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- W3161053473 abstract "Herein, we report the synthesis and characterization of a bishomoleptic and a trisheteroleptic ruthenium (II) polypyridyl complex, namely, [Ru(bpy)2(2, 2′-pq)](PF6)2 (1) and [Ru(bpy) (phen) (2, 2′-pq)](PF6)2 (2), respectively, where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, and 2, 2′-pq = 2-(2′-pyridyl)-quinoxaline. The complexes were characterized by elemental analysis, TGA, 1H-NMR, FT-IR, UV-Vis, emission spectroscopy, and electrochemistry. Their structures were confirmed by single-crystal X-ray diffraction analysis. Complexes 1 and 2 were crystalized in orthorhombic, Pbca, and monoclinic, P21/n systems, respectively. Various spectroscopic techniques were employed to investigate the interaction of both complexes with calf thymus DNA (CT-DNA). The experimental data were confirmed by molecular docking studies, employing two different DNA sequences. Both complexes, 1 and 2, bind with DNA via a minor groove mode of binding. MTT experiments revealed that both complexes induce apoptosis of MCF-7 (breast cancer) cells in low concentrations. Confocal microscopy indicated that 2 localizes in the nucleus and internalizes more efficiently in MCF-7 than in HEK-293." @default.
- W3161053473 created "2021-05-24" @default.
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- W3161053473 date "2021-05-12" @default.
- W3161053473 modified "2023-10-13" @default.
- W3161053473 title "Synthesis, DNA-Binding, Anticancer Evaluation, and Molecular Docking Studies of Bishomoleptic and Trisheteroleptic Ru-Diimine Complexes Bearing 2-(2-Pyridyl)-quinoxaline" @default.
- W3161053473 cites W129845126 @default.
- W3161053473 cites W1956384851 @default.
- W3161053473 cites W1967457845 @default.
- W3161053473 cites W1968274923 @default.
- W3161053473 cites W1970393749 @default.
- W3161053473 cites W1973489898 @default.
- W3161053473 cites W1975217371 @default.
- W3161053473 cites W1975361879 @default.
- W3161053473 cites W1975402304 @default.
- W3161053473 cites W1977935357 @default.
- W3161053473 cites W1979621373 @default.
- W3161053473 cites W1984101131 @default.
- W3161053473 cites W1993474337 @default.
- W3161053473 cites W1995691835 @default.
- W3161053473 cites W1999895724 @default.
- W3161053473 cites W2001402348 @default.
- W3161053473 cites W2006354060 @default.
- W3161053473 cites W2007428182 @default.
- W3161053473 cites W2012134325 @default.
- W3161053473 cites W2013882970 @default.
- W3161053473 cites W2019635982 @default.
- W3161053473 cites W2021381732 @default.
- W3161053473 cites W2027793825 @default.
- W3161053473 cites W2027793956 @default.
- W3161053473 cites W2032367891 @default.
- W3161053473 cites W2032706989 @default.
- W3161053473 cites W2033759861 @default.
- W3161053473 cites W2040184556 @default.
- W3161053473 cites W2042718393 @default.
- W3161053473 cites W2049037803 @default.
- W3161053473 cites W2057340637 @default.
- W3161053473 cites W2060335449 @default.
- W3161053473 cites W2063334178 @default.
- W3161053473 cites W2066931502 @default.
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- W3161053473 cites W2073844961 @default.
- W3161053473 cites W2080747382 @default.
- W3161053473 cites W2086945873 @default.
- W3161053473 cites W2091444495 @default.
- W3161053473 cites W2093949274 @default.
- W3161053473 cites W2095335747 @default.
- W3161053473 cites W2112840315 @default.
- W3161053473 cites W2113813397 @default.
- W3161053473 cites W2113924048 @default.
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- W3161053473 cites W2131350133 @default.
- W3161053473 cites W2138328175 @default.
- W3161053473 cites W2143034953 @default.
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- W3161053473 cites W2167337442 @default.
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- W3161053473 cites W2565364512 @default.
- W3161053473 cites W2577366206 @default.
- W3161053473 cites W2769018834 @default.
- W3161053473 cites W2771006473 @default.
- W3161053473 cites W2782371840 @default.
- W3161053473 cites W2895186407 @default.
- W3161053473 cites W2900898785 @default.
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- W3161053473 doi "https://doi.org/10.1155/2021/5599773" @default.
- W3161053473 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8137304" @default.
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- W3161053473 hasPublicationYear "2021" @default.
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