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- W3160926096 abstract "A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and elemental analysis. The synthesized oxazine and Schiff’s bases of oxazine were docked against protein cyclooxygensase target especially selective COX-2. The invitro anti-inflammatory and antioxidant studies of the synthesized compounds were carried out and the results of the docking scores were in correlation with their obtained biological activity." @default.
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- W3160926096 date "2021-01-01" @default.
- W3160926096 modified "2023-09-26" @default.
- W3160926096 title "Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents" @default.
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