Matches in SemOpenAlex for { <https://semopenalex.org/work/W3161112014> ?p ?o ?g. }
- W3161112014 abstract "The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD." @default.
- W3161112014 created "2021-05-24" @default.
- W3161112014 creator A5005512506 @default.
- W3161112014 creator A5012816071 @default.
- W3161112014 creator A5013993151 @default.
- W3161112014 creator A5026984704 @default.
- W3161112014 creator A5040650036 @default.
- W3161112014 creator A5078204215 @default.
- W3161112014 creator A5085275892 @default.
- W3161112014 date "2021-05-21" @default.
- W3161112014 modified "2023-10-03" @default.
- W3161112014 title "Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality" @default.
- W3161112014 cites W1885362731 @default.
- W3161112014 cites W1977804070 @default.
- W3161112014 cites W1984323294 @default.
- W3161112014 cites W2018707355 @default.
- W3161112014 cites W2031441917 @default.
- W3161112014 cites W2048830729 @default.
- W3161112014 cites W2065359733 @default.
- W3161112014 cites W2082850379 @default.
- W3161112014 cites W2083279903 @default.
- W3161112014 cites W2088833470 @default.
- W3161112014 cites W2090466892 @default.
- W3161112014 cites W2100778793 @default.
- W3161112014 cites W2108718991 @default.
- W3161112014 cites W2117029190 @default.
- W3161112014 cites W2131271579 @default.
- W3161112014 cites W2134977136 @default.
- W3161112014 cites W2151487996 @default.
- W3161112014 cites W2164342861 @default.
- W3161112014 cites W2166171121 @default.
- W3161112014 cites W2337492846 @default.
- W3161112014 cites W2460515486 @default.
- W3161112014 cites W2539003831 @default.
- W3161112014 cites W2560780914 @default.
- W3161112014 cites W2586552311 @default.
- W3161112014 cites W2588064801 @default.
- W3161112014 cites W2730486832 @default.
- W3161112014 cites W2740167666 @default.
- W3161112014 cites W2772852580 @default.
- W3161112014 cites W2784772912 @default.
- W3161112014 cites W2788695973 @default.
- W3161112014 cites W2790416725 @default.
- W3161112014 cites W2791219314 @default.
- W3161112014 cites W2791904618 @default.
- W3161112014 cites W2797872931 @default.
- W3161112014 cites W2805352732 @default.
- W3161112014 cites W2806340304 @default.
- W3161112014 cites W2807669085 @default.
- W3161112014 cites W2884283422 @default.
- W3161112014 cites W2888072686 @default.
- W3161112014 cites W2901982449 @default.
- W3161112014 cites W2902315967 @default.
- W3161112014 cites W2904925223 @default.
- W3161112014 cites W2909701226 @default.
- W3161112014 cites W2910042249 @default.
- W3161112014 cites W2912729292 @default.
- W3161112014 cites W2944574897 @default.
- W3161112014 cites W2974804309 @default.
- W3161112014 cites W2979803667 @default.
- W3161112014 cites W2983288534 @default.
- W3161112014 cites W2994694872 @default.
- W3161112014 cites W2995725664 @default.
- W3161112014 cites W3001047124 @default.
- W3161112014 cites W3006731180 @default.
- W3161112014 cites W3012981415 @default.
- W3161112014 cites W3017687862 @default.
- W3161112014 cites W3025278547 @default.
- W3161112014 cites W3058117360 @default.
- W3161112014 cites W3088335827 @default.
- W3161112014 cites W4297901811 @default.
- W3161112014 doi "https://doi.org/10.3389/fpsyt.2021.645045" @default.
- W3161112014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8175648" @default.
- W3161112014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34093266" @default.
- W3161112014 hasPublicationYear "2021" @default.
- W3161112014 type Work @default.
- W3161112014 sameAs 3161112014 @default.
- W3161112014 citedByCount "30" @default.
- W3161112014 countsByYear W31611120142021 @default.
- W3161112014 countsByYear W31611120142022 @default.
- W3161112014 countsByYear W31611120142023 @default.
- W3161112014 crossrefType "journal-article" @default.
- W3161112014 hasAuthorship W3161112014A5005512506 @default.
- W3161112014 hasAuthorship W3161112014A5012816071 @default.
- W3161112014 hasAuthorship W3161112014A5013993151 @default.
- W3161112014 hasAuthorship W3161112014A5026984704 @default.
- W3161112014 hasAuthorship W3161112014A5040650036 @default.
- W3161112014 hasAuthorship W3161112014A5078204215 @default.
- W3161112014 hasAuthorship W3161112014A5085275892 @default.
- W3161112014 hasBestOaLocation W31611120141 @default.
- W3161112014 hasConcept C111919701 @default.
- W3161112014 hasConcept C113280763 @default.
- W3161112014 hasConcept C118552586 @default.
- W3161112014 hasConcept C126322002 @default.
- W3161112014 hasConcept C139719470 @default.
- W3161112014 hasConcept C143121216 @default.
- W3161112014 hasConcept C15744967 @default.
- W3161112014 hasConcept C162324750 @default.
- W3161112014 hasConcept C203014093 @default.
- W3161112014 hasConcept C2775841894 @default.