Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160693468> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3160693468 abstract "Background: TP53 gene is one of the most frequent alterations, and heterogeneity in immune cell content is found in hepatocellular carcinoma (HCC). However, TP53 mutations associated immunotype of HCC has not been reported. This study aimed to identify the TP53 mutations associated immunotype.Methods: The mutation annotation format (MAF) document, mRNA expression data and clinical data of HCC patients were downloaded from the publicly available TCGA (The Cancer Genome Atlas) data portal. 332 HCC patients were finally incorporate into this study. Infiltrating immune cells were evaluated by well-known CIBERSORT method. Another mutation data of HCC patients was downloaded from the COSMIC (Catalogue of Somatic Mutations in Cancer) database.Findings: TP53 was the gene harboring the highest frequency of mutations. Subsequently, 5 lethal features including TP53 mutations were screen by LASSO (Least absolute shrinkage and selector operation)-COX regression according to TP53 mutations and 22 infiltrating immune cells. And then, two distinct subgroups of HCC were identified according to previous five lethal features. What's more, the expression levels of co-inhibitory immune checkpoints were significantly up-regulated, and the GO terms or pathways to boost immune responses were found to be inhibited in immunotype B subgroup compared with that in immunotype A subgroup. Finally, the immunotype was proved to be an independent adverse prognostic factor, contribute to improving the predictive accuracy of the immunotype-based model and avoiding excessive medical treatment.Interpretation: Stratification of tumors is paramount to achieve better clinical outcomes. Herein, two distinct immunotypes of HCC in terms of prognosis, phenotype, and function were identified and subverted the traditional understanding of intratumoral CD8+ T cells. Moreover, the immunotypes contributed to improving the predictive accuracy and avoiding excessive medical treatment of some HCC patients.Funding: This study was funded by grants from the National Natural Science Foundation of China (81401988 and 81770266), the Six talent peaks project in Jiangsu Province (WSN-060) and the Key talents of youth medicine in Jiangsu Provincial Department of health (QNRC2016681).Declaration of Interest: The authors have declared that no conflicts of interest exist." @default.
- W3160693468 created "2021-05-24" @default.
- W3160693468 creator A5003642180 @default.
- W3160693468 creator A5028725880 @default.
- W3160693468 creator A5045071454 @default.
- W3160693468 creator A5046363445 @default.
- W3160693468 creator A5047984251 @default.
- W3160693468 creator A5061606271 @default.
- W3160693468 creator A5074711274 @default.
- W3160693468 date "2019-01-01" @default.
- W3160693468 modified "2023-10-17" @default.
- W3160693468 title "Identification of TP53 Mutation Associated-Immunotype and Prediction of Survival in Patients with Hepatocellular Carcinoma" @default.
- W3160693468 doi "https://doi.org/10.2139/ssrn.3393688" @default.
- W3160693468 hasPublicationYear "2019" @default.
- W3160693468 type Work @default.
- W3160693468 sameAs 3160693468 @default.
- W3160693468 citedByCount "0" @default.
- W3160693468 crossrefType "journal-article" @default.
- W3160693468 hasAuthorship W3160693468A5003642180 @default.
- W3160693468 hasAuthorship W3160693468A5028725880 @default.
- W3160693468 hasAuthorship W3160693468A5045071454 @default.
- W3160693468 hasAuthorship W3160693468A5046363445 @default.
- W3160693468 hasAuthorship W3160693468A5047984251 @default.
- W3160693468 hasAuthorship W3160693468A5061606271 @default.
- W3160693468 hasAuthorship W3160693468A5074711274 @default.
- W3160693468 hasConcept C104317684 @default.
- W3160693468 hasConcept C10515644 @default.
- W3160693468 hasConcept C126322002 @default.
- W3160693468 hasConcept C127716648 @default.
- W3160693468 hasConcept C203014093 @default.
- W3160693468 hasConcept C2778019345 @default.
- W3160693468 hasConcept C501734568 @default.
- W3160693468 hasConcept C502942594 @default.
- W3160693468 hasConcept C50382708 @default.
- W3160693468 hasConcept C54355233 @default.
- W3160693468 hasConcept C71924100 @default.
- W3160693468 hasConcept C86803240 @default.
- W3160693468 hasConcept C8891405 @default.
- W3160693468 hasConceptScore W3160693468C104317684 @default.
- W3160693468 hasConceptScore W3160693468C10515644 @default.
- W3160693468 hasConceptScore W3160693468C126322002 @default.
- W3160693468 hasConceptScore W3160693468C127716648 @default.
- W3160693468 hasConceptScore W3160693468C203014093 @default.
- W3160693468 hasConceptScore W3160693468C2778019345 @default.
- W3160693468 hasConceptScore W3160693468C501734568 @default.
- W3160693468 hasConceptScore W3160693468C502942594 @default.
- W3160693468 hasConceptScore W3160693468C50382708 @default.
- W3160693468 hasConceptScore W3160693468C54355233 @default.
- W3160693468 hasConceptScore W3160693468C71924100 @default.
- W3160693468 hasConceptScore W3160693468C86803240 @default.
- W3160693468 hasConceptScore W3160693468C8891405 @default.
- W3160693468 hasLocation W31606934681 @default.
- W3160693468 hasOpenAccess W3160693468 @default.
- W3160693468 hasPrimaryLocation W31606934681 @default.
- W3160693468 hasRelatedWork W1971486049 @default.
- W3160693468 hasRelatedWork W2034103052 @default.
- W3160693468 hasRelatedWork W2041471326 @default.
- W3160693468 hasRelatedWork W2050197467 @default.
- W3160693468 hasRelatedWork W2080475388 @default.
- W3160693468 hasRelatedWork W2105349348 @default.
- W3160693468 hasRelatedWork W2429539248 @default.
- W3160693468 hasRelatedWork W2444068696 @default.
- W3160693468 hasRelatedWork W3198587835 @default.
- W3160693468 hasRelatedWork W4248183732 @default.
- W3160693468 isParatext "false" @default.
- W3160693468 isRetracted "false" @default.
- W3160693468 magId "3160693468" @default.
- W3160693468 workType "article" @default.