FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160642716> ?p ?o ?g. }

• W3160642716 endingPage "811" @default.
• W3160642716 startingPage "809" @default.
• W3160642716 abstract "Spinocerebellar Ataxia 12(SCA12) is a rare form of SCA, predominantly reported in the ethnic Agarwal population originating from North India. It generally presents with late onset upper limb tremor followed by ataxia.1 Tremor in SCA12 remains poorly studied to date. Since action tremor is the most common and earliest sign in SCA12, it is often mis-diagnosed as Essential tremor.2 In SCA12, CAG repeat associated neuro-toxic protein accumulation accelerates degeneration in the cerebello-cortical region.3 Since toxic protein associated neuro-degeneration is a diffuse process, one may expect appendicular features of SCA12 to reflect symmetry. But asymmetrical hand tremor was documented in one patient of Indian origin by Kalia et al.4 They stated that previous reports did not comment about tremor symmetry, this remains largely true to date. In this paper we have tried to explore if asymmetry of symptoms in SCA12 is an exception or a common finding. We studied 22 cases of SCA12 with a focus on laterality and associated phenomenology of symptoms. Mean disease duration in our study population was 8.2 (±4.7) years. Tremor was clinically analyzed by a movement disorders neurologist. The findings have been summarized in Table 1. When we look into upper limb findings, all 22 (100%) patients had intention tremor, 21 (95%) had dysmetria, 21 (95%) patients had postural tremor and 12 had rest tremor. Interestingly, postural tremor did not depict re-emergence, which is commonly seen in Parkinson's disease. Twenty (91%) patients had asymmetrical upper limb tremor and 10 (45%) had asymmetrical dysmetria. Out of these 20 patients, 19(90%), 10 (83%) and 5 (29%) had asymmetry in postural, rest and intention tremor respectively. Notably, postural tremor showed the highest rate of asymmetry. Only two patients had symmetry in upper limb tremor at presentation but their symptoms started 14 and 16 years ago respectively. Even in these two patients, tremor began on one side and took 5–7 years to equally involve the upper limbs. Twelve patients had simultaneous rest, postural and action tremor, which is defined as Holmes' tremor (HT).5 When analyzing lower limb data, only one patient had action tremor and it was symmetrical. Sixteen patients had dysmetria, all of which was symmetrical. Our findings suggest that asymmetry is a commonly found character of upper limb tremor in SCA12, which can be seen in the representative video segments (Video 1), provided as a supplement to this manuscript. Written informed consent was obtained and ethical approval was taken. Theoretically, HT can be found in any cerebellar outflow tract disorder, but we duly document it in SCA12 for the first time.5 Lower limb tremor was found in only one patient, and it was symmetrical. Dysmetria was more common in lower limbs as compared to tremor, and that too was symmetrical. The clear incongruence in upper and lower limb symptoms in tremor disorders is well reported but unexplained. Well-developed laterality in the upper limbs might make central oscillations manifest better on one side. These oscillations may be dampened in the lower limb due to more crosstalk between bilateral neural tracts. Through our preliminary observation, we conclude that asymmetrical upper limb tremor is a hallmark of SCA12. (1) Research project: A. Conception, B. Organization, C. Execution; (2) Statistical Analysis: A. Design, B. Execution, C. Review and Critique; (3) Manuscript Preparation: A. Writing of the first draft, B. Review and Critique; (4) Supervision. S.B.: 1A, 1B, 1C, 2C, 3A, 3B S.C.: 2A, 2C, 3B U.S.: 1C, 2C, 3C P.B.: 1C, 2C, 3C H.K.: 1A, 1B, 1C, 2A, 3B, 4 This study was approved by the Institute of Neurosciences Kolkata, Institutional Ethics Committee. Written informed consent to publish case reports and videos was obtained from all participants. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. Institutional research fund of HK was used for this study. The authors declare no conflicts of interest relevant to this work. The authors declare that there are no additional disclosures to report." @default.
• W3160642716 created "2021-05-24" @default.
• W3160642716 creator A5000584069 @default.
• W3160642716 creator A5004812347 @default.
• W3160642716 creator A5049101738 @default.
• W3160642716 creator A5062329709 @default.
• W3160642716 creator A5082280984 @default.
• W3160642716 date "2021-05-25" @default.
• W3160642716 modified "2023-10-18" @default.
• W3160642716 title "Asymmetry of Tremor in Spinocerebellar Ataxia 12‐ Exception or Rule?" @default.
• W3160642716 cites W1554320064 @default.
• W3160642716 cites W2014837777 @default.
• W3160642716 cites W2754016241 @default.
• W3160642716 cites W2968712828 @default.
