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- W3160688576 abstract "Gastroesophageal reflux disease (GERD) and obesity are common disorders in the developed world, often coinciding in the same patients [1]. Obesity exacerbates GERD and reduces the efficacy of anti-reflux surgery [2]. This creates management challenges for overlapping GERD and obesity, which compels the development of safe, effective, and durable therapies for patients with these conditions. The Incisionless Operating Platform (USGI Medical, San Clemente, California, USA) is a handheld endoscopic tool that acquires full-thickness gastric or gastroesophageal tissue using 3.3-cm jaws. The tissue is then pierced with a catheter needle to allow for the deployment of paired suture anchors, thereby creating a 6.6-cm full-thickness plication ([Video 1]). The Incisionless Operating Platform may be operated in both the forward-facing and retroflexed orientation. This unique feature permits the endoscopic creation of plications that both facilitate weight loss (such as those used in the Primary Obesity Surgery Endoluminal gastric remodeling procedure), as well as plications at the gastroesophageal junction that may serve as a barrier against pathologic reflux (such as those used in transoral incisionless fundoplication) [3] [4]. The Incisionless Operating Platform consequently provides the theoretical opportunity to co-treat obesity and GERD in the same patient during a single procedure ([Fig. 1]). In this video, we describe the use of the platform to create gastric plications in the pattern of the Primary Obesity Surgery Endoluminal 2 procedure, which tubularizes the stomach along the greater curvature and shortens its aperture to facilitate weight loss in adults with obesity. We then describe the use of the Incisionless Operating Platform to create gastric and gastroesophageal plications to serve as a barrier against gastroesophageal reflux in a large canine model. We conclude with the combination plication procedure in an ex-vivo porcine stomach, providing the conceptual framework for examining the combination procedure in humans." @default.
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- W3160688576 date "2021-05-12" @default.
- W3160688576 modified "2023-10-17" @default.
- W3160688576 title "Feasibility of a single endoscopic plication procedure for the treatment of gastroesophageal reflux disease and obesity" @default.
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- W3160688576 doi "https://doi.org/10.1055/a-1481-7844" @default.
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