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• W3160611305 abstract "Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (n = 34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n = 94) and without (n = 24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14 800 pg/ml (400, 32 400)], compared to those with encephalopathy [1410 pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740 pg/ml (507, 881)] and controls [872 pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19." @default.
• W3160611305 created "2021-05-24" @default.
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• W3160611305 date "2021-01-01" @default.
• W3160611305 modified "2023-10-12" @default.
• W3160611305 title "Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes" @default.
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• W3160611305 doi "https://doi.org/10.1093/braincomms/fcab099" @default.
• W3160611305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8194666" @default.
• W3160611305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34396099" @default.
• W3160611305 hasPublicationYear "2021" @default.
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