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- W3160526082 abstract "It is shown that both DNA polymerase ..cap alpha.. and ..beta.. are involved in DNA synthesis at the nuclear matrix. DNA polymerase ..beta.. is more firmly attached to the nuclear matrix of normal than of regenerating liver cells. In the nuclear matrix of UV- and gamma-irradiated cells of Zajdela hepatoma a higher level of hydroxyurea-resistant DNA synthesis has been observed in the initial 1.5-5 min of postradiation incubation if compared to that of total nuclear DNA. However 1-..beta..-D-arabinofuranosylcytosine-resistant radiation-induced synthesis of DNA is similar in both the nuclear matrix and the whole nuclei of these cells. Poly(ADP-ribose)synthetase activity is shown to be associated with the nuclear matrix. Inhibition of this activity results in increase of the hydroxyurea-resistant synthesis of DNA at nuclear matrix." @default.
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- W3160526082 date "1986-01-01" @default.
- W3160526082 modified "2023-09-26" @default.
- W3160526082 title "DNA polymerase activity and radiation-induced unscheduled synthesis of DNA at the nuclear matrix" @default.
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