• W3160642716 cites W4214899756 @default.
• W3160642716 doi "https://doi.org/10.1002/mdc3.13237" @default.
• W3160642716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8287153" @default.
• W3160642716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34307760" @default.
• W3160642716 hasPublicationYear "2021" @default.
• W3160642716 type Work @default.
• W3160642716 sameAs 3160642716 @default.
• W3160642716 citedByCount "3" @default.
• W3160642716 countsByYear W31606427162021 @default.
• W3160642716 countsByYear W31606427162022 @default.
• W3160642716 crossrefType "journal-article" @default.
• W3160642716 hasAuthorship W3160642716A5000584069 @default.
• W3160642716 hasAuthorship W3160642716A5004812347 @default.
• W3160642716 hasAuthorship W3160642716A5049101738 @default.
• W3160642716 hasAuthorship W3160642716A5062329709 @default.
• W3160642716 hasAuthorship W3160642716A5082280984 @default.
• W3160642716 hasBestOaLocation W31606427161 @default.
• W3160642716 hasConcept C142724271 @default.
• W3160642716 hasConcept C15744967 @default.
• W3160642716 hasConcept C169760540 @default.
• W3160642716 hasConcept C2776477761 @default.
• W3160642716 hasConcept C2776936178 @default.
• W3160642716 hasConcept C2777154897 @default.
• W3160642716 hasConcept C2778261627 @default.
• W3160642716 hasConcept C2779134260 @default.
• W3160642716 hasConcept C2779500118 @default.
• W3160642716 hasConcept C2779734285 @default.
• W3160642716 hasConcept C2780112193 @default.
• W3160642716 hasConcept C2780294739 @default.
• W3160642716 hasConcept C2780906641 @default.
• W3160642716 hasConcept C2908647359 @default.
• W3160642716 hasConcept C2910515783 @default.
• W3160642716 hasConcept C2911210631 @default.
• W3160642716 hasConcept C71924100 @default.
• W3160642716 hasConcept C99454951 @default.
• W3160642716 hasConcept C99508421 @default.
• W3160642716 hasConceptScore W3160642716C142724271 @default.
• W3160642716 hasConceptScore W3160642716C15744967 @default.
• W3160642716 hasConceptScore W3160642716C169760540 @default.
• W3160642716 hasConceptScore W3160642716C2776477761 @default.
• W3160642716 hasConceptScore W3160642716C2776936178 @default.
• W3160642716 hasConceptScore W3160642716C2777154897 @default.
• W3160642716 hasConceptScore W3160642716C2778261627 @default.
• W3160642716 hasConceptScore W3160642716C2779134260 @default.
• W3160642716 hasConceptScore W3160642716C2779500118 @default.
• W3160642716 hasConceptScore W3160642716C2779734285 @default.
• W3160642716 hasConceptScore W3160642716C2780112193 @default.
• W3160642716 hasConceptScore W3160642716C2780294739 @default.
• W3160642716 hasConceptScore W3160642716C2780906641 @default.
• W3160642716 hasConceptScore W3160642716C2908647359 @default.
• W3160642716 hasConceptScore W3160642716C2910515783 @default.
• W3160642716 hasConceptScore W3160642716C2911210631 @default.
• W3160642716 hasConceptScore W3160642716C71924100 @default.
• W3160642716 hasConceptScore W3160642716C99454951 @default.
• W3160642716 hasConceptScore W3160642716C99508421 @default.
• W3160642716 hasIssue "5" @default.
• W3160642716 hasLocation W31606427161 @default.
• W3160642716 hasLocation W31606427162 @default.
• W3160642716 hasLocation W31606427163 @default.
• W3160642716 hasOpenAccess W3160642716 @default.
• W3160642716 hasPrimaryLocation W31606427161 @default.
• W3160642716 hasRelatedWork W1973811412 @default.
• W3160642716 hasRelatedWork W1983483138 @default.
• W3160642716 hasRelatedWork W2061485790 @default.
• W3160642716 hasRelatedWork W2787946293 @default.
• W3160642716 hasRelatedWork W2935894013 @default.
• W3160642716 hasRelatedWork W3133640910 @default.
• W3160642716 hasRelatedWork W3181984257 @default.
• W3160642716 hasRelatedWork W4241969133 @default.
• W3160642716 hasRelatedWork W4299807410 @default.
• W3160642716 hasRelatedWork W51246064 @default.
• W3160642716 hasVolume "8" @default.
• W3160642716 isParatext "false" @default.
• W3160642716 isRetracted "false" @default.
• W3160642716 magId "3160642716" @default.
• W3160642716 workType "article" @default.