FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3160990505> ?p ?o ?g. }

• W3160990505 endingPage "538" @default.
• W3160990505 startingPage "538" @default.
• W3160990505 abstract "Prostate cancer chemoresistance is a major therapeutic problem, and the underlying mechanism is not well understood and effective therapies to overcome this problem are not available. Phosphodiesterase-4 (PDE4), a main intracellular enzyme for cAMP hydrolysis, has been previously shown to involve in the early chemo-sensitive prostate cancer cell proliferation and progression, but its role in the more-advanced chemo-resistant prostate cancer is completely unknown. Here we found that the expression of PDE4 subtype, PDE4D, is highly elevated in the chemo-resistant prostate cancer cells (DU145-TxR and PC3-TxR) in comparison to the chemo-sensitive prostate cancer cells (DU145 and PC3). Inhibition of PDE4D with a potent and selective PDED4 inhibitor, Eggmanone, effectively decreases the invasion and proliferation as well as induces cell death of the chemo-resistant prostate cancer cells (DU145-TxR and PC3-TxR). These results were confirmed by siRNA knockdown of PDE4D. We and colleagues previously reported that Eggmanone can effectively blocked sonic Hedgehog signaling via PDE4D inhibition, and here our study suggests that that Eggmanone downregulated proliferation of the chemo-resistant prostate cancer cells via sonic Hedgehog signaling. In addition, Eggmanone treatment dose-dependently increases docetaxel cytotoxicity to DU145-TxR and PC3-TxR. As cancer stem cells (CSCs) are known to be implicated in cancer chemoresistance, we further examined Eggmanone impacts on CSC-like properties in the chemo-resistant prostate cancer cells. Our study shows that Eggmanone effectively down-regulates the expression of CSCs’ marker genes Nanog and ABC sub-family G member 2 (ABCG2) and attenuates sphere formation in DU145-TxR and PC3-TxR cells. In summary, our work shows that Eggmanone effectively overcomes the chemoresistance of prostate cancer cells presumably through sonic Hedgehog signaling and targeting CSCs, suggesting that Eggmanone may serve as a novel agent for chemo-resistant prostate cancer." @default.
• W3160990505 created "2021-05-24" @default.
• W3160990505 creator A5046138088 @default.
• W3160990505 creator A5059224542 @default.
• W3160990505 creator A5062314091 @default.
• W3160990505 date "2021-05-12" @default.
• W3160990505 modified "2023-09-25" @default.
• W3160990505 title "Eggmanone Effectively Overcomes Prostate Cancer Cell Chemoresistance" @default.
• W3160990505 cites W193983472 @default.
• W3160990505 cites W1966844804 @default.
• W3160990505 cites W1988230171 @default.
• W3160990505 cites W1997277329 @default.
• W3160990505 cites W1997845879 @default.
• W3160990505 cites W1998242846 @default.
• W3160990505 cites W2000934648 @default.
• W3160990505 cites W2007571390 @default.
• W3160990505 cites W2023192737 @default.
• W3160990505 cites W2023427658 @default.
• W3160990505 cites W2026969458 @default.
• W3160990505 cites W2028051779 @default.
• W3160990505 cites W2029299795 @default.
• W3160990505 cites W2032845267 @default.
• W3160990505 cites W2043954875 @default.
• W3160990505 cites W2063514430 @default.
• W3160990505 cites W2066235353 @default.
• W3160990505 cites W2080431493 @default.
• W3160990505 cites W2086770774 @default.
• W3160990505 cites W2088359631 @default.
• W3160990505 cites W2089470358 @default.
• W3160990505 cites W2099853576 @default.
• W3160990505 cites W2100639629 @default.
• W3160990505 cites W2102828824 @default.
• W3160990505 cites W2119776733 @default.
• W3160990505 cites W2120292596 @default.
• W3160990505 cites W2124142551 @default.
• W3160990505 cites W2124331403 @default.
• W3160990505 cites W2125923072 @default.
• W3160990505 cites W2134066544 @default.
• W3160990505 cites W2140536163 @default.
• W3160990505 cites W2150865892 @default.
• W3160990505 cites W2152835042 @default.
• W3160990505 cites W2154067158 @default.
• W3160990505 cites W2214621962 @default.
• W3160990505 cites W2415653838 @default.
• W3160990505 cites W2460420395 @default.
• W3160990505 cites W2522813048 @default.
• W3160990505 cites W2528748907 @default.
• W3160990505 cites W2554565213 @default.
• W3160990505 cites W2736936534 @default.
• W3160990505 cites W2790421467 @default.
• W3160990505 cites W2889336950 @default.
• W3160990505 cites W2889646458 @default.
• W3160990505 cites W3056698446 @default.
• W3160990505 cites W4254002644 @default.
• W3160990505 cites W4254731271 @default.
• W3160990505 doi "https://doi.org/10.3390/biomedicines9050538" @default.
• W3160990505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8151738" @default.
• W3160990505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34066000" @default.
• W3160990505 hasPublicationYear "2021" @default.
• W3160990505 type Work @default.
• W3160990505 sameAs 3160990505 @default.
• W3160990505 citedByCount "1" @default.
• W3160990505 countsByYear W31609905052022 @default.
• W3160990505 crossrefType "journal-article" @default.
• W3160990505 hasAuthorship W3160990505A5046138088 @default.
• W3160990505 hasAuthorship W3160990505A5059224542 @default.
• W3160990505 hasAuthorship W3160990505A5062314091 @default.
• W3160990505 hasBestOaLocation W31609905051 @default.
• W3160990505 hasConcept C121608353 @default.
• W3160990505 hasConcept C126322002 @default.
• W3160990505 hasConcept C185592680 @default.
• W3160990505 hasConcept C2776438761 @default.
• W3160990505 hasConcept C2779723316 @default.
• W3160990505 hasConcept C2780192828 @default.
• W3160990505 hasConcept C502942594 @default.
• W3160990505 hasConcept C55427017 @default.
• W3160990505 hasConcept C71924100 @default.
• W3160990505 hasConcept C86803240 @default.
• W3160990505 hasConcept C96232424 @default.
• W3160990505 hasConceptScore W3160990505C121608353 @default.
• W3160990505 hasConceptScore W3160990505C126322002 @default.
• W3160990505 hasConceptScore W3160990505C185592680 @default.
• W3160990505 hasConceptScore W3160990505C2776438761 @default.
• W3160990505 hasConceptScore W3160990505C2779723316 @default.
• W3160990505 hasConceptScore W3160990505C2780192828 @default.
• W3160990505 hasConceptScore W3160990505C502942594 @default.
• W3160990505 hasConceptScore W3160990505C55427017 @default.
• W3160990505 hasConceptScore W3160990505C71924100 @default.
• W3160990505 hasConceptScore W3160990505C86803240 @default.
• W3160990505 hasConceptScore W3160990505C96232424 @default.
• W3160990505 hasIssue "5" @default.
• W3160990505 hasLocation W31609905051 @default.
• W3160990505 hasLocation W31609905052 @default.
• W3160990505 hasOpenAccess W3160990505 @default.
• W3160990505 hasPrimaryLocation W31609905051 @default.
• W3160990505 hasRelatedWork W2045315430 @default.
• W3160990505 hasRelatedWork W2052103316 @default.
• W3160990505 hasRelatedWork W2286070056 @default.

• next