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• W3160811746 abstract "INTRODUCTION: Preclinical studies (PS) aiming to evaluate the microenvironment of breast cancer (BC) is very important for analysis of risk and the behavior of this disease to treatments proposed in humans, such as fat grafting to the breast (FGB). These studies, however, present serious methodological problems. They are based on models that use cancer-induced carcinogens that have a residual systemic effect or through the use of nonluminal human BC implanted in immunosuppressed murine hosts. Thus, this study objectives to analyze the effectiveness of cafeteria diet (CD) to trigger BC and yield enough fat for autologous grafting, in order to create a preclinical model able to analyze oncological safety of FGB in immunocompetent hosts. METHODS: Sixty Sprague-Dawley rats with 28 days-of-life were randomly divided into 6 groups, according to their period of life (adolescent = 1, adult = 2, reproductive-senescence = 3): 3 controls (C1, C2, C3), fed with standard diet, and 3 groups that received CD (D1, D2, D3). CD was introduced at rats age of 6 weeks, when they reach sexual maturity. The following variables were collected and analyzed: weight, naso-anal length, Lee Index (LI), fasting glycemia (FG), perigonadal fat pad weight (PFW), and groin fat pad volume (GFV). Six thoracic breasts, adipose tissue of omentum, and subcutaneous of each rat were harvested for analysis. These samples were studied through histological analysis with HE staining. Statistical analyses were performed using paired t tests, analysis of variance (one way) for ordinal variables and McNemar’s test for categorical variables. RESULTS: The mean weight of rats analyzed with 26 weeks old was 263.09 g in C1 and 426.76 g in D1 (P < 0.001). The mean LI, were respectively, 298.12 and 332.63 in Groups C1 and D1 (P = 0.002). The mean FG value was 76.06 mg/dl (P = 0.26); the mean PFW was 8.21 g (P < 0.001). The mean GFV was 5.08 ml (P = 0.001). The mammary microenvironment between adolescent rats shows 20% of duct ectasia (DE) in CD versus 8% in control (P < 0.001) within 11 only weeks under CD. One fibroadenoma was observed in CD at 12th week after cafeteria diet onset and other at the 13th. In adult phase (between 210 and 600 days old), 42 rats (C2, D2) were analyzed for tumorigenic status. In D2, 6 rats had tumor (3 adenocarcinomas, 3 fibroadenomas) versus 2 rats in C2 (1 adenocarcinoma, 1 fibroadenomas). Thirty rats (C3, D3) remained for analysis of any residual effect of CD in reproductive-senescence period. Mean weight in C3 was 318.68 g and in D3, 382,11 g (P = 0.01). Mean LI, were respectively, 326.50 and 337.889 in C3 and D3 (P = 0.39). FG value was 89.43 mg/dl in control versus 91.80 in CD (P = 0.36). Values for PFW and GFV were statically different between CD and control, respectively representing P = 0.046 and P = 0.022. CONCLUSION: This study showed that the CD not only produce enough fat for autologous grafting, as well as it was an effective method to induce BC in adult rats without bias related to the inductor agent, even in reproductive-senescence period. Thus, this preclinical model of BC in immunocompetent hosts can be effectively used to analyze the oncological safety of FGB in breasts with residual cancer." @default.
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• W3160811746 date "2020-09-01" @default.
• W3160811746 modified "2023-10-16" @default.
• W3160811746 title "A Preclinical Model to Analyze the Oncological Safety of Fat Grafting in Breasts With Residual Cancer in Immunocompetent Hosts" @default.
• W3160811746 doi "https://doi.org/10.1097/01.gox.0000721060.57491.c3" @default.
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