolites to glial and neuronal dysfunction and ultimately behavior in depression." @default.
• W3160479462 created "2021-05-24" @default.
• W3160479462 creator A5000433040 @default.
• W3160479462 creator A5002628488 @default.
• W3160479462 creator A5059583278 @default.
• W3160479462 creator A5070908451 @default.
• W3160479462 creator A5076322374 @default.
• W3160479462 creator A5079074820 @default.
• W3160479462 creator A5082654985 @default.
• W3160479462 creator A5084479174 @default.
• W3160479462 creator A5085475946 @default.
• W3160479462 date "2021-05-22" @default.
• W3160479462 modified "2023-09-26" @default.
• W3160479462 title "Kynurenines Increase MRS Metabolites in Basal Ganglia and Decrease Resting State Connectivity in Frontostriatal Reward Circuitry in Depression" @default.
• W3160479462 cites W130054925 @default.
• W3160479462 cites W1484243389 @default.
• W3160479462 cites W1547937746 @default.
• W3160479462 cites W1598480899 @default.
• W3160479462 cites W1861219352 @default.
• W3160479462 cites W1966556202 @default.
• W3160479462 cites W1968629304 @default.
• W3160479462 cites W1969388943 @default.
• W3160479462 cites W1973172818 @default.
• W3160479462 cites W1973712162 @default.
• W3160479462 cites W1977571678 @default.
• W3160479462 cites W1978830885 @default.
• W3160479462 cites W1982737489 @default.
• W3160479462 cites W1994455271 @default.
• W3160479462 cites W2000053835 @default.
• W3160479462 cites W2008557926 @default.
• W3160479462 cites W2008760801 @default.
• W3160479462 cites W2014010113 @default.
• W3160479462 cites W2023798788 @default.
• W3160479462 cites W2024317089 @default.
• W3160479462 cites W2025026106 @default.
• W3160479462 cites W2029753749 @default.
• W3160479462 cites W2035678379 @default.
• W3160479462 cites W2043077656 @default.
• W3160479462 cites W2046572145 @default.
• W3160479462 cites W2053020615 @default.
• W3160479462 cites W2053268711 @default.
• W3160479462 cites W2059032097 @default.
• W3160479462 cites W2060050678 @default.
• W3160479462 cites W2067481238 @default.
• W3160479462 cites W2072059001 @default.
• W3160479462 cites W2072336593 @default.
• W3160479462 cites W2072481403 @default.
• W3160479462 cites W2077902030 @default.
• W3160479462 cites W2078563124 @default.
• W3160479462 cites W2079418286 @default.
• W3160479462 cites W2081070804 @default.
• W3160479462 cites W2086208662 @default.
• W3160479462 cites W2094705589 @default.
• W3160479462 cites W2102532330 @default.
• W3160479462 cites W2104291482 @default.
• W3160479462 cites W2104522961 @default.
• W3160479462 cites W2114613490 @default.
• W3160479462 cites W2126795224 @default.
• W3160479462 cites W2131398580 @default.
• W3160479462 cites W2134305330 @default.
• W3160479462 cites W2138517367 @default.
• W3160479462 cites W2142133137 @default.
• W3160479462 cites W2151702367 @default.
• W3160479462 cites W2165793012 @default.
• W3160479462 cites W2171456544 @default.
• W3160479462 cites W2196461303 @default.
• W3160479462 cites W2210805002 @default.
• W3160479462 cites W2235730659 @default.
• W3160479462 cites W2293194104 @default.
• W3160479462 cites W2338874591 @default.
• W3160479462 cites W2396821322 @default.
• W3160479462 cites W2484423289 @default.
• W3160479462 cites W2494112084 @default.
• W3160479462 cites W2519381186 @default.
• W3160479462 cites W2537037927 @default.
• W3160479462 cites W2560565629 @default.
• W3160479462 cites W2588860206 @default.
• W3160479462 cites W2761045600 @default.
• W3160479462 cites W2793943160 @default.
• W3160479462 cites W2808599394 @default.
• W3160479462 cites W2863186844 @default.
• W3160479462 cites W2892244808 @default.
• W3160479462 cites W2934808888 @default.
• W3160479462 cites W2967819611 @default.
• W3160479462 cites W2999370470 @default.
• W3160479462 cites W3014073663 @default.
• W3160479462 cites W3015503258 @default.
• W3160479462 cites W3048792238 @default.
• W3160479462 cites W3119614451 @default.
• W3160479462 cites W4292811746 @default.
• W3160479462 doi "https://doi.org/10.1101/2021.05.16.21257295" @default.
• W3160479462 hasPublicationYear "2021" @default.
• W3160479462 type Work @default.
• W3160479462 sameAs 3160479462 @default.
• W3160479462 citedByCount "0" @default.
• W3160479462 crossrefType "posted-content" @default.
• W3160479462 hasAuthorship W3160479462A5000433040 @default.
• W3160479462 hasAuthorship W3160479462A5002628488 @default.
• W3160479462 hasAuthorship W3160479462A5059583278 @default.
• W3160479462 hasAuthorship W3160479462A5070908451 @default.

• next