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• W3160497710 abstract "Abstract Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between CAFs and cancer cells is essential for tumor progression and aggressiveness. Cancer cells mediate an activation process, converting normal fibroblasts into CAFs, that are characterized by modified expression of many proteins and increased production and release of microvesicles (MVs), extracellular vesicles generated by outwards budding from the cell membrane. Recent evidence underlined that the uptake of CAF-derived MVs changes the overall protein content of tumor cells. In this paper, we demonstrate that tumor activated fibroblasts overexpress Galectin-1 (Gal-1) and consequently release MVs containing increased levels of this protein. The uptake of Gal-1 enriched MVs by tumor cells leads to the upregulation of its intracellular concentration, that strongly affects cancer cell migration, while neither proliferation nor adhesion are altered. Accordingly, tumor cells co-cultured with fibroblasts silenced for Gal-1 have a reduced migratory ability. The present work reveals the key role of an exogenous protein, Gal-1, derived from activated fibroblasts, in cancer progression, and contributes to clarify the importance of MVs-mediated protein trafficking in regulating tumor-stroma crosstalk." @default.
• W3160497710 created "2021-05-24" @default.
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• W3160497710 date "2021-05-22" @default.
• W3160497710 modified "2023-10-01" @default.
• W3160497710 title "Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1" @default.
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• W3160497710 cites W1983011623 @default.
• W3160497710 cites W1987261184 @default.
• W3160497710 cites W1992339843 @default.
• W3160497710 cites W2010026333 @default.
• W3160497710 cites W2010821717 @default.
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• W3160497710 cites W2044046520 @default.
• W3160497710 cites W2046148841 @default.
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• W3160497710 doi "https://doi.org/10.1007/s12079-021-00624-4" @default.
• W3160497710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8222460" @default.
• W3160497710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34021474" @default.
• W3160497710 hasPublicationYear "2021" @default.
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