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- W3160595554 abstract "Tissue-resident macrophages exist in unique environments, or niches, that inform their identity and function. There is an emerging body of literature suggesting that the qualities of this environment, such as the types of cells and debris they eat, the intercellular interactions they form, and the length of time spent in residence, collectively what we call habitare, directly inform their metabolic state. In turn, a tissue-resident macrophage's metabolic state can inform their function, including whether they resolve inflammation and protect the host from excessive perturbations of homeostasis. In this review, we summarize recent work that seeks to understand the metabolic requirements for tissue-resident macrophage identity and maintenance, for how they respond to inflammatory challenges, and for how they perform homeostatic functions or resolve inflammatory insults. We end with a discussion of the emerging technologies that are enabling, or will enable, in situ study of tissue-resident macrophage metabolism." @default.
- W3160595554 created "2021-05-24" @default.
- W3160595554 creator A5020635318 @default.
- W3160595554 creator A5029078510 @default.
- W3160595554 creator A5082010970 @default.
- W3160595554 creator A5087291985 @default.
- W3160595554 date "2021-05-07" @default.
- W3160595554 modified "2023-10-16" @default.
- W3160595554 title "Immunometabolism of Tissue-Resident Macrophages – An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies" @default.
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