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- W3160738538 abstract "Intralymphatic histiocytosis (IH) is a rare disease with variable and nonspecific clinical features, but with characteristic histopathological findings. Histopathologically, dilated lymphatic vessels containing aggregates of mononuclear cells are observed in the reticular dermis. IH is often associated with other diseases; such as rheumatoid arthritis, osteoarthritis, joint metal implantation, and breast cancer occurred over mastectomy scar. Although the pathogenesis of IH is not defined, some authors suggest that lymphatic vessel engorgement by histiocytes migrating from neighboring inflammatory reactions may play a key pathogenic role. A 50-year-old female presented with multiple tender erythematous plaques on both breast and right shoulder. On past history, she underwent both breast conservation operation 3 years ago. Laboratory findinds were WBC 12,340/mm3, neutrophil 88.1%, ESR 10mm/hr, CRP 9.73mg/dL and procalcitonin 0.089ng/mL. Histopathologic findings showed irregularly dilated vessels with intraluminal cells in dermis. Endothelial cells lining the vessels were positive for D2-40 staining, which is a marker for lymphatic endothelial cells, and intraluminal cells were positive for CD68 staining, which is a marker for histiocytes. She improved with conservative therapy. To our knowledge, this is the first case of IH in association with breast cancer in the Korean dermatologic literature." @default.
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- W3160738538 date "2017-01-01" @default.
- W3160738538 modified "2023-09-23" @default.
- W3160738538 title "[P322] A case of intralymphatic histiocytosis associated with breast cancer" @default.
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