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• W3160705237 abstract "Investigation on tannins having antitumor properties led to the isolation of two new C -glycosidic ellagitannins ( 1 and 2 ) along with seven known ellagitannins ( 3 – 9 ) and a related polyphenolic constituent ( 10 ) from Lawsonia inermis leaves. Our intensive HRESIMS, 1D and 2D NMR, and ECD spectroscopic studies of new tannins have shown that one ( 1 ) has a monomer structure of C -glycosidic tannin, and the other ( 2 ) has a dimeric structure of 2,3- O -hexahydroxydiphenoyl glucopyranose and a C -glycosidic tannin. Among the known compounds, one ( 3 ) is a C -glycosidic tannin that was isolated first of all from nature, five were C -glycosidic tannins, vescalagin ( 4 ), 1- O -methylvescalagin ( 5 ), castalagin ( 6 ), stachyurin ( 7 ), and casuarinin ( 8 ), and one was an O- glycosidic ellagitannin, tellimagrandin II ( 9 ). The remaining phenolic constituent from the leaves was identified as valoneic acid dilactone ( 10 ). The ellagitannins 1 , and 3 – 9 demonstrated noticeable cytotoxicity on human oral squamous cell carcinoma cell lines (HSC-2, HSC-4, and Ca9–22), and lower effects on human oral normal cells (HGF, HPC, and HPLF). Tellimagrandin II ( 9 ) had the highest tumor-specific cytotoxicity, and also cleaved poly (ADP-ribose) polymerase 1 in HSC-2 cells. These findings showed that L. inermis ellagitannins may be a candidate for the production of anti-oral cancer materials. • Two new ( 1 and 2 ), a first isolated from nature ( 3 ), and six knowns ( 4 – 9 ) ellagitannins, and a related phenolic ( 10 ) were isolated from leaves of L. inermis . • The ellagitannins ( 1 , 3 – 9 ) exhibited higher cytotoxicity against human oral cancer cell lines (HSC-2, HSC-4, and Ca9–22) than against human normal oral cells (HGF, HPC, and HPLF). • Tellimagrandin II ( 9 ) induced cleavage of PARP1 in HSC-2 cells." @default.
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• W3160705237 date "2021-09-01" @default.
• W3160705237 modified "2023-09-23" @default.
• W3160705237 title "Two new C-glycosidic ellagitannins and accompanying tannins from Lawsonia inermis leaves and their cytotoxic effects" @default.
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• W3160705237 doi "https://doi.org/10.1016/j.fitote.2021.104925" @default.
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