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- W3161036122 endingPage "2467" @default.
- W3161036122 startingPage "2467" @default.
- W3161036122 abstract "The study of the interactions occurring in the BM environment has been facilitated by the peculiar nature of metastatic NB. In fact: (i) metastases are present at diagnosis; (ii) metastases are confined in a very specific tissue, the BM, suggestive of a strong attraction and possibility of survival; (iii) differently from adult cancers, NB metastases are available because the diagnostic procedures require morphological examination of BM; (iv) NB metastatic cells express surface antigens that allow enrichment of NB metastatic cells by immune–magnetic separation; and (v) patients with localized disease represent an internal control to discriminate specific alterations occurring in the metastatic niche from generic alterations determined by the neoplastic growth at the primary site. Here, we first review the information regarding the features of BM-infiltrating NB cells. Then, we focus on the alterations found in the BM of children with metastatic NB as compared to healthy children and children with localized NB. Specifically, information regarding all the BM cell populations and their sub-sets will be first examined in the context of BM microenvironment in metastatic NB. In the last part, the information regarding the soluble factors will be presented." @default.
- W3161036122 created "2021-05-24" @default.
- W3161036122 creator A5000242295 @default.
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- W3161036122 creator A5053922930 @default.
- W3161036122 creator A5062757807 @default.
- W3161036122 creator A5075091660 @default.
- W3161036122 date "2021-05-19" @default.
- W3161036122 modified "2023-10-11" @default.
- W3161036122 title "Bone Marrow Environment in Metastatic Neuroblastoma" @default.
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