Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160810716> ?p ?o ?g. }
- W3160810716 abstract "As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants which is of particular concern due to their potential for increased transmissibility and pathology. In addition to this entrenched variant diversity in circulation, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolving differently in distinct cell types. The BriS{Delta} variant, originally identified as a viral subpopulation by passaging SARS-CoV-2 isolate hCoV-19/England/02/2020, comprises in the spike glycoprotein an eight amino-acid deletion encompassing the furin recognition motif and S1/S2 cleavage site. Here, we elucidate the structure, function and molecular dynamics of this variant spike providing mechanistic insight into how the deletion correlates to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant. Moreover, our study reveals long-range allosteric communication between functional regions within the spike that differ in wild-type and deletion variant. Our results support a view of SARS-CoV-2 probing multiple evolutionary trajectories in distinct cell types within the same infected host." @default.
- W3160810716 created "2021-05-24" @default.
- W3160810716 creator A5005998309 @default.
- W3160810716 creator A5011195205 @default.
- W3160810716 creator A5013037530 @default.
- W3160810716 creator A5013411572 @default.
- W3160810716 creator A5013799671 @default.
- W3160810716 creator A5030664364 @default.
- W3160810716 creator A5038062129 @default.
- W3160810716 creator A5044560485 @default.
- W3160810716 creator A5056810919 @default.
- W3160810716 creator A5060456316 @default.
- W3160810716 creator A5060586851 @default.
- W3160810716 creator A5064578149 @default.
- W3160810716 creator A5077652674 @default.
- W3160810716 creator A5078208432 @default.
- W3160810716 creator A5086749128 @default.
- W3160810716 creator A5091178241 @default.
- W3160810716 creator A5091411835 @default.
- W3160810716 date "2021-05-11" @default.
- W3160810716 modified "2023-10-16" @default.
- W3160810716 title "Structure and mechanism of SARS-CoV-2 Spike N679-V687 deletion variant elucidate cell-type specific evolution of viral fitness" @default.
- W3160810716 cites W1838872057 @default.
- W3160810716 cites W1986191025 @default.
- W3160810716 cites W1994915168 @default.
- W3160810716 cites W2026920658 @default.
- W3160810716 cites W2029667189 @default.
- W3160810716 cites W2035687084 @default.
- W3160810716 cites W2044514683 @default.
- W3160810716 cites W2045683699 @default.
- W3160810716 cites W2051269276 @default.
- W3160810716 cites W2064140868 @default.
- W3160810716 cites W2098167941 @default.
- W3160810716 cites W2104234755 @default.
- W3160810716 cites W2118233996 @default.
- W3160810716 cites W2124026197 @default.
- W3160810716 cites W2127322768 @default.
- W3160810716 cites W2132629607 @default.
- W3160810716 cites W2137548222 @default.
- W3160810716 cites W2147993766 @default.
- W3160810716 cites W2154714625 @default.
- W3160810716 cites W2161605421 @default.
- W3160810716 cites W2171268876 @default.
- W3160810716 cites W2327255986 @default.
- W3160810716 cites W2518262267 @default.
- W3160810716 cites W2593511418 @default.
- W3160810716 cites W2788833468 @default.
- W3160810716 cites W2945767907 @default.
- W3160810716 cites W2950967305 @default.
- W3160810716 cites W2951611668 @default.
- W3160810716 cites W2953798760 @default.
- W3160810716 cites W2973457155 @default.
- W3160810716 cites W3005409321 @default.
- W3160810716 cites W3007643904 @default.
- W3160810716 cites W3009335299 @default.
- W3160810716 cites W3009912996 @default.
- W3160810716 cites W3010955108 @default.
- W3160810716 cites W3011246056 @default.
- W3160810716 cites W3013093478 @default.
- W3160810716 cites W3013800395 @default.
- W3160810716 cites W3016591679 @default.
- W3160810716 cites W3022435472 @default.
- W3160810716 cites W3025631553 @default.
- W3160810716 cites W3036391214 @default.
- W3160810716 cites W3040801746 @default.
- W3160810716 cites W3041603492 @default.
- W3160810716 cites W3042332408 @default.
- W3160810716 cites W3043391491 @default.
- W3160810716 cites W3081204841 @default.
- W3160810716 cites W3084653951 @default.
- W3160810716 cites W3086145326 @default.
- W3160810716 cites W3087347658 @default.
- W3160810716 cites W3087409770 @default.
- W3160810716 cites W3093867667 @default.
- W3160810716 cites W3094419073 @default.
- W3160810716 cites W3096068717 @default.
- W3160810716 cites W3099182481 @default.
- W3160810716 cites W3112376646 @default.
- W3160810716 cites W3122148095 @default.
- W3160810716 cites W3122289283 @default.
- W3160810716 cites W3122346468 @default.
- W3160810716 cites W3127581366 @default.
- W3160810716 cites W3128335178 @default.
- W3160810716 cites W3128348678 @default.
- W3160810716 cites W3133133483 @default.
- W3160810716 cites W3133712402 @default.
- W3160810716 cites W3137359073 @default.
- W3160810716 cites W3159140204 @default.
- W3160810716 cites W45709026 @default.
- W3160810716 hasPublicationYear "2021" @default.
- W3160810716 type Work @default.
- W3160810716 sameAs 3160810716 @default.
- W3160810716 citedByCount "0" @default.
- W3160810716 crossrefType "posted-content" @default.
- W3160810716 hasAuthorship W3160810716A5005998309 @default.
- W3160810716 hasAuthorship W3160810716A5011195205 @default.
- W3160810716 hasAuthorship W3160810716A5013037530 @default.
- W3160810716 hasAuthorship W3160810716A5013411572 @default.
- W3160810716 hasAuthorship W3160810716A5013799671 @default.
- W3160810716 hasAuthorship W3160810716A5030664364 @default.