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• W3160720453 abstract "INTRODUCTION: Dietary omega-3 fatty acid (FA) has cardioprotective effect and is associated with a slower deterioration of albumin excretion. There is no report about the effect of omega-3 FA on proteinuria in patients with diabetic nephropathy who are well controlled blood pressure with angiotensin converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB). We hypothesized that omega-3 FA supplementation decrease proteinuria and change erythrocyte membrane FA contents which is related with acute coronary syndrome in patients with diabetic nephropathy. METHODS: In a double-blind randomized placebo-controlled design, a total of 19 patients treated with ACEI or ARB, was randomized to treatment for 12 weeks with omega-3 FA or a control treatment. We measured proteinuria with random spot urine and urine collected for 24 hours. Urinary liver-type fatty acid binding protein (L-FABP), prostaglandin E2 (PGE2) and neutrophil gelatinase-associated lipocalin (NGAL) were measured by enzyme-linked immunoassay. Erythrocyte membrane fatty acid contents were measured by gas chromatography. RESULTS: The mean age of the enrolled patients was 60.4±10.7 years and mean blood pressure was 121/72 mmHg. Baseline urinary protein to creatinine ratio, 24 hours urine protein and serum creatinine were 0.74±0.65 g/g, 0.53±0.53 g and 1.23±0.20 mg/dL. Blood pressure, proteinuria, albuminuria (443.2±614.6 mg/g vs. 348.0±390.6 mg/g), serum creatinine, L-FABP, PGE2, NGAL (35.1±57.2 ng/mL vs. 25.4±17.8 ng/mL) and lipid profile were not significantly changed in omega-3 FA supplemented group after 12 weeks compared to baseline. The eryt! hrocyte membrane contents of eicosapentaenoic acid (EPA) (p=0.025) were significantly increased and arachidonic acid to EPA ratio (p=0.012) and oleic acid (15.8±2.9 % vs. 13.1±2.2 %, p=0.036) were significantly decreased in omega-3 FA supplemented group after 12 weeks compared to baseline. CONCLUSIONS: Although there is no additive effect of omega-3 FA on proteinuria, FA contents of erythrocyte membrane were significantly changed by omega-3 FA treatment for 12 weeks in patients with diabetic nephropathy who are well controlled blood pressure with ACEI or ARB." @default.
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• W3160720453 date "2011-01-01" @default.
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• W3160720453 title "Effect of omega-3 fatty acid on oleic acid of erythrocyte membrane in patients with overt diabetic nephropathy" @default.
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