FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161110562> ?p ?o ?g. }

• W3161110562 abstract "Abstract Pharmacogenomic studies have revealed associations between rs1967309 in the adenylyl cyclase type 9 ( ADCY9 ) gene and clinical responses to the cholesteryl ester transfer protein (CETP) modulator dalcetrapib, however, the mechanism behind this interaction is still unknown. Here, we characterized selective signals at the locus associated with the pharmacogenomic response in human populations and we show that rs1967309 region exhibits signatures of positive selection in several human populations. Furthermore, we identified a variant in CETP , rs158477, which is in long-range linkage disequilibrium with rs1967309 in the Peruvian population. The signal is mainly seen in males, a sex-specific result that is replicated in the LIMAA cohort of over 3,400 Peruvians. Analyses of RNA-seq data further suggest an epistatic interaction on CETP expression levels between the two SNPs in multiple tissues, which also differs between males and females. We also detected interaction effects of the two SNPs with sex on cardiovascular phenotypes in the UK Biobank, in line with the sex-specific genotype associations found in Peruvians at these loci. We propose that ADCY9 and CETP coevolved during recent human evolution due to sex-specific selection, which points towards a biological link between dalcetrapib’s pharmacogene ADCY9 and its therapeutic target CETP ." @default.
• W3161110562 created "2021-05-24" @default.
• W3161110562 creator A5010560388 @default.
• W3161110562 creator A5015987572 @default.
• W3161110562 creator A5016585931 @default.
• W3161110562 creator A5018478383 @default.
• W3161110562 creator A5021219454 @default.
• W3161110562 creator A5021987832 @default.
• W3161110562 creator A5032154453 @default.
• W3161110562 creator A5036234416 @default.
• W3161110562 creator A5039186279 @default.
• W3161110562 creator A5046714332 @default.
• W3161110562 creator A5049309607 @default.
• W3161110562 creator A5054716145 @default.
• W3161110562 creator A5063545817 @default.
• W3161110562 creator A5083264116 @default.
• W3161110562 creator A5084151026 @default.
• W3161110562 creator A5087982590 @default.
• W3161110562 date "2021-05-14" @default.
• W3161110562 modified "2023-10-13" @default.
• W3161110562 title "A sex-specific evolutionary interaction between<i>ADCY9</i>and<i>CETP</i>" @default.
• W3161110562 cites W1590291211 @default.
• W3161110562 cites W1700829084 @default.
• W3161110562 cites W1865663516 @default.
• W3161110562 cites W1963217121 @default.
• W3161110562 cites W1964854676 @default.
• W3161110562 cites W1967314909 @default.
• W3161110562 cites W1968464155 @default.
• W3161110562 cites W1974323803 @default.
• W3161110562 cites W1975103250 @default.
• W3161110562 cites W1986911601 @default.
• W3161110562 cites W1995945762 @default.
• W3161110562 cites W2000380175 @default.
• W3161110562 cites W2010666779 @default.
• W3161110562 cites W2018838463 @default.
• W3161110562 cites W2025253353 @default.
• W3161110562 cites W2042040452 @default.
• W3161110562 cites W2059352588 @default.
• W3161110562 cites W2059596924 @default.
• W3161110562 cites W2060150493 @default.
• W3161110562 cites W2065267952 @default.
• W3161110562 cites W2068771737 @default.
• W3161110562 cites W2078074521 @default.
• W3161110562 cites W2082704080 @default.
• W3161110562 cites W2085381159 @default.
• W3161110562 cites W2089866557 @default.
• W3161110562 cites W2091239497 @default.
• W3161110562 cites W2093478783 @default.
• W3161110562 cites W2094248952 @default.
• W3161110562 cites W2099697702 @default.
• W3161110562 cites W2100751001 @default.
• W3161110562 cites W2104549677 @default.
• W3161110562 cites W2105381419 @default.
• W3161110562 cites W2108234281 @default.
• W3161110562 cites W2118825330 @default.
• W3161110562 cites W2120872997 @default.
• W3161110562 cites W2128371599 @default.
• W3161110562 cites W2129204179 @default.
• W3161110562 cites W2135964605 @default.
• W3161110562 cites W2146840080 @default.
• W3161110562 cites W2147575903 @default.
• W3161110562 cites W2149992227 @default.
• W3161110562 cites W2151227169 @default.
• W3161110562 cites W2162671544 @default.
• W3161110562 cites W2163722216 @default.
• W3161110562 cites W2167878272 @default.
• W3161110562 cites W2169421412 @default.
• W3161110562 cites W2170584954 @default.
• W3161110562 cites W2171932688 @default.
• W3161110562 cites W2260460598 @default.
• W3161110562 cites W2336766681 @default.
• W3161110562 cites W2345650612 @default.
• W3161110562 cites W2398204186 @default.
• W3161110562 cites W2462627069 @default.
• W3161110562 cites W2503247277 @default.
• W3161110562 cites W2530789499 @default.
• W3161110562 cites W2582676813 @default.
• W3161110562 cites W2590997912 @default.
• W3161110562 cites W2594266864 @default.
• W3161110562 cites W2603604229 @default.
• W3161110562 cites W2727705276 @default.
• W3161110562 cites W2741076111 @default.
• W3161110562 cites W2751069763 @default.
• W3161110562 cites W2761275051 @default.
• W3161110562 cites W2766876724 @default.
• W3161110562 cites W2800778443 @default.
• W3161110562 cites W2803018862 @default.
• W3161110562 cites W2809884208 @default.
• W3161110562 cites W2907665228 @default.
• W3161110562 cites W2914815304 @default.
• W3161110562 cites W2945612141 @default.
• W3161110562 cites W2952013316 @default.
• W3161110562 cites W2953133001 @default.
• W3161110562 cites W2964359086 @default.
• W3161110562 cites W2969386376 @default.
• W3161110562 cites W3024183622 @default.
• W3161110562 cites W3088178236 @default.
• W3161110562 cites W3108048195 @default.
• W3161110562 cites W3109016803 @default.
• W3161110562 cites W4231922091 @default.

• next